N-(3,4-dichlorophenyl)-N'-(4,5,6,7-tetrahydrobenzo[b]thiophene-yl-2-sulfonyl)urea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3,4-dichlorophenyl)-N'-(4,5,6,7-tetrahydrobenzo[b]thiophene-yl-2-sulfonyl)urea
• 英文别名: 1-(3,4-Dichlorophenyl)-3-(4,5,6,7-tetrahydro-1-benzothiophen-2-ylsulfonyl)urea
• 化学式: C₁₅H₁₄Cl₂N₂O₃S₂
• 分子量: 405.326
• InChiKey: IKKUNLRMMWKWCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4,5,6,7-四氢-1-苯并噻吩 在 氯磺酸 、 ammonium hydroxide 、 sodium hydroxide 作用下， 以 氯仿 、 丙酮 为溶剂， 反应 4.0h， 生成 N-(3,4-dichlorophenyl)-N'-(4,5,6,7-tetrahydrobenzo[b]thiophene-yl-2-sulfonyl)urea
  参考文献：
  名称：

  Sulfonylureas: a new class of cancer chemotherapeutic agents

  摘要：

  This study summarizes the antitumor properties of a number of sulofenur thiophene analogs against subcutaneously implanted 6C3HED lymphosarcoma with structural modification of the aryl moiety of the sulfonamide portion of the diarylsulfonylureas. The spectrum of activity of N-(p-chlorophenyl)-N'-[(5-methoxy-2-thienyl)sulfonyl]urea in the HXGC3, VRC5, CX-1, and LX-1 cell lines is also presented.

  DOI：

  10.1021/jm00094a013

文献信息

• Sulfonylureas: a new class of cancer chemotherapeutic agents
  作者：Fariborz Mohamadi、Michael M. Spees、Gerald B. Grindey

  DOI：10.1021/jm00094a013

  日期：1992.8

  This study summarizes the antitumor properties of a number of sulofenur thiophene analogs against subcutaneously implanted 6C3HED lymphosarcoma with structural modification of the aryl moiety of the sulfonamide portion of the diarylsulfonylureas. The spectrum of activity of N-(p-chlorophenyl)-N'-[(5-methoxy-2-thienyl)sulfonyl]urea in the HXGC3, VRC5, CX-1, and LX-1 cell lines is also presented.