8-[[4-[2-(2-Tert-butyltetrazol-5-yl)phenyl]phenyl]methyl]-2,4,6-trimethyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one | 1027570-19-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 8-[[4-[2-(2-Tert-butyltetrazol-5-yl)phenyl]phenyl]methyl]-2,4,6-trimethyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
• CAS: 1027570-19-9
• 化学式: C₂₈H₃₁N₇O
• 分子量: 481.6
• InChiKey: WESAGFJCIAKKDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  36
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  89.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  8-[[4-[2-(2-Tert-butyltetrazol-5-yl)phenyl]phenyl]methyl]-2,4,6-trimethyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one 在 甲烷磺酸 作用下， 以 甲苯 为溶剂， 反应 24.0h， 生成 2,4,6-trimethyl-5,6,8-trihydro-8-[[2'-(1H-tetrazol-5-yl)[1,1-biphenyl]-4-yl]methyl]-7H-pyrido[2,3-d]pyrimidin-7-one
  参考文献：
  名称：

  Pyrido[2,3-d]pyrimidine Angiotensin II Antagonists

  摘要：

  A series of pyrido[2,3-d]pyrimidine angiotensin II (A II) antagonists was synthesized and tested for antagonism of A II. Compounds with a biphenylyltetrazole pharmacophore and small alkyl groups at the 2- and ii-positions Of the pyridopyrimidine ring were found to be the most potent in an AT(1) receptor binding assay and in blocking the A II presser response in anesthetized, ganglion-blocked A II-infused rats. 5,8-Dihydro-2,4-dimethyl-8-[(2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl)methyl] pyrido[2,3-d]pyrimidin-7(6H)-one (4a) was one of the more potent compounds in the binding assay and was the most efficacious compound in the A II-infused rat model. Further study of 4a;in Goldblatt (2K-1C) rats showed the compound to have oral bioavailability and to be an efficacious and potent compound in a high renin form of hypertension.

  DOI：

  10.1021/jm00030a013
• 作为产物：
  描述：

  4-羟基-2,6-二甲基-5-嘧啶丙酸乙酯 在 四(三苯基膦)钯 、 碳酸氢钠 、 sodium carbonate 、 N,N-二甲基苯胺 、 lithium diisopropyl amide 、 三氯氧磷 作用下， 以 乙醇 、 甲苯 、 正丁醇 为溶剂， 反应 82.75h， 生成 8-[[4-[2-(2-Tert-butyltetrazol-5-yl)phenyl]phenyl]methyl]-2,4,6-trimethyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
  参考文献：
  名称：

  Pyrido[2,3-d]pyrimidine Angiotensin II Antagonists

  摘要：

  A series of pyrido[2,3-d]pyrimidine angiotensin II (A II) antagonists was synthesized and tested for antagonism of A II. Compounds with a biphenylyltetrazole pharmacophore and small alkyl groups at the 2- and ii-positions Of the pyridopyrimidine ring were found to be the most potent in an AT(1) receptor binding assay and in blocking the A II presser response in anesthetized, ganglion-blocked A II-infused rats. 5,8-Dihydro-2,4-dimethyl-8-[(2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl)methyl] pyrido[2,3-d]pyrimidin-7(6H)-one (4a) was one of the more potent compounds in the binding assay and was the most efficacious compound in the A II-infused rat model. Further study of 4a;in Goldblatt (2K-1C) rats showed the compound to have oral bioavailability and to be an efficacious and potent compound in a high renin form of hypertension.

  DOI：

  10.1021/jm00030a013

文献信息

• Pyrido[2,3-d]pyrimidine Angiotensin II Antagonists
  作者：John W. Ellingboe、Madelene Antane、Thomas T. Nguyen、Michael D. Collini、Schuyler Antane、Reinhold Bender、Dale Hartupee、Valerie White、John McCallum

  DOI：10.1021/jm00030a013

  日期：1994.2

  A series of pyrido[2,3-d]pyrimidine angiotensin II (A II) antagonists was synthesized and tested for antagonism of A II. Compounds with a biphenylyltetrazole pharmacophore and small alkyl groups at the 2- and ii-positions Of the pyridopyrimidine ring were found to be the most potent in an AT(1) receptor binding assay and in blocking the A II presser response in anesthetized, ganglion-blocked A II-infused rats. 5,8-Dihydro-2,4-dimethyl-8-[(2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl)methyl] pyrido[2,3-d]pyrimidin-7(6H)-one (4a) was one of the more potent compounds in the binding assay and was the most efficacious compound in the A II-infused rat model. Further study of 4a;in Goldblatt (2K-1C) rats showed the compound to have oral bioavailability and to be an efficacious and potent compound in a high renin form of hypertension.