Material Safety Data Sheet Section 1. Identification of the substance Product Name: N-tert-Butyl-2-nitroaniline Synonyms: Section 2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section 3. Composition/information on ingredients. Ingredient name: N-tert-Butyl-2-nitroaniline CAS number: 28458-45-9 Section 4. First aid measures Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section 5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section 6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution: Wear approved mask/respirator Hand precaution: Wear suitable gloves/gauntlets Skin protection: Wear suitable protective clothing Eye protection: Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section 7. Handling and storage Handling: This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels. Storage: Section 8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section 9. Physical and chemical properties Appearance: Not specified Boiling point: No data No data Melting point: Flash point: No data Density: No data Molecular formula: C10H14N2O2 Molecular weight: 194.2 Section 10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides. Section 11. Toxicological information No data. Section 12. Ecological information No data. Section 13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section 14. Transportation information Non-harzardous for air and ground transportation. Section 15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313.
通过相应硝基化合物的脱氧作用或相关叠氮化物的热解或光解反应制得的2-(2-硝基苯基)苯并噻唑通过攻击苯并噻唑氮而得到吲唑并[3,2- b ]苯并噻唑。在(2-(2-硝基苯基)苯并咪唑中,类似的氮原子侵蚀使得苯并咪唑并吲唑具有良好的收率。但是,在苯并咪唑中有适当的1-取代基(例如Me或CHMe 2)时,三重态(通过苯乙酮敏化的光解作用或带有4-二甲氨基的叠氮化物的热分解产生)的腈优先攻击该取代基得到苯并咪唑并喹唑啉。
[EN] CRBN LIGANDS AND USES THEREOF<br/>[FR] LIGANDS CRBN ET LEURS UTILISATIONS
申请人:KYMERA THERAPEUTICS INC
公开号:WO2019140387A1
公开(公告)日:2019-07-18
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
本发明提供了化合物、其组合物以及使用这些化合物抑制CRBN并治疗CRBN介导的疾病的方法。
GSK-3BETA INHIBITOR
申请人:Kori Masakuni
公开号:US20110039893A1
公开(公告)日:2011-02-17
For the purpose of providing a GSK-3β inhibitor containing a 2-aminopyridine compound or a salt thereof or a prodrug thereof useful as an agent for the prophylaxis or treatment of a GSK-3β-related pathology or disease, the present invention provides a GSK-3β inhibitor containing a compound represented by the formula (IA):
wherein each symbol is as defined in the specification.
or a salt thereof or a prodrug thereof.
serotonin and serotonin3 (5-HT3) antagonists using a two-dimensional grid template composed of regular hexagons, we deduced structural modification patterns from agonists to antagonists, and designed new 5-HT3 antagonist prototypes. Among them, 2-(4-methyl-1-piperazinyl)-1-butylbenzimidazole (6) was identified as a lead compound which has potent 5-HT3 antagonistic activity comparable to that of granisetron
Syntheses and<sup>15</sup>N NMR Spectra of Iminodiaziridines - Ring-Expansions of 1-Aryl-3-iminodiaziridines to 1<i>H</i>- and 3a<i>H</i>-Benzimidazoles, 2<i>H</i>-Indazoles, and 5<i>H</i>-Dibenzo[<i>d</i>,<i>f</i>][1,3]diazepines
3-dihydro-3aH-benzimidazoles. Otherwise, 2-amino-1H-benzimidazoles and strongly fluorescent 3-amino-2H-indazoles, originating from rearrangements of the elusive 1-aryl-3-iminodiaziridines, predominate. N′,N″-Diaryl-N-hydroxyguanidine O-sulfonic acids give only rearranged products: a 2-amino-1H-benzimidazole and a 6-amino-5H-dibenzo[d,f][1.3]diazepine if aryl = phenyl, or a 2-imino-2,3-dihydro-3aH-benzimidazole
Imidoyl dichlorides as new reagents for the rapid formation of 2-aminobenzimidazoles and related azoles
作者:Julie A. Pollock、Sung Hoon Kim、John A. Katzenellenbogen
DOI:10.1016/j.tetlet.2015.09.076
日期:2015.10
yields. The ability to incorporate various protecting groups makes the imidoyl dichloride reagent amenable to a large number of syntheses. The reagent is applied to the total synthesis of the 2-aminobenzimidazole containing carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), from 2-chloro-3-nitropyridine in >60% yield in 6 steps.
提出了在室温下有效合成五元和六元唑的试剂的开发。合成了多种取代的2-氨基苯并咪唑,收率良好至优异。掺入各种保护基的能力使亚氨酰二氯化物试剂适合于大量合成。该试剂可用于由> 60的2-氯-3-硝基吡啶全合成含2-氨基苯并咪唑的致癌物2-氨基-1-甲基-6-苯基咪唑并[4,5- b ]吡啶(PhIP) 6个步骤中的%收率。