N,N-diethyl-2-(2-hydroxyphenoxy)acetamide | 34919-94-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N,N-diethyl-2-(2-hydroxyphenoxy)acetamide
• CAS: 34919-94-3
• 化学式: C₁₂H₁₇NO₃
• mdl: MFCD11176850
• 分子量: 223.272
• InChiKey: OZKGMFCJODLMCA-UHFFFAOYSA-N

物化性质

• 沸点：
  375.1±22.0 °C(Predicted)
• 密度：
  1.123±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N,N-diethyl-2-(2-hydroxyphenoxy)acetamide 、 异丙胺 、 环氧氯丙烷 生成 N,N-Diethyl-2-[2-(2-hydroxy-3-isopropylamino-propoxy)-phenoxy]-acetamide
  参考文献：
  名称：

  DE2126169

  摘要：

  公开号：
• 作为产物：
  描述：

  1,4-苯并二氧六环-2-甲酸乙酯 在 sodium hydroxide 、 N-溴代丁二酰亚胺(NBS) 、 氯化亚砜 、 过氧化氢苯甲酰 作用下， 以 四氯化碳 、 甲苯 为溶剂， 反应 360.5h， 生成 N,N-diethyl-2-(2-hydroxyphenoxy)acetamide
  参考文献：
  名称：

  Effect of methoxy substitution on the adrenergic activity of three structurally related .alpha.2-adrenoreceptor antagonists

  摘要：

  We have recently reported the synthesis and alpha 2-antagonist activity of the methoxy derivative 2 [2-(2-methoxy-1,4-benzodioxan-2-yl)-2-imidazoline] and described the enhanced potency of this compound over the parent 1,4-benzodioxan, idazoxan, in reversing the inhibition caused by alpha 2-adrenoreceptor agonists of the electrically induced twitch in the rat or mouse vas deferens. It was of interest to us to discover whether a similar substitution in the structurally related alpha 2-adrenoreceptor antagonists piperoxan, prosympal, and fenmetazole would similarly enhance potency. We subsequently discovered that this was not so and potency was decreased markedly. In particular, that of the methoxy derivative of piperoxan was ca. 220 times less than the parent structure.

  DOI：

  10.1021/jm00159a037

文献信息

• STILLINGS M. R.; ENGLAND C. D.; WELBOURN A. P.; SMITH C. F. C., J. MED. CHEM., 29,(1986) N 9, 1780-1783
  作者：STILLINGS M. R.、 ENGLAND C. D.、 WELBOURN A. P.、 SMITH C. F. C.

  DOI：——

  日期：——
• DE2126169
  申请人：——

  公开号：——

  公开（公告）日：——
• Effect of methoxy substitution on the adrenergic activity of three structurally related .alpha.2-adrenoreceptor antagonists
  作者：Michael R. Stillings、C. David England、Anthony P. Welbourn、Colin F. C. Smith

  DOI：10.1021/jm00159a037

  日期：1986.9

  We have recently reported the synthesis and alpha 2-antagonist activity of the methoxy derivative 2 [2-(2-methoxy-1,4-benzodioxan-2-yl)-2-imidazoline] and described the enhanced potency of this compound over the parent 1,4-benzodioxan, idazoxan, in reversing the inhibition caused by alpha 2-adrenoreceptor agonists of the electrically induced twitch in the rat or mouse vas deferens. It was of interest to us to discover whether a similar substitution in the structurally related alpha 2-adrenoreceptor antagonists piperoxan, prosympal, and fenmetazole would similarly enhance potency. We subsequently discovered that this was not so and potency was decreased markedly. In particular, that of the methoxy derivative of piperoxan was ca. 220 times less than the parent structure.