2-氨基-3-乙氧基吡嗪 | 89464-86-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 2-氨基-3-乙氧基吡嗪
• 英文名称: 2-amino-3-ethoxypyrazine
• 英文别名: 3-ethoxypyrazin-2-amine
• CAS: 89464-86-8
• 化学式: C₆H₉N₃O
• 分子量: 139.157
• InChiKey: ZULCYKWRRGZJJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  61
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2933990090
• 危险性防范说明：
  P261,P280,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H332,H335

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 2-Amino-3-ethoxypyrazine
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 2-Amino-3-ethoxypyrazine
CAS number: 89464-86-8

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C6H9N3O
Molecular weight: 139.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-氨基-3-乙氧基吡嗪 以 1,4-二氧六环 、 乙醇 、 溶剂黄146 为溶剂， 反应 17.0h， 生成 3-Dimethylaminomethyl-8-ethoxy-2-phenylimidazo[1,2-a]pyrazine
  参考文献：
  名称：

  Research on heterocyclic compounds, XXXV. Synthesis of 2-phenylimidazo[1,2-a]pyrazine-3-acetates

  摘要：

  Prompted by the remarkable pharmacological activity shown by the corresponding carboxylic acids and other analogues, a series of 2-phenylimidazo[1,2-a]pyrazine-3-acetic acids has been prepared. A multi-step method similar to a synthetic procedure used to obtain Zolpidem, an imidazo[1,2-a]pyridine with hypnotic properties has been developed.

  DOI：

  10.1007/bf00807034

文献信息

• Concise synthesis of rare pyrido[1,2-a]pyrimidin-2-ones and related nitrogen-rich bicyclic scaffolds with a ring-junction nitrogen
  作者：T. A. Alanine、W. R. J. D. Galloway、S. Bartlett、J. J. Ciardiello、T. M. McGuire、D. R. Spring

  DOI：10.1039/c5ob01784j

  日期：——

  screening libraries and the physical and biological properties of the pyrido[1,2-a]pyrimidin-2-one scaffold have been poorly explored (indeed, the same can be said for unsaturated bicyclic compounds with a bridgehead nitrogen in general). Herein, we report the development of a new strategy for the concise synthesis of substituted pyrido[1,2-a]pyrimidin-2-ones from readily available starting materials.

  吡啶并[1,2 - a ]嘧啶-2-酮代表药学上有趣的一类杂环。与结构相关的吡啶并[1,2 - a ]嘧啶-4-酮具有广泛的有用的生物学特性。此外，这类带有桥头氮的喹喔嗪酮型支架有望表现出有趣的理化性质。然而，吡啶并[1,2一]嘧啶-2-酮在很大程度上是充分代表在当前的小分子筛选文库和吡啶并的物理和生物特性[1,2一] pyrimidin-2-one支架的研究很少（事实上，对于具有桥头氮的不饱和双环化合物也可以说是相同的）。在这里，我们报告了一种新的策略的发展，该策略是从容易获得的起始原料中精确合成取代的吡啶并[1,2 - a ]嘧啶-2-酮的方法。合成途径涉及2-氨基吡啶的锂酰胺基与炔酸酯的酰化反应以形成炔酰胺，然后在热条件下将其环化。使用氨基化锂阴离子确保优良的区位选择性为2-氧代异构体在所述不希望的4-氧代-异构体，它提供了超过对吡啶并合成一些现有的方法具有明显的优势[1,2一] p
• Dipyridyl amines: Potent metabotropic glutamate subtype 5 receptor antagonists
  作者：Theodore M. Kamenecka、Céline Bonnefous、Steven Govek、Jean-Michel Vernier、John Hutchinson、Janice Chung、Grace Reyes-Manalo、Jeffery J. Anderson

  DOI：10.1016/j.bmcl.2005.06.059

  日期：2005.10

  Modulation of the metabotropic glutamate subtype 5 (mGlu5) receptor may be useful in the treatment of a variety of central nervous system disorders. Herein, we report on the discovery, synthesis, and biological evaluation of dipyridyl amines as small molecule mGlu5 antagonists.

  代谢型谷氨酸亚型5（mGlu5）受体的调节可用于治疗多种中枢神经系统疾病。在本文中，我们报告了作为小分子mGlu5拮抗剂的二吡啶胺的发现，合成和生物学评估。
• Abignente; Arena; De Caprariis, European Journal of Medicinal Chemistry, 1985, vol. 20, # 1, p. 79 - 85
  作者：Abignente、Arena、De Caprariis、et al.

  DOI：——

  日期：——
• Research on heterocyclic compounds. XXXI. Synthesis and antiinflammatory activity of 2-arylimidazo[1,2-a]pyrazine-3-carboxylic acids
  作者：E Abignente、P de Caprariis、MG Rimoli、L Avallone、L Gomez Paloma、F Rossi、M D'Amico、V Calderaro、C Parrillo

  DOI：10.1016/0223-5234(93)90150-d

  日期：1993.1

  The synthesis of a series of 2-phenyl- and 2-(p-chlorophenyl)imidazo[1,2-a]pyrazine-3-carboxylic esters and acids is described. The structures of the new compounds were supported by H-1- and C-13-NMR spectra. These compounds were evaluated in vivo for their antiinflammatory and analgesic activities as well as for their ulcerogenic potential. Acids 8c and 8e were found to be the most potent antiinflammatory agents (almost-equal-to 1/8 x indomethacin), while 8a, 8d and 8f displayed analgesic activity (almost-equal-to 1/16 x indomethacin). The inhibitory activity on cyclooxygenase action was evaluated in vitro and discussed in comparison with results obtained in vivo.
• ABIGNENTE, E.;ARENA, F.;CAPRARIIS, P. DE;PATSCOT, R.;MARMO, E.;LAMPA, E.;+, EUR. J. MED. CHEM.-CHEM. THER., 1985, 20, N 1, 79-85
  作者：ABIGNENTE, E.、ARENA, F.、CAPRARIIS, P. DE、PATSCOT, R.、MARMO, E.、LAMPA, E.、+

  DOI：——

  日期：——