thiodiglycolic acid monomethyl ester chloride | 61363-69-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: thiodiglycolic acid monomethyl ester chloride
• 英文别名: thiodiglycolic acid monomethylester chloride；methyl 2-(chloroformylmethylthio)acetate；2-(chloroformylmethylthio)-acetic acid methyl ester；Methyl-2--acetat；Methyl-2-(chloroformylmethylthio)-acetat；Methyl-2-(chlorformylmethylthio)-acetat；Methyl [(2-chloro-2-oxoethyl)sulfanyl]acetate；methyl 2-(2-chloro-2-oxoethyl)sulfanylacetate
• CAS: 61363-69-7
• 化学式: C₅H₇ClO₃S
• 分子量: 182.628
• InChiKey: WECJPCQWSIRJIV-UHFFFAOYSA-N

物化性质

• 沸点：
  133 °C(Press: 24 Torr)
• 密度：
  1.332±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  68.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  thiodiglycolic acid monomethyl ester chloride 以51%的产率得到
  参考文献：
  名称：

  J. ORG. CHEM. , 1977, 42, NO 7, 1163-1169

  摘要：

  DOI：
• 作为产物：
  描述：

  2-((2-甲氧基-2-氧代乙基)硫代)乙酸 在 氯化亚砜 作用下， 生成 thiodiglycolic acid monomethyl ester chloride
  参考文献：
  名称：

  Notes-Sulfonamides and Some Related Materials

  摘要：

  DOI：

  10.1021/jo01068a600

文献信息

• 3-heteroaliphatyl- and 3-hetero(aryl)aliphatyl-2(1H)-quinolone
  申请人：Ciba-Geigy Corporation

  公开号：US05633379A1

  公开（公告）日：1997-05-27

  3-Heteroaliphatyl- and 3-hetero(aryl)aliphatyl-2(1H)quinolone derivatives of formula I ##STR1## wherein the radicals R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently of the others hydrogen, an aliphatic hydrocarbon radical, free or etherified hydroxy, mercapto or etherified and/or oxidised mercapto, unsubstituted or aliphaticaliy substituted amino, nitro, free or esterified or amidated carboxy, cyano, free or amidated sulfamoyl, halogen or trifluoromethyl, X is oxy or optionally oxidised thio, A is a divalent aliphatic radical and R.sub.5 is an optionally partially hydrogenated aryl or heteroaryl radical that is unsubstituted or substituted by aliphatic or araliphatic hydrocarbon radicals, by free or etherified hydroxy, by mercapto or etherified and/or oxidised mercapto, by unsubstituted or aliphatically substituted amino, by aliphatic acyl, by free or esterified or amidated carboxy, by cyano, by free or amidated sulfamoyl, by halogen and/or by trifluoromethyl; free or etherified hydroxymethyl; cyano; or free or esterified or amidated carboxy, and tautomers and/or salts thereof, have antagonistic properties with respect to excitatory amino acids and can be used for the treatment of pathological conditions that are responsive to glycine-antagonistic blocking of NMDA-sensitive receptors.

  公式I的3-杂原基脂肪基和3-杂(芳基)脂肪基-2(1H)喹啉酮衍生物，其中基团R.sub.1、R.sub.2、R.sub.3和R.sub.4各自独立地是氢、脂肪烃基、游离或醚化的羟基、巯基或醚化和/或氧化的巯基、未取代或脂肪基取代的氨基、硝基、游离或酯化或酰胺化的羧基、氰基、游离或酰胺化的磺胺基、卤素或三氟甲基，X是氧或可选择氧化的硫，A是二价脂肪基，R.sub.5是未取代或被脂肪或芳基脂肪基取代、游离或醚化的羟基、巯基或醚化和/或氧化的巯基、未取代或脂肪基取代的氨基、脂肪酰基、游离或酯化或酰胺化的羧基、氰基、游离或酰胺化的磺胺基、卤素和/或三氟甲基取代的可选择部分氢化的芳基或杂原基脂肪基，游离或醚化的羟甲基；氰基；或游离或酯化或酰胺化的羧基，以及其互变异构体和/或盐，具有对兴奋性氨基酸的拮抗性质，并可用于治疗对甘氨酸-拮抗性NMDA敏感受体的阻断有反应的病理条件。
• Reaction of mixed carboxylic anhydrides with grignard reagents
  作者：T. Terasawa、T. Okada

  DOI：10.1016/0040-4020(77)80298-6

  日期：1977.1

  The low-temperature Grignard reaction of mixed carboxylic anhydrides derived from acid chlorides and o-anisic acid to the general synthesis of keto esters is demonstrated for compounds 1–6, although, some limitations on substrate and Grignard reagent species are also encountered; attempts in the oxa series 2 are unsuccessful, and reaction with ω-phenylpropyl Grignard species for 1 and 4 shows a drastic

  对于化合物1-6，已证明了酰氯和邻茴香酸的混合羧酸酐的低温格氏反应与酮酯的一般合成，尽管在底物和格氏试剂种类上也遇到了一些限制。在氧杂一系列尝试2是不成功的，并与ω苯丙基格利雅物种反应1只4示出了在酮酯为产率的急剧下降米甲氧基类似物。异常行为可能与特定类型的金属配位配合物的另一种类型有关，该配合物包括正确位于基质或试剂中的醚氧原子
• Oxa- and thia-steroids
  申请人：Shionogi & Co., Ltd.

  公开号：US04083852A1

  公开（公告）日：1978-04-11

  16-Oxa- and 16-thia-D-homo-estrogen derivatives useful as postcoital oral contraceptives which are produced by total synthesis from 1-vinyltetralin-1-ols or their thiuronium derivatives on reactions with 4-substituted tetrahydropyran- or tetrahydrothiopyran-3,5-diones, and subsequent appropriate modifications.

  16-Oxa-和16-thia-D-homo-雌激素衍生物是一种有用的事后口服避孕药，它们是通过从1-乙烯基四氢萘酚或其硫脲衍生物开始的全合成反应中，与4-取代四氢吡喃-或四氢噻吩-3,5-二酮反应，然后进行适当的修饰而产生的。
• Novel type of oxa- and thia-steroids
  申请人：Shionogi & Co., Ltd.

  公开号：US04130565A1

  公开（公告）日：1978-12-19

  16-Oxa- and 16-thia-D-homo-estrogen derivatives useful as postcoital oral contraceptives which are produced by total synthesis from 1-vinyltetralin-1-ols or their thiuronium derivatives on reactions with 4-substituted tetrahydropyran- or tetrahydrothiopyran-3,5-diones, and subsequent appropriate modifications.

  16-氧-和16-硫-D-同型雌激素衍生物，可用作事后口服避孕药，这些衍生物通过从1-乙烯基四氢萘-1-醇或其硫脲衍生物开始的全合成反应中，与4-取代的四氢吡喃-或四氢噻吩-3,5-二酮反应，随后进行适当的修饰而制得。
• Kaluz, Stefan; Toma, Stefan, Gazzetta Chimica Italiana, 1987, vol. 117, # 9, p. 529 - 532
  作者：Kaluz, Stefan、Toma, Stefan

  DOI：——

  日期：——