1,3-di-t-butyl-5-(methoxymethyl)benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-di-t-butyl-5-(methoxymethyl)benzene
• 英文别名: 1,3-Ditert-butyl-5-(methoxymethyl)benzene
• 化学式: C₁₆H₂₆O
• 分子量: 234.382
• InChiKey: SBTNEYZJNSNVNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-bromo-1-(bromomethyl)-3,5-di-t-butylbenzene 在 甲醇 、 正丁基锂 、 sodium methylate 、 三乙胺 、 三氯化磷 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 28.08h， 生成 1,3-di-t-butyl-5-(methoxymethyl)benzene
  参考文献：
  名称：

  Utilization of 2,4-Di-t-butyl-6-(methoxymethyl)phenyl as a New Sterically Protecting Group

  摘要：

  制备了一种立体受阻的溴苯，即 2-溴-1,5-二叔丁基-3-(甲氧基甲基)苯，并将其转化为相应的二氯化磷。然后利用这种二氯化物来稳定低配位磷化合物，如 1-[2,4-二叔丁基-6-（甲氧基甲基）苯基]-2-（2,4,6-三叔丁基苯基）二磷烷。此外，该二氯化物在室温下静置时会生成环化产物 1-氯-2,1-氧磷茚，并消除氯甲烷。

  DOI：

  10.1246/bcsj.66.3440

文献信息

• 5-5-Membered fused heterocyclic compound and use thereof as HCV polymerase inhibitor
  申请人：Mizojiri Ryo

  公开号：US20090036444A1

  公开（公告）日：2009-02-05

  The present invention relates to a fused ring compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt thereof, and a hepatitis C virus (HCV) polymerase inhibitor and a therapeutic agent for hepatitis C containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.

  本发明涉及一种由以下式[I]表示的融合环化合物，其中每个符号如规范中所定义，或其药学上可接受的盐，以及一种丙型肝炎病毒（HCV）聚合酶抑制剂和治疗丙型肝炎的药物，本发明的化合物基于HCV聚合酶抑制活性具有抗HCV活性，是一种预防或治疗丙型肝炎的药剂。
• Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
  申请人：Oka Takahiro

  公开号：US20070049593A1

  公开（公告）日：2007-03-01

  The present invention relates to a tetracyclic fused heterocyclic compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt thereof, and a hepatitis C virus (HCV) polymerase inhibitor and a therapeutic agent for hepatitis C containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.

  本发明涉及一种四环融合杂环化合物，其化学式为[I]，其中每个符号的定义如规范中所述，或其药学上可接受的盐，以及一种丙型肝炎病毒（HCV）聚合酶抑制剂和治疗丙型肝炎的药物，本发明的化合物表现出基于HCV聚合酶抑制活性的抗HCV活性，因此可用作预防或治疗丙型肝炎的药物。
• TETRACYCLIC FUSED HETEROCYCLIC COMPOUND AND USE THEREOF AS HCV POLYMERASE INHIBITOR
  申请人：Oka Takahiro

  公开号：US20120070409A1

  公开（公告）日：2012-03-22

  The present invention relates to a tetracyclic fused heterocyclic compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt thereof, and a hepatitis C virus (HCV) polymerase inhibitor and a therapeutic agent for hepatitis C containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.

  本发明涉及一种四环融合杂环化合物，其表示为以下公式[I]，其中每个符号如规范中所定义，或其药学上可接受的盐，以及一种丙型肝炎病毒（HCV）聚合酶抑制剂和治疗丙型肝炎的药物，本发明的化合物基于HCV聚合酶抑制活性显示出抗HCV活性，可用作预防或治疗丙型肝炎的药物。
• 5-5-MEMBERED FUSED HETEROCYCLIC COMPOUND AND USE THEREOF AS HCV POLYMERASE INHIBITOR
  申请人：Mizojiri Ryo

  公开号：US20120020920A1

  公开（公告）日：2012-01-26

  The present invention relates to a fused ring compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt thereof, and a hepatitis C virus (HCV) polymerase inhibitor and a therapeutic agent for hepatitis C containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.

  本发明涉及一种由以下式[I]所表示的融合环化合物，其中每个符号如规范中所定义，或其药学上可接受的盐，以及一种丙型肝炎病毒（HCV）聚合酶抑制剂和治疗丙型肝炎的药物，本发明化合物基于HCV聚合酶抑制活性具有抗HCV活性，可用作预防或治疗丙型肝炎的药剂。
• Dyeable polyolefin fibers and rabrics
  申请人：——

  公开号：US20020161123A1

  公开（公告）日：2002-10-31

  Polyolefin fibers, filaments and fabrics made therefrom which comprise a melt blend which comprises (A) a polyolefin; and (B) at least one polyetheresteramide which contains aromatic diol-derived sections, exhibit excellent durable dyeability. The fabrics are useful in woven garments, carpeting, furniture and automobile upholstery, woven industrial fabrics, non-woven absorbents used in disposable diapers, non-woven garments including disposable medical garments, filter media, synthetic paper and the like.

  聚烯烃纤维、长丝和织物由熔融混合物制成，熔融混合物包括 (A) 聚烯烃；和 (B) 至少一种含有芳香族二元醇衍生部分的聚醚酯酰胺，具有优异的耐久染色性。这些织物可用于机织服装、地毯、家具和汽车内饰、机织工业织物、一次性尿布中使用的非织造吸收剂、包括一次性医疗服装在内的非织造服装、过滤介质、合成纸等。