3-oxo-docosanoic acid methyl ester | 14531-36-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: 3-oxo-docosanoic acid methyl ester
• 英文别名: 3-Oxo-docosansaeure-methylester；3-Oxodocosansaeuremethylester；Methyl 3-oxodocosanoate
• CAS: 14531-36-3
• 化学式: C₂₃H₄₄O₃
• 分子量: 368.601
• InChiKey: FOXUNHQJSRLJBF-UHFFFAOYSA-N

物化性质

• 熔点：
  62.6 °C
• 沸点：
  389.3±10.0 °C(Predicted)
• 密度：
  0.901±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.5
• 重原子数：
  26
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-oxo-docosanoic acid methyl ester 在 potassium carbonate 、 2-戊酮 作用下， 生成 5-oxo-tetracosanoic acid methyl ester
  参考文献：
  名称：

  Lamberton, Australian Journal of Chemistry, 1959, vol. 12, p. 224,230

  摘要：

  DOI：
• 作为产物：
  描述：

  trans-2-docosenoic acid methyl ester 、 间氯过氧苯甲酸 以70%的产率得到
  参考文献：
  名称：

  ANSARI A. A.; AHMAD F.; OSMAN S. M., FETTE, SEIFEN, ANSTRICHMITTEL, 1977, 79, NO 8, 328-330

  摘要：

  DOI：

文献信息

• Staellberg-Stenhagen, Arkiv foer Kemi, 1946, vol. 20 A, # 19, p. 5,7, 12
  作者：Staellberg-Stenhagen

  DOI：——

  日期：——
• Stenhagen, Arkiv foer Kemi, 1952, vol. 3, p. 381,382
  作者：Stenhagen

  DOI：——

  日期：——
• Staellberg-Stenhagen, Arkiv foer Kemi, 1947, vol. 23 A, # 15, p. 8
  作者：Staellberg-Stenhagen

  DOI：——

  日期：——
• Skogh, Acta Chemica Scandinavica (1947), 1952, vol. 6, p. 809,812
  作者：Skogh

  DOI：——

  日期：——
• Hospital-acquired infections among chronic hemodialysis patients
  作者：Erika M.C. D'Agata、David B. Mount、Valerie Thayer、William Schaffner

  DOI：10.1016/s0272-6386(00)70044-8

  日期：2000.6

  The epidemiological characteristics of nosocomial infections among patients requiring chronic hemodialysis, a high-risk and rapidly growing population, have not been fully elucidated. During a 30 month cohort study, rates of bloodstream infections (BSIs), urinary tract infections (UTIs), pneumonia, and diarrhea caused by Clostridium difficile and the distribution of pathogens among hospitalized chronic hemodialysis patients were compared with hospitalized patients not requiring chronic hemodialysis, To identify risk factors for developing a nosocomial infection among chronic hemodialysis patients, a matched case-control study was performed. A total of 1,557 nosocomial infections were detected during 1,317 of 68,361 admissions (2%). Of these, 47 nosocomial infections occurred in chronic hemodialysis patients during 31 of 578 admissions (5%). Nosocomial infections were significantly more frequent among the chronic hemodialysis group (9.1/1,000 patient-days) compared with the non-chronic hemodialysis group (3.8/1,000 patient-days; relative risk [RR], 2.4; 95% confidence interval [CI], 1.8 to 3.2; P < 0.001). UTIs were the most common nosocomial infections among chronic hemodialysis patients, accounting for 47% of all infections in this population. UTIs were significantly more common among chronic hemodialysis patients (4.2/1,000 patient-days) compared with non-chronic hemodialysis patients (0.7/1,000 patient-days; RR, 6.2; 95% CI, 3.8 to 9.5; P < 0.001). Among chronic hemodialysis patients, Candida spp and enterococci were the most common pathogens in contrast to coagulase-negative staphylococci and Staphylococcus aureus among patients not requiring hemodialysis. Using conditional logistic regression, a greater index of comorbidity was significantly associated with nosocomial infections among the chronic hemodialysis population (odds ratio, 3.6; 95% CI, 1.2 to 10.7; P = 0.02), Chronic hemodialysis patients are at a substantially greater risk for developing a nosocomial infection compared with other hospitalized patients. (C) 2000 by the National Kidney Foundation, Inc.