2-(tert-Butyl-dimethyl-silanyloxy)-5-(3-chloro-phenyl)-6-methyl-nicotinonitrile | 641621-28-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(tert-Butyl-dimethyl-silanyloxy)-5-(3-chloro-phenyl)-6-methyl-nicotinonitrile
• CAS: 641621-28-5
• 化学式: C₁₉H₂₃ClN₂OSi
• 分子量: 358.943
• InChiKey: PGLYEYGCYXVYGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.97
• 重原子数：
  24.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  45.91
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-(tert-Butyl-dimethyl-silanyloxy)-5-(3-chloro-phenyl)-6-methyl-nicotinonitrile 在 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 作用下， 以 四氯化碳 为溶剂， 生成
  参考文献：
  名称：

  Pyridone-Containing farnesyltransferase inhibitors: synthesis and biological evaluation

  摘要：

  Farnesyltransferase inhibitors (FTIs) have been developed as potential anti-cancer agents due to their efficacy in blocking malignant growth in a variety of murine models of human tumors. To that end, we have developed a series of pyridone farnesyltransferase inhibitors with potent in vitro and cellular activity. The synthesis, SAR and biological properties of these compounds will be discussed. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.08.058
• 作为产物：
  描述：

  3-氰基-6-甲基-2(1H)-吡啶酮 在 咪唑 、 N-溴代丁二酰亚胺(NBS) 、 四(三苯基膦)钯 、 sodium carbonate 、 lithium chloride 作用下， 以 乙醇 、 1,2-二氯乙烷 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 生成 2-(tert-Butyl-dimethyl-silanyloxy)-5-(3-chloro-phenyl)-6-methyl-nicotinonitrile
  参考文献：
  名称：

  Pyridone-Containing farnesyltransferase inhibitors: synthesis and biological evaluation

  摘要：

  Farnesyltransferase inhibitors (FTIs) have been developed as potential anti-cancer agents due to their efficacy in blocking malignant growth in a variety of murine models of human tumors. To that end, we have developed a series of pyridone farnesyltransferase inhibitors with potent in vitro and cellular activity. The synthesis, SAR and biological properties of these compounds will be discussed. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.08.058