(2R)-1-[4-(3-{4-[5-(cyclopentylmethyl)-1,2,4-oxadiazol-3-yl]-3-fluorophenoxy}propyl)-1-piperazinyl]-1-oxo-2-propanamine | 360553-15-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-1-[4-(3-{4-[5-(cyclopentylmethyl)-1,2,4-oxadiazol-3-yl]-3-fluorophenoxy}propyl)-1-piperazinyl]-1-oxo-2-propanamine
• 英文别名: (2R)-2-amino-1-[4-[3-[4-[5-(cyclopentylmethyl)-1,2,4-oxadiazol-3-yl]-3-fluorophenoxy]propyl]piperazin-1-yl]propan-1-one
• CAS: 360553-15-7
• 化学式: C₂₄H₃₄FN₅O₃
• 分子量: 459.564
• InChiKey: XJKSPBOUGJGZHR-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  97.7
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  3-(三氟甲基)苯甲酰氯 、 (2R)-1-[4-(3-{4-[5-(cyclopentylmethyl)-1,2,4-oxadiazol-3-yl]-3-fluorophenoxy}propyl)-1-piperazinyl]-1-oxo-2-propanamine 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 N-[(R)-2-(4-{3-[4-(5-Cyclopentylmethyl-[1,2,4]oxadiazol-3-yl)-3-fluoro-phenoxy]-propyl}-piperazin-1-yl)-1-methyl-2-oxo-ethyl]-2-(3-trifluoromethyl-phenyl)-acetamide
  参考文献：
  名称：

  Structure–activity relationships of non-imidazole H3 receptor ligands. Part 3: 5-Substituted 3-phenyl-1,2,4-oxadiazoles as potent antagonists

  摘要：

  Further SAR studies on novel histamine H-3 receptor antagonists are presented. Compound 14bb is a potent antagonist of both the rat cortical and human clone receptors, and is demonstrated to act functionally as an antagonist in an in vivo mouse dipsogenia model. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.11.038
• 作为产物：
  描述：

  4-(3-chloropropoxy)-2-fluorobenzonitrile 在 4-二甲氨基吡啶 、 盐酸羟胺 、 potassium carbonate 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 、 N,N-二异丙基乙胺 、 三氟乙酸 、 potassium iodide 作用下， 以 乙醇 、 二氯甲烷 、 丙酮 、 甲苯 、 丁酮 为溶剂， 生成 (2R)-1-[4-(3-{4-[5-(cyclopentylmethyl)-1,2,4-oxadiazol-3-yl]-3-fluorophenoxy}propyl)-1-piperazinyl]-1-oxo-2-propanamine
  参考文献：
  名称：

  Structure–activity relationships of non-imidazole H3 receptor ligands. Part 3: 5-Substituted 3-phenyl-1,2,4-oxadiazoles as potent antagonists

  摘要：

  Further SAR studies on novel histamine H-3 receptor antagonists are presented. Compound 14bb is a potent antagonist of both the rat cortical and human clone receptors, and is demonstrated to act functionally as an antagonist in an in vivo mouse dipsogenia model. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.11.038

文献信息

• Cyclic and bicyclic diamino histamine-3 receptor antagonists
  申请人：——

  公开号：US20010049367A1

  公开（公告）日：2001-12-06

  Compounds of formula (I) 1 compounds of formula (II) 2 compounds of formula (III) 3 and compounds of formula (IV) 4 or pharmaceutically acceptable salts thereof are useful as H 3 receptor antagonists. Processes to make the compounds and methods of treatment using the compounds are also disclosed.

  化合物的公式(I)1、公式(II)2、公式(III)3和公式(IV)4或其药学上可接受的盐被用作H3受体拮抗剂。还公开了制备这些化合物的方法以及使用这些化合物的治疗方法。
• US6559140B2
  申请人：——

  公开号：US6559140B2

  公开（公告）日：2003-05-06
• [EN] CYCLIC AND BICYCLIC DIAMINO HISTAMINE-3 RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DU RECEPTEUR D'HISTAMINE-3 DIAMINO CYCLIQUES ET BICYCLIQUES
  申请人：ABBOTT LAB

  公开号：WO2001066534A2

  公开（公告）日：2001-09-13

  Compounds of formula (I), compounds of formula (II), compounds of formula (III), and compounds of formula (IV), or pharmaceutically acceptable salts thereof are useful as H3 receptor antagonists. Processes to make the compounds and methods of treatment using the compounds are also disclosed.
• Structure–activity relationships of non-imidazole H3 receptor ligands. Part 3: 5-Substituted 3-phenyl-1,2,4-oxadiazoles as potent antagonists
  作者：Gregory A. Gfesser、Henry Zhang、Jurgen Dinges、Gerard B. Fox、Jia Bao Pan、Timothy A. Esbenshade、Betty B. Yao、David Witte、Thomas R. Miller、Chae-Hee Kang、Kathy M. Krueger、Youssef L. Bennani、Arthur A. Hancock、Ramin Faghih

  DOI：10.1016/j.bmcl.2003.11.038

  日期：2004.2

  Further SAR studies on novel histamine H-3 receptor antagonists are presented. Compound 14bb is a potent antagonist of both the rat cortical and human clone receptors, and is demonstrated to act functionally as an antagonist in an in vivo mouse dipsogenia model. (C) 2003 Elsevier Ltd. All rights reserved.