7,7'-dithiodiheptanoic acid | 14518-68-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 7,7'-dithiodiheptanoic acid
• 英文别名: 7,7'-disulfanediyldiheptanoic acid；Dithioheptansaeure；7-(6-Carboxyhexyldisulfanyl)heptanoic acid
• CAS: 14518-68-4
• 化学式: C₁₄H₂₆O₄S₂
• 分子量: 322.49
• InChiKey: VPELVJGZDYIHJP-UHFFFAOYSA-N

物化性质

• 沸点：
  505.8±35.0 °C(Predicted)
• 密度：
  1.164±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  125
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  7,7'-dithiodiheptanoic acid 在 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙腈 为溶剂， 反应 52.0h， 生成 (+)-N,N'-(7,7'-dithiodiheptanoyl)bis(O-phospho-L-threonine)
  参考文献：
  名称：

  10.1016/b978-0-12-385112-3.00009-3

  摘要：

  DOI：

  10.1016/b978-0-12-385112-3.00009-3
• 作为产物：
  描述：

  7-溴庚酸 在 碘 、 硫脲 、 potassium iodide 作用下， 以 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 19.0h， 生成 7,7'-dithiodiheptanoic acid
  参考文献：
  名称：

  10.1016/b978-0-12-385112-3.00009-3

  摘要：

  DOI：

  10.1016/b978-0-12-385112-3.00009-3

文献信息

• PEGylated Poly‐HDACi: A Designer Polyprodrug from Optimized Drug Units**
  作者：Jinghua Han、Da‐Yuan Wang、Qiuyu Wang、Li Meng、Zihan Luo、Jing Li、Yanke Kang、Wenhui Lv、Qingqing Huang、Peng George Wang、Yajie Wang、Jie Shen、Yanming Wang

  DOI：10.1002/chem.202103114

  日期：2022.1.19

  A designer tri-block copolymer is described to broaden epigenetic combination therapy. Upon intracellular reduction and esterase hydrolysis, it releases nothing but HDACi (histone deacetylase inhibitor) drug, CO2, and PEG. The design is rooted from a thiol-based HDACi, for which optimization balances requirements of both efficacy and control-release, highlighting a new paradigm in polyprodrug nanomedicine:

  一种设计的三嵌段共聚物被描述为拓宽表观遗传联合疗法。在细胞内还原和酯酶水解后，它只释放 HDACi（组蛋白脱乙酰酶抑制剂）药物、CO 2和 PEG。该设计源于基于硫醇的 HDACi，其优化平衡了功效和控制释放的要求，突出了多前体药物纳米药物的新范式：在药物化学阶段考虑药剂学指南。
• Chain Length Effect on the Structure and Photoelectrochemical Properties of Self-Assembled Monolayers of Porphyrins on Gold Electrodes
  作者：Hiroshi Imahori、Hiroyuki Norieda、Yoshinobu Nishimura、Iwao Yamazaki、Kazuo Higuchi、Naohiko Kato、Tomoyoshi Motohiro、Hiroko Yamada、Koichi Tamaki、Masatoshi Arimura、Yoshiteru Sakata

  DOI：10.1021/jp992768f

  日期：2000.2.1

  Disulfides, with a systematic series of alkyl spacers containing porphyrins at both terminals, were prepared to investigate the effect of the spacer length on the structure and photoelectrochemical properties of self-assembled monolayers (SAMs) of the porphyrins on a gold electrode. The structure of the SAMs was studied using ultraviolet (UV)-visible absorption spectroscopy in transmission mode, cyclic voltammetry, UV-visible ellipsometry, and fluorescence spectroscopy. These measurements showed that as the length of the spacers increases, the SAMs tend to form highly ordered structures on the gold electrodes. In addition, the structures of the monolayers vary depending on the even and odd number of the methylene spacers (n). From these measurements a porphyrin dimer model is proposed in that the two porphyrins take J-aggregate-like partially stacked structures in the monolayers. Photoelectrochemical studies were carried out in argon-saturated Na2SO4 aqueous solution containing methyl viologen as an electron carrier using the modified gold working electrode, a platinum wire counter electrode, and a Ag/AgCl reference electrode. The quantum yield increases in a zigzag fashion with an increase in the spacer length up to n = 6 and then starts decreasing slightly as the chain lengths become longer. A plausible explanation for the photocurrent trend comes from the following points: (i) there are two competitive deactivation pathways for the excited sing:let state of the porphyrin dimer, i.e., the quenching by the electrode via energy transfer and by the electron carrier via electron transfer, (ii) the porphyrin aggregation enhances the rate of nonradiative pathway in the excited state, and (iii) the electron transfer rate from the gold electrode to the resulting porphyrin cation radical decreases with an increase of the spacer lengths. These results will provide basic information for the construction of molecular assembly with photoactive function on surface.