24-bromocholane | 56439-81-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 24-bromocholane
• 英文别名: 24-bromo-5β-cholane；24-Brom-5β-cholan；(20R)-24-Bromo-5beta-cholane；(5S,8R,9S,10S,13R,14S,17R)-17-[(2R)-5-bromopentan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene
• CAS: 56439-81-7
• 化学式: C₂₄H₄₁Br
• 分子量: 409.494
• InChiKey: LNDWQTHGVGFOEB-OBUPQJQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  24-bromocholane 、 三苯基膦 以 氯苯 为溶剂， 反应 48.0h， 生成 24-(triphenylphosphoniumyl)cholane bromide
  参考文献：
  名称：

  Cosalane Analogs with Enhanced Potencies as Inhibitors of HIV-1 Protease and Integrase

  摘要：

  Several new analogues of the novel anti-HIV agent cosalane have been synthesized and evaluated as inhibitors of HIV-1 integrase and protease, HIV-1 replication, HIV-1 and HIV-2 cytopathicity, HIV-1- and HIV-2-mediated syncytium formation, and cytopathicity of a variety of human pathogenic viruses. The congeners displayed enhanced potencies relative to cosalane itself as inhibitors of HIV-1 integrase and protease. The two most potent analogues against HIV-1 integrase displayed IC50 values of 2.2 mu M, while the three most potent compounds against HIV-1 protease had IC50 values in the 0.35-0.39 mu M range. In addition to its activity against HIV-1 and HIV-2 cytopathicity, cosalane inhibited the cytopathic effects of herpes simplex virus-1, herpes simplex virus-2, and human cytomegalovirus at concentrations that were well below the cytotoxic concentrations. Potentially useful antiviral activities were also revealed for some of the new cosalane congeners against influenza virus, Junin virus, and Tacaribe virus.

  DOI：

  10.1021/jm00003a007
• 作为产物：
  描述：

  5-Beta-卓兰-24-醇 在 五溴化磷 作用下， 生成 24-bromocholane
  参考文献：
  名称：

  Comparative studies of ‘bile salts’. 6. Partial synthesis of coprostanic acid, a ‘stem acid’ of primitive bile salts

  摘要：

  DOI：

  10.1042/bj0520588

文献信息

• Comparative studies of ‘bile salts’. 6. Partial synthesis of coprostanic acid, a ‘stem acid’ of primitive bile salts
  作者：R. J. Bridgwater、G. A. D. Haslewood

  DOI：10.1042/bj0520588

  日期：1952.12.1
• Steroidal triphenyl phosphonium salts, versatile intermediates for side chain modifications
  作者：J.E. Herz、Sergio Cruz Montalvo

  DOI：10.1016/0039-128x(71)90080-8

  日期：1971.6
• Cosalane Analogs with Enhanced Potencies as Inhibitors of HIV-1 Protease and Integrase
  作者：Mark Cushman、W. Marek Golebiewski、Yves Pommier、Abhijit Mazunder、Diane Reymen、Erik De Clercq、Lisa Grahm、William G. Rice

  DOI：10.1021/jm00003a007

  日期：1995.2

  Several new analogues of the novel anti-HIV agent cosalane have been synthesized and evaluated as inhibitors of HIV-1 integrase and protease, HIV-1 replication, HIV-1 and HIV-2 cytopathicity, HIV-1- and HIV-2-mediated syncytium formation, and cytopathicity of a variety of human pathogenic viruses. The congeners displayed enhanced potencies relative to cosalane itself as inhibitors of HIV-1 integrase and protease. The two most potent analogues against HIV-1 integrase displayed IC50 values of 2.2 mu M, while the three most potent compounds against HIV-1 protease had IC50 values in the 0.35-0.39 mu M range. In addition to its activity against HIV-1 and HIV-2 cytopathicity, cosalane inhibited the cytopathic effects of herpes simplex virus-1, herpes simplex virus-2, and human cytomegalovirus at concentrations that were well below the cytotoxic concentrations. Potentially useful antiviral activities were also revealed for some of the new cosalane congeners against influenza virus, Junin virus, and Tacaribe virus.