tributyl(2,6-difluorophenyl)stannane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tributyl(2,6-difluorophenyl)stannane
• 英文别名: (2,6-difluorophenyl)tributyltin；2,6-Difluorophenyltributyltin；tributyl-(2,6-difluorophenyl)stannane
• 化学式: C₁₈H₃₀F₂Sn
• 分子量: 403.143
• InChiKey: DLTHSKKNYFFRAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.02
• 重原子数：
  21
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  tributyl(2,6-difluorophenyl)stannane 在 四(三苯基膦)钯 、 一水合肼 作用下， 以 甲醇 、 xylene 为溶剂， 反应 24.0h， 生成 5-(2,6-difluorophenyl)nicotinoyl hydrazide
  参考文献：
  名称：

  Biarylcarbamoylindolines Are Novel and Selective 5-HT_2C Receptor Inverse Agonists:  Identification of 5-Methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a Potential Antidepressant/Anxiolytic Agent

  摘要：

  The evolution, synthesis, and biological activity of a novel series of 5-HT2C receptor inverse agonists are reported. Biarylcarbamoylindolines have been identified with excellent 5-HT2C affinity and selectivity over 5-HT2A receptors. In addition, (pyridyloxypyridyl)carbamoylindolines have been discovered with additional selectivity over the closely related 5-HT2B receptor. Compounds from this series are inverse agonists at the human cloned 5-HT2C receptor, completely abolishing basal activity in a functional assay. The new series have reduced P450 inhibitory liability compared to a previously described series of 1-(3-pyridylcarbamoyl)indolines (Bromidge et al. J. Med. Chem. 1998, 41, 1598) from which they evolved. Compounds from this series showed excellent oral activity in a rat mCPP hypolocomotion model and in animal models of anxiety. On the basis of their favorable biological profile, 32 (SB-228357) and 40 (SB-243213) have been selected for further evaluation to determine their therapeutic potential for the treatment of CNS disorders such as depression and anxiety.

  DOI：

  10.1021/jm990388c
• 作为产物：
  描述：

  1,3-二氟苯 、 三丁基氯化锡 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 4.0h， 以88.6%的产率得到tributyl(2,6-difluorophenyl)stannane
  参考文献：
  名称：

  用于制备 2,6-双（二苯基膦）溴苯和相关双（氧化膦）的有机锡路线。新型配体的前体

  摘要：

  2,6-二氟苯基三烷基锡烷2,6-F 2 C 6 H 3 SnR 3 ( 1，R=Me；2，R=Bu)由商业产品制备。使用Ph 2 PLi，1和2进行亲核取代得到2,6-双(二苯基膦基)苯基三烷基锡烷2,6-(Ph 2 P) 2 C 6 H 3 SnR 3 ( 3 , R=Me; 4 , R=卜）。的反应3与Ñ正丁基锂和BRCH 2 CH 2Br得到2,6-双(二苯基膦基)溴苯(2,6-(Ph 2 P) 2 C 6 H 3 Br, 5 )，其氧化得到相关的双(氧化膦) 2,6-[Ph 2 P(O)] 2 C 6 H 3 Br ( 6 )。5与n- BuLi反应生成 2,6-双(二苯基膦基)苯基锂、2,6-(Ph 2 P) 2 C 6 H 3 Li ( 7 )。尝试制备相关的双（氧化膦）2,6-[Ph 2 P(O)] 2来自6 的C 6 H 3 Li ( 8 )在低温下以类似的方式受到分解的

  DOI：

  10.1002/zaac.202100210

文献信息

• Pyranodipyridine Compound
  申请人：Eisai R&D Management Co., Ltd.

  公开号：US20170137436A1

  公开（公告）日：2017-05-18

  Compounds represented by formulae (I) to (XXII) or pharmaceutically acceptable salts thereof:

  由化学式(I)到(XXII)表示的化合物或其药用可接受的盐：
• Copper-catalyzed arylstannylation of arynes in a sequence
  作者：Hideya Tanaka、Hitoshi Kuriki、Teruhiko Kubo、Itaru Osaka、Hiroto Yoshida

  DOI：10.1039/c9cc02738f

  日期：——

  Copper-catalyzed arylstannylation of arynes has been developed. This transformation enables variously substituted ortho-stannylbiaryls and teraryls to be constructed straightforwardly. An electron-deficient tin center is the key, and thus the single or dual insertion of arynes into arylstannanes is precisely controllable by simply changing the equivalence of aryne precursors.

  已经开发了铜催化的芳烃的芳基甲锡烷基化。该转化使得可以直接构建各种取代的邻-锡烷基二芳基和三芳基。缺电子的锡中心是关键，因此，只需简单地改变芳烃前体的当量，即可精确控制芳烃单芳基或双芳烃的插入。
• Catalytic C−H Bond Stannylation: A New Regioselective Pathway to C−Sn Bonds via C−H Bond Functionalization
  作者：Meghan E. Doster、Jillian A. Hatnean、Tamara Jeftic、Sunjay Modi、Samuel A. Johnson

  DOI：10.1021/ja105588v

  日期：2010.9.1

  ubiquitous Stille coupling reaction utilizes Sn-C bonds and is of great utility to organic chemists. Unlike the B-C bonds used in the Miyaura-Suzuki coupling reaction, which are readily obtained via direct borylation of C-H bonds, routes to organotin compounds via direct C-H bond functionalization are lacking. Here we report that the nickel-catalyzed reaction of fluorinated arenes and pyridines with vinyl

  无处不在的 Stille 偶联反应利用 Sn-C 键，对有机化学家非常有用。与 Miyaura-Suzuki 偶联反应中使用的 BC 键不同，BC 键很容易通过 CH 键的直接硼酸化获得，但缺乏通过直接 CH 键官能化获得有机锡化合物的途径。在这里，我们报告氟化芳烃和吡啶与乙烯基锡烷的镍催化反应没有通过 CF 活化提供预期的乙烯基化合物，而是通过 CH 官能化提供新的 Sn-C 键，同时失去乙烯。这种机制为将 CH 键直接转化为碳-杂原子键提供了一种新的出乎意料的方法。
• An Organotin Route for the Preparation of 2,6‐Bis(diphenylphosphino)bromo‐benzene and the Related Bis(Phosphine Oxide). Precursors for Novel Ligands
  作者：Fabio Meyer、Thomas Kuzmera、Enno Lork、Matthias Vogt、Jens Beckmann

  DOI：10.1002/zaac.202100210

  日期：2021.10.12

  R=Bu) were prepared from commercial products. With Ph2PLi, 1 and 2 underwent nucleophilic substitution to give the 2,6-bis(diphenylphosphino)phenyltrialkylstannanes 2,6-(Ph2P)2C6H3SnR3 (3, R=Me; 4, R=Bu). The reaction of 3 with n-BuLi and BrCH2CH2Br afforded 2,6-bis(diphenylphosphino)bromobenzene (2,6-(Ph2P)2C6H3Br, 5), the oxidation of which gave the related bis(phosphine oxide) 2,6-[Ph2P(O)]2C6H3Br

  2,6-二氟苯基三烷基锡烷2,6-F 2 C 6 H 3 SnR 3 ( 1，R=Me；2，R=Bu)由商业产品制备。使用Ph 2 PLi，1和2进行亲核取代得到2,6-双(二苯基膦基)苯基三烷基锡烷2,6-(Ph 2 P) 2 C 6 H 3 SnR 3 ( 3 , R=Me; 4 , R=卜）。的反应3与Ñ正丁基锂和BRCH 2 CH 2Br得到2,6-双(二苯基膦基)溴苯(2,6-(Ph 2 P) 2 C 6 H 3 Br, 5 )，其氧化得到相关的双(氧化膦) 2,6-[Ph 2 P(O)] 2 C 6 H 3 Br ( 6 )。5与n- BuLi反应生成 2,6-双(二苯基膦基)苯基锂、2,6-(Ph 2 P) 2 C 6 H 3 Li ( 7 )。尝试制备相关的双（氧化膦）2,6-[Ph 2 P(O)] 2来自6 的C 6 H 3 Li ( 8 )在低温下以类似的方式受到分解的
• Tetracyclic compound
  申请人：Kyowa Hakko Kogyo Co., Ltd.

  公开号：US05646283A1

  公开（公告）日：1997-07-08

  This invention relates to a novel tetracyclic compound represented by formula (I): ##STR1## or its pharmacologically-acceptable salt. The compound of this invention has strong immunosuppressive activity, and is useful as an immunosuppressive agent and as an agent for treating autoimmune disease.

  本发明涉及一种新型四环化合物，其化学式为(I): ##STR1## 或其药学上可接受的盐。该化合物具有强烈的免疫抑制活性，可作为免疫抑制剂和治疗自身免疫性疾病的药物。