Boc-Met-N(CH3)2 | 83181-57-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Met-N(CH3)2
• 英文别名: tert-butyl [(1S)-1-[(dimethylamino)carbonyl]-3-(methylthio) propyl]carbamate；tert-butyl N-[(2S)-1-(dimethylamino)-4-methylsulfanyl-1-oxobutan-2-yl]carbamate
• CAS: 83181-57-1
• 化学式: C₁₂H₂₄N₂O₃S
• 分子量: 276.4
• InChiKey: XSDIKRULIWMAKO-VIFPVBQESA-N

物化性质

• 沸点：
  415.2±40.0 °C(Predicted)
• 密度：
  1.072±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  83.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Boc-Met-N(CH3)2 在 盐酸 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 、 溶剂黄146 为溶剂， 反应 26.0h， 生成 Boc-Leu-Met-N(CH3)2
  参考文献：
  名称：

  Structure-activity studies on the C-terminal amide of substance P

  摘要：

  Twelve C-terminal heptapeptide analogues of substance P have been synthesized by solid phase and by the classical solution method. The modifications concerned all the C-terminal primary amide of SP and should therefore help to understand the biological significance of this carboxamide, as evaluated by in vivo and in vitro bioassays. From the results it can be seen that not the slightest change of the two amide protons is tolerated without an important loss of activity: replacement of one or two amide protons with alkyl groups, extension of the amide to the hydrazide and its alkyl analogues, and exchange of the amide with an ester or a carboxylic acid all reduce the relative activity/affinity at least by 2-fold. It is not clear for what reason all these modifications produce such a drastic activity reduction.

  DOI：

  10.1021/jm00353a009
• 作为产物：
  描述：

  N-叔丁氧羰基-L-蛋氨酸二环己胺盐 以 四氢呋喃 、 水 为溶剂， 反应 0.03h， 生成 Boc-Met-N(CH3)2
  参考文献：
  名称：

  Structure-activity studies on the C-terminal amide of substance P

  摘要：

  Twelve C-terminal heptapeptide analogues of substance P have been synthesized by solid phase and by the classical solution method. The modifications concerned all the C-terminal primary amide of SP and should therefore help to understand the biological significance of this carboxamide, as evaluated by in vivo and in vitro bioassays. From the results it can be seen that not the slightest change of the two amide protons is tolerated without an important loss of activity: replacement of one or two amide protons with alkyl groups, extension of the amide to the hydrazide and its alkyl analogues, and exchange of the amide with an ester or a carboxylic acid all reduce the relative activity/affinity at least by 2-fold. It is not clear for what reason all these modifications produce such a drastic activity reduction.

  DOI：

  10.1021/jm00353a009

文献信息

• Ring-Opening Polymerization of Lactides Catalyzed by Natural Amino-Acid Based Zinc Catalysts
  作者：Donald J. Darensbourg、Osit Karroonnirun

  DOI：10.1021/ic902271x

  日期：2010.3.1

  to be dimeric with bridging phenoxide ligands. All zinc complexes were shown to be very effective catalysts for the ring-opening polymerization (ROP) of lactides at ambient temperature, producing polymers with controlled and narrow molecular weight distributions. These enantiomerically pure zinc complexes did not show selectivity toward either l- or d-lactide, that is, kd(obsd)/kl(obsd) ≈ 1. However

  使一系列源自天然氨基酸的手性NNO-三齿Schiff碱配体与锌（双-三甲基甲硅烷基酰胺）2反应，以提供已充分表征的金属配合物。这些衍生物之一进一步与对氟苯酚反应，生成酚盐配合物。X射线晶体学研究表明锌席夫碱酰胺络合物是单体，而对位氟酚盐配合物显示为具有桥接酚盐配体的二聚体。已显示所有锌络合物都是在环境温度下丙交酯开环聚合（ROP）的非常有效的催化剂，可生产分子量分布受控且较窄的聚合物。这些对映体纯的锌络合物对l-或d-丙交酯均没有选择性，即k d（ obsd ）/ k l（obsd） ≈1。但是，席夫碱配体上的空间取代基显示出对中度至极好的立体控制。外消旋-丙交酯的ROP 。异规聚丙交酯由具有P r的rac-丙交酯生成取决于所使用的催化剂和反应温度，该值在0.68至0.89的范围内。席夫碱配体上的取代基极大地影响了各种催化剂的反应性，而体积较大的取代基的速率得到了提高。