(2E,2′E)-3,3′-(1,4-phenylene)bis(1-(naphthalen-1-yl)prop-2-en-1-one) | 1584741-43-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (2E,2′E)-3,3′-(1,4-phenylene)bis(1-(naphthalen-1-yl)prop-2-en-1-one)
• 英文别名: (E)-1-naphthalen-1-yl-3-[4-[(E)-3-naphthalen-1-yl-3-oxoprop-1-enyl]phenyl]prop-2-en-1-one
• CAS: 1584741-43-4
• 化学式: C₃₂H₂₂O₂
• 分子量: 438.525
• InChiKey: FRJUSNJBEHTICZ-FLFKKZLDSA-N

物化性质

• 沸点：
  681.5±55.0 °C(Predicted)
• 密度：
  1.223±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-萘乙酮 、 对苯二甲醛 在 potassium hydroxide 作用下， 以 甲醇 为溶剂， 以69%的产率得到(2E,2′E)-3,3′-(1,4-phenylene)bis(1-(naphthalen-1-yl)prop-2-en-1-one)
  参考文献：
  名称：

  Symmetric Bis-chalcones as a New Type of Breast Cancer Resistance Protein Inhibitors with a Mechanism Different from That of Chromones

  摘要：

  Potent ABCG2 inhibitors were recently identified as asymmetric chromones with different types of substituents. We here synthesized symmetric bis-chalcones that were differently substituted and screened for their ability to inhibit mitoxantrone efflux from ABCG2-transfected HEK293 cells. Potent bis-chalcone inhibitors were identified, the efficiency depending on both position of the central ketone groups and the number and positions of lateral methoxy substituents. The best derivative, namely, 1p, was selective for ABCG2 over P-glycoprotein and MRP1, appeared not to be transported by ABCG2, and was at least as active on various drug-selected cancer cells overexpressing ABCG2. Compound 1p stimulated the ABCG2 basal ATPase activity by contrast to a chromone lead that inhibited it, suggesting different mechanisms of interaction. Combination of both types of inhibitors produced synergistic effects, leading to complete inhibition at very low

  DOI：

  10.1021/jm401879z

文献信息

• Organic electroluminescent device
  申请人：Yoshitake Osamu

  公开号：US20070012935A1

  公开（公告）日：2007-01-18

  This invention provides an organic electroluminescent element (organic EL element) utilizing phosphorescence which emits light efficiently with high luminance at low current density, shows good driving stability and is applicable to display devices such as flat panel displays and illuminating devices. The element comprises an anode, organic layers and a cathode piled one upon another on a substrate, at least one of the organic layers is a light-emitting layer containing a host material and a dopant material and a pyrazole-derived compound having 2-4 pyrazole structures represented by the following formula I in the same molecule is used as said host material; wherein, Ar 1 -Ar 3 are independently hydrogen or substituted or unsubstituted aromatic hydrocarbon groups and at least one of Ar 1 -Ar 3 is a group other than hydrogen.

  这项发明提供了一种利用磷光的有机电致发光元件（有机EL元件），其在低电流密度下高效地发光，显示良好的驱动稳定性，并适用于如平板显示器和照明设备等显示设备。该元件包括在基板上堆叠的阳极、有机层和阴极，其中至少一个有机层是包含主体材料和掺杂剂材料以及具有以下式I所表示的2-4个吡唑结构的吡唑衍生物化合物作为所述主体材料的发光层;其中，Ar1-Ar3独立地为氢或取代或未取代的芳香烃基团，且Ar1-Ar3中至少有一个基团不为氢。
• US7582364B2
  申请人：——

  公开号：US7582364B2

  公开（公告）日：2009-09-01