cis-dimethyl tetrahydrothiophene-3,4-dicarboxylate | 105850-95-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cis-dimethyl tetrahydrothiophene-3,4-dicarboxylate
• 英文别名: cis-tetrahydro-thiophene-3,4-dicarboxylic acid dimethyl ester；cis-Tetrahydro-thiophen-3,4-dicarbonsaeure-dimethylester；rel-3,4-Dimethyl (3S,4R)-tetrahydro-3,4-thiophenedicarboxylate；dimethyl (3R,4S)-thiolane-3,4-dicarboxylate
• CAS: 105850-95-1
• 化学式: C₈H₁₂O₄S
• 分子量: 204.247
• InChiKey: DHKCGAJEQXUMME-OLQVQODUSA-N

物化性质

• 沸点：
  293.8±40.0 °C(Predicted)
• 密度：
  1.249±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  77.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  cis-dimethyl tetrahydrothiophene-3,4-dicarboxylate 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 cis-3,4-bis(hydroxymethyl)thiacyclopentane
  参考文献：
  名称：

  Synthesis of 4′-thionucleosides by 1,3-dipolar cycloadditions of the simplest thiocarbonyl ylide with alkenes bearing electron-withdrawing groups

  摘要：

  Reactions of the simplest thiocarbonyl ylide with a variety of appropriate alkenes bearing electron-withdrawing substituents afforded the corresponding tetrahydrothiophenes, which could be easily elaborated into hydroxy and hydroxymethyl derivatives and then coupled with nucleobases to produce different 4 '-thionucleo sides. Particularly, alpha- and beta-anomers of 1-[3,4-bis(hydroxymethyl)tetrahydro-2-thienyl]-thymine, -cytosine, -uracil and -fluorouracil were prepared with dimethyl fumarate and maleate, while 1-[4-(hydroxymethyl)tetrahydro-2-thienyl]- and 1-[4-(hydroxymethyl)tetrahydro-3-thienyl]-thymine, -cytosine, -uracil and -fluorouracil were prepared with a chiral alpha,beta-unsaturated amide. These processes, simple in the experimental conditions and large availability of the starting materials, affording moderate to good yields of 4 '-thionucleosides, represent an optimum alternative to those, already known, based on sugars, which often have the drawbacks of a higher number of steps and lower yields. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.05.080
• 作为产物：
  描述：

  马来酸二甲酯 、 chloromethyl (trimethylsilyl)methyl sulfide 在 cesium fluoride 作用下， 以 乙腈 为溶剂， 以84%的产率得到cis-dimethyl tetrahydrothiophene-3,4-dicarboxylate
  参考文献：
  名称：

  氯甲基三甲基甲硅烷基甲基硫醚作为母体硫代羰基内酯合成子。二氢和四氢噻吩的简单合成

  摘要：

  氯甲基三甲基甲硅烷基甲基硫化物充当母体硫代羰基内酯的合成子，并在室温下在乙腈中与氟化铯催化的活化烯烃和炔烃立体定向反应，以高收率得到四氢和二氢噻吩衍生物。

  DOI：

  10.1039/c39860001073

文献信息

• MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME
  申请人：TABATA Masayoshi

  公开号：US20110224343A1

  公开（公告）日：2011-09-15

  The present invention provides a modifier for aromatic polyesters which enhances the melt fluidity of aromatic polyesters without a significant decrease in the heat resistance of the aromatic polyesters, and an aromatic polyester resin composition including the modifier for aromatic polyesters. The present invention relates to a modifier for aromatic polyesters comprising polyhydric phenol residues and residues of aromatic polycarboxylic acid, acid halide or acid anhydride thereof, and the modifier comprises a material having a structure composed of a first residue selected from the group consisting of divalent residues represented by Formula (I): —Ar—W 1 x —Ar— and by Formula (II): —Ar—, the first residues being bonded to two identical or different second residues selected from the group consisting of monovalent residues represented by Formula (III): and monovalent residues represented by Formula (IV): —O—C(O)—R 7 —.

  本发明提供了一种用于芳香族聚酯的改性剂，可以增强芳香族聚酯的熔融流动性，而不明显降低芳香族聚酯的耐热性，以及包括该改性剂的芳香族聚酯树脂组合物。本发明涉及一种用于芳香族聚酯的改性剂，包括多羟基酚残基和芳香族多羧酸、酸卤或其酸酐残基，该改性剂包括具有以下结构的材料：第一残基，选择自由式(I)所代表的二价残基：—Ar—W1x—Ar—和自由式(II)所代表的：—Ar—，第一残基与选择自由式(III)所代表的单价残基：和自由式(IV)所代表的单价残基：—O—C(O)—R7—的两个相同或不同的第二残基结合。
• Chloromethyl trimethylsilylmethyl sulphide as a parent thiocarbonyl ylide synthon. A simple synthesis of dihydro- and tetrahydro-thiophenes
  作者：Akira Hosomi、Yumiko Matsuyama、Hideki Sakurai

  DOI：10.1039/c39860001073

  日期：——

  Chloromethyl trimethylsilylmethyl sulphide acts as a parent thiocarbonyl ylide synthon and reacts stereospecifically with activated alkenes and alkynes, catalysed by caesium fluoride, in acetonitrile at room temperature to give tetrahydro- and dihydro-thiophene derivatives in good yields.

  氯甲基三甲基甲硅烷基甲基硫化物充当母体硫代羰基内酯的合成子，并在室温下在乙腈中与氟化铯催化的活化烯烃和炔烃立体定向反应，以高收率得到四氢和二氢噻吩衍生物。
• AROMATIC POLYESTER
  申请人：Muroran Institute of Technology

  公开号：EP2479203A1

  公开（公告）日：2012-07-25

  The present invention provides an aromatic polyester which is substantially free from the occurrence of coloration and retains significantly high transparency even after being thermally processed at high temperature and which has high flowability. The aromatic polyester contains a polyhydric phenol residue and a residue of any one of aromatic polycarboxylic acid, halide thereof, and anhydride thereof, and terminals of the aromatic polyester have a structure represented by the formula -C(O)-R. The aromatic polyester has an end-capping rate of 90% or higher and a weight average molecular weight (Mw) ranging from 3,000 to 1,000,000.

  本发明提供了一种芳香族聚酯，该聚酯基本上不会发生着色，即使在高温热加工后仍能保持明显的高透明度，并且具有高流动性。芳香族聚酯含有多羟基苯酚残留物和芳香族多羧酸、其卤化物和其酸酐中任意一种的残留物，芳香族聚酯的端基具有式 -C(O)-R 所代表的结构。芳香族聚酯的端盖率为 90% 或更高，重量平均分子量（Mw）为 3,000 至 1,000,000 之间。
• BIOTIN. V. cis-3,4-DIAMINOTHIOPHANE
  作者：B. R. BAKER、MERLE V. QUERRY、S. R. SAFIR、W. L. McEWEN、SEYMOUR BERNSTEIN

  DOI：10.1021/jo01165a022

  日期：1947.1
• BIOTIN. II. 3,4-trans-DIAMINOTHIOPHANE
  作者：GEORGE BOSWORTH BROWN、B. R. BAKER、SEYMOUR BERNSTEIN、S. R. SAFIR

  DOI：10.1021/jo01165a019

  日期：1947.1