N,N-Bis-(3-amino-propyl)-succinamic acid | 199737-12-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N,N-Bis-(3-amino-propyl)-succinamic acid
• 英文别名: 4-[Bis(3-aminopropyl)amino]-4-oxobutanoic acid
• CAS: 199737-12-7
• 化学式: C₁₀H₂₁N₃O₃
• 分子量: 231.295
• InChiKey: ATMHUYIZNXJRJV-UHFFFAOYSA-N

物化性质

• 沸点：
  448.4±40.0 °C(Predicted)
• 密度：
  1.156±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.3
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  110
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  氯甲酸-9-芴基甲酯 、 N,N-Bis-(3-amino-propyl)-succinamic acid 在 sodium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 反应 12.0h， 以72%的产率得到N,N-bis-[3-(9H-fluoren-9-yl-methoxycarbonylamino)propyl]succinamic acid
  参考文献：
  名称：

  Multivalent neoglycoconjugates: solid-phase synthesis of N-linked α-sialodendrimers

  摘要：

  一系列具有2、4和8价键的N-连接α-唾液酸树枝状化合物，已通过王树脂和9-芴甲氧羰基及2-(1H-苯并三唑-1-基)-1,1,3,3-四甲基脲四氟硼酸盐固相化学方法，构建于N,N-双(3-氨丙基)琥珀酰亚胺酸核心骨架上。

  DOI：

  10.1039/a703679e
• 作为产物：
  描述：

  3,3'-二氨基二丙基胺 在 palladium on activated charcoal 氢气 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 5.0h， 生成 N,N-Bis-(3-amino-propyl)-succinamic acid
  参考文献：
  名称：

  Multivalent neoglycoconjugates: solid-phase synthesis of N-linked α-sialodendrimers

  摘要：

  一系列具有2、4和8价键的N-连接α-唾液酸树枝状化合物，已通过王树脂和9-芴甲氧羰基及2-(1H-苯并三唑-1-基)-1,1,3,3-四甲基脲四氟硼酸盐固相化学方法，构建于N,N-双(3-氨丙基)琥珀酰亚胺酸核心骨架上。

  DOI：

  10.1039/a703679e

文献信息

• PEPTIDE NUCLEIC ACIDS CONJUGATED WITH MULTI-AMINE LINKERS AND NUCLEIC ACID DETECTING DEVICE USING THE SAME
  申请人：Lee Hyunil

  公开号：US20090312197A1

  公开（公告）日：2009-12-17

  The present invention relates to a peptide nucleic acid (PNA) conjugated with multi-amine linkers, and a method to prepare the same and utilization thereof. More specifically, the method is characterized by conjugating monomers having multi-amine functionality sequentially at a PNA terminal, and effectively immobilizing the PNA conjugated with multi-amine linkers on a solid surface. A PNA array prepared using the PNA conjugated with multi-amine linkers exhibits improved sensitivity and specificity of signals for detecting target nucleic acids as compared to a PNA array using PNA probes having only one amine group. The PNA conjugated with multi-amine linkers can be utilized in nucleic acid detecting devices or kits for gene diagnosis such as PNA microarrays, PNA chips, PNA field-effect transistors and impedance detectors.

  本发明涉及一种与多胺连接物共轭的肽核酸（PNA），以及其制备方法和利用方法。更具体地说，该方法的特点是将具有多胺官能团的单体依次共轭到PNA末端，并有效地固定带有多胺连接物的PNA在固体表面上。使用带有多胺连接物的PNA制备的PNA阵列与仅具有一个胺基的PNA探针相比，显示出更高的信号灵敏度和特异性，可用于检测目标核酸。带有多胺连接物的PNA可用于核酸检测设备或基因诊断工具，例如PNA微阵列、PNA芯片、PNA场效应晶体管和阻抗检测器。
• TETRAMALEIMIDE LINKERS AND USE THEREOF
  申请人：NewBio Therapeutics, Inc.

  公开号：US20210128668A1

  公开（公告）日：2021-05-06

  The present invention is directed to tetramaleimide linkers and use thereof, more specifically to the compounds represented by formula I and their use in the preparation of antibody-drug conjugates (ADCs). The ADCs obtained from the tetramaleimide linkers have high homogeneity and stability, and could be used effectively for the treatment of various diseases including tumors. The definition of the groups in formula I is the same as that in the description.
• US8133985B2
  申请人：——

  公开号：US8133985B2

  公开（公告）日：2012-03-13
• [EN] TETRAMALEIMIDE LINKERS AND USE THEREOF<br/>[FR] LIEURS AU TÉTRAMALÉIMIDE ET UTILISATION DE CES DERNIERS
  申请人：NEWBIO THERAPEUTICS INC

  公开号：WO2019033773A1

  公开（公告）日：2019-02-21

  The present invention is directed to tetramaleimide linkers and use thereof, more specifically to the compounds represented by formula I and their use in the preparation of antibody-drug conjugates (ADCs). The ADCs obtained from the tetramaleimide linkers have high homogeneity and stability, and could be used effectively for the treatment of various diseases including tumors. The definition of the groups in formula I is the same as that in the description.