3-hydroxy-3-phenyl-1-indanone | 61765-23-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 3-hydroxy-3-phenyl-1-indanone
• 英文别名: 3-hydroxy-3-phenylindanone；3-Hydroxy-3-phenyl-2,3-dihydro-1H-inden-1-one；3-hydroxy-3-phenyl-2H-inden-1-one
• CAS: 61765-23-9
• 化学式: C₁₅H₁₂O₂
• 分子量: 224.259
• InChiKey: XECKXIOQDQLSBL-UHFFFAOYSA-N

物化性质

• 沸点：
  411.0±44.0 °C(Predicted)
• 密度：
  1.284±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(2-hydroxyphenyl)ethanone benzoylhydrazone 在 水 、 lead(IV) tetraacetate 、 sodium hydroxide 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 反应 0.03h， 生成 3-hydroxy-3-phenyl-1-indanone
  参考文献：
  名称：

  Regioselective quadruple domino aldolization/aldol condensation/Michael/SNAr-cyclization: construction of hexacyclic indeno-fused C-nor-D-homo-steroid frameworks

  摘要：

  An operationally simple and highly atom-economic anionic quadruple domino reaction sequence for the synthesis of hexacyclic indeno-fused naphthalene/quinoline molecules having structural resemblance with the C-nor-D-homo-steroid nucleus has been developed. Promoter and solvent specificity, regioselectivity and mechanistic details were experimentally established. Catalyst concentration and solvent dependent switching of domino steps creating four new C-C bonds are discussed. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.01.059

文献信息

• NHPI and palladium cocatalyzed aerobic oxidative acylation of arenes through a radical process
  作者：Yu-Feng Liang、Xiaoyang Wang、Conghui Tang、Tao Shen、Jianzhong Liu、Ning Jiao

  DOI：10.1039/c5cc08945j

  日期：——

  Molecular oxygen, the most environmentally friendly oxidant, was used as the terminal oxidant for palladium-catalyzed radical oxidative acylation of arenes.

  分子氧气，作为最环保的氧化剂，被用作钯催化的芳烃自由基氧化酰化反应的末端氧化剂。
• Direct Synthesis of 1-Indanones via Pd-Catalyzed Olefination and Ethylene Glycol-Promoted Aldol-Type Annulation Cascade
  作者：Jiwu Ruan、Jonathan A. Iggo、Jianliang Xiao

  DOI：10.1021/ol102756m

  日期：2011.1.21

  A wide range of multisubstituted 1-indanones of potential pharmaceutical use were synthesized in a one-pot fashion in moderate to excellent yields via palladium catalysis in ethylene glycol. The Heck reaction first installs an enol functionality on the aromatic ring; this is followed by an ethylene glycol promoted aldol-type annulation with a neighboring carbonyl group, resulting in the formation of various 1-indanones.