2-[2-[Tert-butyl(diphenyl)silyl]oxyethyl-[2-(5-methyl-2,4-dioxopyrimidin-1-yl)acetyl]amino]acetic acid | 199998-47-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[2-[Tert-butyl(diphenyl)silyl]oxyethyl-[2-(5-methyl-2,4-dioxopyrimidin-1-yl)acetyl]amino]acetic acid
• CAS: 199998-47-5
• 化学式: C₂₇H₃₃N₃O₆Si
• 分子量: 523.661
• InChiKey: ZDFRTWGJVGDWPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.33
• 重原子数：
  37
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-[2-[Tert-butyl(diphenyl)silyl]oxyethyl-[2-(5-methyl-2,4-dioxopyrimidin-1-yl)acetyl]amino]acetic acid 在 四丁基氟化铵 作用下， 生成
  参考文献：
  名称：

  Synthesis and Hybridization Properties of Modified Oligonucleotides with PNA-DNA Dimer Blocks

  摘要：

  Different modified PNA-DNA dimer-analogous synthons (I and II) were synthesized as phosphoramidites. These dimer units were assembled by a 5'-modified deoxythymidine and a modified PNA monomer. These synthons were used in the routine coupling procedure for oligonucleotides. Therefore no PNA coupling chemistry is necessary to synthesize PNA-DNA chimeric oligonucleotides. Various deoxyoligonucleotides were synthesized introducing the dimer blocks I and II at different positions in the sequences. Melting temperatures of the modified oligonucleotides with their complementary DNA analogues were determined.

  DOI：

  10.1080/07328319708006120
• 作为产物：
  描述：

  2-((tert-butyldiphenylsilyl)oxy)ethanamine 在 lithium hydroxide 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 9.0h， 生成 2-[2-[Tert-butyl(diphenyl)silyl]oxyethyl-[2-(5-methyl-2,4-dioxopyrimidin-1-yl)acetyl]amino]acetic acid
  参考文献：
  名称：

  Synthesis and Hybridization Properties of Modified Oligonucleotides with PNA-DNA Dimer Blocks

  摘要：

  Different modified PNA-DNA dimer-analogous synthons (I and II) were synthesized as phosphoramidites. These dimer units were assembled by a 5'-modified deoxythymidine and a modified PNA monomer. These synthons were used in the routine coupling procedure for oligonucleotides. Therefore no PNA coupling chemistry is necessary to synthesize PNA-DNA chimeric oligonucleotides. Various deoxyoligonucleotides were synthesized introducing the dimer blocks I and II at different positions in the sequences. Melting temperatures of the modified oligonucleotides with their complementary DNA analogues were determined.

  DOI：

  10.1080/07328319708006120