3-溴-2,6-二甲氧基-4-甲基-苯甲酸 | 54130-76-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-溴-2,6-二甲氧基-4-甲基-苯甲酸
• 英文名称: 3-bromo-2,6-dimethoxy-4-methyl-benzoic acid
• 英文别名: 3-Brom-2,6-dimethoxy-4-methyl-benzoesaeure；3-Brom-2.6-dimethoxy-4-methylbenzoesaeure；3-Bromo-2,6-dimethoxy-4-methylbenzoic acid
• CAS: 54130-76-6
• 化学式: C₁₀H₁₁BrO₄
• 分子量: 275.099
• InChiKey: XDDHSIPYCORWMW-UHFFFAOYSA-N

物化性质

• 沸点：
  388.2±42.0 °C(Predicted)
• 密度：
  1.507±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-溴-2,6-二甲氧基-4-甲基-苯甲酸 在 alkaline aqueous potassium permanganate solution 作用下， 生成 2-Brom-3,5-dimethoxy-benzoesaeure
  参考文献：
  名称：

  62.蓖麻酚，对-熊果酸和间苯三酚羧酸的甲基醚的卤素衍生物

  摘要：

  DOI：

  10.1039/jr9390000280
• 作为产物：
  描述：

  2,6-dimethoxy-4-methyl-benzoic acid methyl ester 在 氢氧化钾 、 溴 、 溶剂黄146 作用下， 生成 3-溴-2,6-二甲氧基-4-甲基-苯甲酸
  参考文献：
  名称：

  Median nerve evoked responses and explicit memory during recovery from isoflurane/nitrous oxide anesthesia

  摘要：

  Purpose: To evaluate median nerve somatosensory evoked responses during recovery from anesthesia in relation to clinical findings.Methods: Twenty-two gynecologic patients received isoflurane in nitrous oxide for anesthesia. Midlatency somatosensory evoked responses (N20, P25, N35, P45, N50) were recorded the day before surgery (AWAKE), during steady state anesthesia (STABLE), and every five minutes after discontinuation of anesthesia until the patients were able to name a shown object correctly (RECOVERY). Next day the patients were questioned with a structured interview about their explicit memory of the immediate recovery period and classified into groups: No-MEM (no memory) and MEM (memory). Multivariate analysis of variance compared electrophysiological parameters at the different time points and between the two memory groups.Results: During STABLE isoflurane/N2O anesthesia, all cortical amplitudes were reduced (P less than or equal to 0.003) and all latencies were prolonged compared with AWAKE (P < 0.001). At RECOVERY the latencies N35, P45, N50 remained prolonged (P less than or equal to 0.001), while the amplitudes N20P25 and P45N50 were reduced in comparison to AWAKE (P less than or equal to 0.02). The latencies P45 (48 +/- 8 vs 61 +/- 9 msec) and N50 (67 +/- 12 vs 81 +/- 10 msec) were shorter in the patients of the group MEM (P less than or equal to 0.03) at RECOVERY.Conclusion: The reversibility of anesthetic induced changes in amplitudes and latencies of median nerve somatosensory evoked responses reflected clinical awakening during emergence from isoflurane/nitrous oxide anesthesia. In the patients who had recall for the immediate recovery period, the reversibility of anesthetic induced changes of components P45 and N50 was faster than in patients without recall.

  DOI：

  10.1007/bf03018938

文献信息

• Asahina; Fuzikawa, Chemische Berichte, 1934, vol. 67, p. 163,166, 715
  作者：Asahina、Fuzikawa

  DOI：——

  日期：——