| 1334143-31-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 1334143-31-5
• 化学式: C₁₀H₁₄O₃
• 分子量: 182.219
• InChiKey: JFYJAGUOFZFQCM-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.49
• 重原子数：
  13.0
• 可旋转键数：
  5.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  35.53
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  在 二异丁基氢化铝 、 三甲基膦 作用下， 以 四氢呋喃 、 乙醚 、 正己烷 、 二氯甲烷 为溶剂， 反应 4.0h， 生成
  参考文献：
  名称：

  Marrying Iterative Synthesis to Cascading Radical Cyclization: 6-endo/5-exo Radical Cascade across Bis-Vinyl Ethers

  摘要：

  Application of iterative protocols to the synthesis of functionally and stereochemically complex small molecules is an emerging area of research with the potential to create new efficiencies in complex molecule synthesis. Similarly, the discovery of tandem or cascade reactions can aid In the rapid generation of new structures for biological screening programs. This report describes a cascading 6-endo-trig/5-exo-trig radical cyclization across bis-vinyl ether substrates, which are themselves iteratively synthesized from simple building blocks.

  DOI：

  10.1021/ol202286q
• 作为产物：
  描述：

  2-丁炔酸乙酯 、 3-丁炔-1-醇 在 三甲基膦 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 以100%的产率得到
  参考文献：
  名称：

  Marrying Iterative Synthesis to Cascading Radical Cyclization: 6-endo/5-exo Radical Cascade across Bis-Vinyl Ethers

  摘要：

  Application of iterative protocols to the synthesis of functionally and stereochemically complex small molecules is an emerging area of research with the potential to create new efficiencies in complex molecule synthesis. Similarly, the discovery of tandem or cascade reactions can aid In the rapid generation of new structures for biological screening programs. This report describes a cascading 6-endo-trig/5-exo-trig radical cyclization across bis-vinyl ether substrates, which are themselves iteratively synthesized from simple building blocks.

  DOI：

  10.1021/ol202286q