diisopropyl benzenesulfonyloxymethylphosphonate | 34833-69-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diisopropyl benzenesulfonyloxymethylphosphonate
• 英文别名: (Di-isopropoxyphosphinyl)-methyl-phenylsulfonat；benzenesulfonyloxymethyl-phosphonic acid diisopropyl ester；(diisopropoxyphosphoryl)methylbenzenesulfonate；Di(propan-2-yloxy)phosphorylmethyl benzenesulfonate
• CAS: 34833-69-7
• 化学式: C₁₃H₂₁O₆PS
• 分子量: 336.346
• InChiKey: ZXCPVDIEHPECIV-UHFFFAOYSA-N

物化性质

• 沸点：
  436.7±28.0 °C(Predicted)
• 密度：
  1.226±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  87.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  diisopropyl benzenesulfonyloxymethylphosphonate 在 sodium ethanolate 作用下， 生成
  参考文献：
  名称：

  Petrov,K.A. et al., Journal of general chemistry of the USSR, 1977, vol. 47, p. 2494 - 2501

  摘要：

  DOI：
• 作为产物：
  描述：

  (2E,4E)-5-(4-羟基-2,2,6-三甲基-7-氧杂二环[4.1.0]庚-1-基)-3-甲基戊-2,4-二烯醛 、 苯磺酰氯 在 三乙胺 作用下， 以 甲苯 为溶剂， 反应 2.0h， 生成 diisopropyl benzenesulfonyloxymethylphosphonate
  参考文献：
  名称：

  [EN] NUCLEOBASE PHOSPHONATE ANALOGS FOR ANTIVIRAL TREATMENT
  [FR] ANALOGUES DE PHOSPHONATE DE NUCLEOBASE POUR TRAITEMENT ANTIVIRAL

  摘要：

  公开号：

  WO2005012324A3

文献信息

• 신규한 설포닐옥시메틸포스포네이트 유도체 및 이를 이용한 다이아이소프로필 ((1-(트리틸옥시메틸)-사이클로프로필)옥시)메틸 포스포네이트의 제조방법
  申请人：LG CHEM, LTD. 주식회사 엘지화학(120010134563) Corp. No ▼ 110111-2207995BRN ▼107-81-98139

  公开号：KR101832238B1

  公开（公告）日：2018-02-26

  본 발명은 항바이러스제로 개발 중인 하기 화학식 1의 뉴클레오타이드 유사체를 합성하는데 있어서 중요한 중간체인 하기 화학식 2의 다이아이소프로필 ((1-(트리틸옥시메틸)-사이클로프로필)옥시)메틸포스포네이트 화합물을 합성하는 새로운 방법에 관한 것이다. 본 발명은 또한 화학식 2의 화합물을 제조하는데 중간체로서 유용하게 사용되는 화학식 3의 신규한 설포닐옥시메틸포스포네이트 화합물에 관한 것이다. [화학식 1] [화학식 2] [화학식 3] 상기 식에서 R’및 R은 명세서에 정의한 바와 같다.

  该专利涉及一种用于合成化学式2的二异丙基((1-(三甲氧基甲基)-环丙基)氧)甲基磷酸酯化合物的新方法，该化学式是合成化学式1的核苷酸类似物正在开发的重要中间体。该专利还涉及一种用作合成化学式2化合物的中间体的新型硫代磷酸甲酯化合物，其化学式为3。【化学式1】【化学式2】【化学式3】其中R'和R如规范所定义。
• Antiviral phosphonate analogs
  申请人：Boojamra G. Constantine

  公开号：US20050215513A1

  公开（公告）日：2005-09-29

  The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  该发明涉及具有抗病毒活性的磷取代化合物，含有这种化合物的组合物以及包括给予这种化合物的治疗方法，还涉及用于制备这种化合物的过程和中间体。
• Anti-cancer phosphonate analogs
  申请人：Boojamra G. Constantine

  公开号：US20060079478A1

  公开（公告）日：2006-04-13

  The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及磷取代的抗癌化合物，含有这些化合物的组合物以及包括给予这些化合物的治疗方法，以及用于制备这些化合物的过程和中间体。
• Nucleobase phosphonate analogs for antiviral treatment
  申请人：Krawczyk H. Steven

  公开号：US20050059637A1

  公开（公告）日：2005-03-17

  The present invention provides novel compounds with activity against infectious viruses. The compounds of the invention may inhibit retroviral reverse transcriptases and thus inhibit the replication of the virus. They are useful for treating human patients infected with a human retrovirus, such as human immunodeficiency virus (strains of HIV-1 or HIV-2) or human T-cell leukemia viruses (HTLV-I or HTLV-II) which results in acquired immunodeficiency syndrome (AIDS) and/or related diseases. The present invention also relates generally to the accumulation or retention of therapeutic compounds inside cells. The invention is more particularly related to attaining high concentrations of active metabolite molecules in HIV infected cells. Intracellular targeting may be achieved by methods and compositions which allow accumulation or retention of biologically active agents inside cells. Such effective targeting may be applicable to a variety of therapeutic formulations and procedures.

  本发明提供了一种对抗传染病毒的新化合物。本发明的化合物可以抑制逆转录病毒逆转录酶，从而抑制病毒的复制。它们可用于治疗感染人类逆转录病毒（如HIV-1或HIV-2的菌株）或人类T细胞白血病病毒（HTLV-I或HTLV-II）而导致获得性免疫缺陷综合症（AIDS）和/或相关疾病的人类患者。本发明还涉及治疗化合物在细胞内的积累或保留。本发明更具体地涉及在感染HIV的细胞中获得活性代谢物分子的高浓度。通过允许生物活性剂在细胞内积累或保留的方法和组合物可以实现细胞内靶向。这种有效的靶向可以适用于各种治疗配方和程序。
• Antiviral compounds
  申请人：Cai Zhenhong R.

  公开号：US20080076740A1

  公开（公告）日：2008-03-27

  The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  该发明涉及磷取代的抗病毒抑制化合物、含有该化合物的组合物、包括给予该化合物的治疗方法，以及用于制备该化合物的有用过程和中间体。