2-(methylamino)-3-(4-methoxyphenyl)propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(methylamino)-3-(4-methoxyphenyl)propanoic acid
• 英文别名: N,O-diMe-Tyr；N-Methyl-O-methyltyrosin；N-Methyl-4-methoxy-phenylalanin；N,O-dimethyl-tyrosine；α-Methylamino-β-(4-methoxy-phenyl)-propionsaeure；N,O-Dimethyl-tyrosin；4-Methoxy-methyl-DL-phenylalanin；3-(4-methoxyphenyl)-2-(methylazaniumyl)propanoate
• 化学式: C₁₁H₁₅NO₃
• 分子量: 209.245
• InChiKey: QESMMBKGCOSBNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(methylamino)-3-(4-methoxyphenyl)propanoic acid 在 氢溴酸 作用下， 生成 3-(4-hydroxyphenyl)-2-methylaminopropionic acid
  参考文献：
  名称：

  Friedmann; Gutmann, Biochemische Zeitschrift, 1910, vol. 27, p. 493

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(4-甲氧基亚苄基)丙二酸 在 sodium amalgam 、 乙醚 、 水 、 溴 作用下， 生成 2-(methylamino)-3-(4-methoxyphenyl)propanoic acid
  参考文献：
  名称：

  Friedmann; Gutmann, Biochemische Zeitschrift, 1910, vol. 27, p. 493

  摘要：

  DOI：
• 作为试剂：
  描述：

  2-trimethylsilylethoxymethyl 3-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate 、 2-(methylamino)-3-(4-methoxyphenyl)propanoic acid 在 2-(methylamino)-3-(4-methoxyphenyl)propanoic acid 作用下， 以88的产率得到N,O-dimethyltyrosine-O-Boc-threonine-OSEM
  参考文献：
  名称：

  J. Org. Chem. 1997, 62, 354-366

  摘要：

  DOI：

文献信息

• METHOD FOR SYNTHESIZING PEPTIDES IN CELL-FREE TRANSLATION SYSTEM
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：US20200040372A1

  公开（公告）日：2020-02-06

  An objective of the present invention is to provide methods of synthesizing peptides containing structurally diverse amino acids using cell-free translation systems, which can accomplish excellent translational efficiency as compared to conventional techniques (the conventional techniques being methods which involve preparing aminoacyl-tRNAs which do not have protecting groups outside the translation systems without using ARS, and then adding the prepared aminoacyl-tRNAs into translation systems). In the present invention, it was found that amino acid-containing peptides can be synthesized efficiently by protecting an amino acid linked to tRNA with an appropriate protecting group, and then performing the step of deprotecting the protecting group of the amino acid linked to tRNA and the step of peptide translation from a template nucleic acid in a cell-free translation system in parallel.

  本发明的一个目标是提供使用无细胞翻译系统合成含有结构多样的氨基酸的肽的方法，这些方法可以实现与传统技术相比出色的翻译效率（传统技术是指涉及在翻译系统外部准备没有保护基的氨酰-tRNA而不使用ARS的方法，然后将准备好的氨酰-tRNA添加到翻译系统中）。在本发明中，发现通过用适当的保护基保护与tRNA连接的氨基酸，然后并行进行去保护氨基酸与tRNA连接的保护基的步骤和从模板核酸进行肽翻译的步骤，可以高效地合成含有氨基酸的肽。
• OXOAZETIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND USE THEREON IN HUMAN MEDICINE AND IN COSMETICS
  申请人：Bouix-Peter Claire

  公开号：US20110274638A1

  公开（公告）日：2011-11-10

  Compounds derived from oxoazetidine corresponding to general formula (I) compositions containing same, processes for their preparation and their use in pharmaceutical or cosmetic compositions are described.

  本文描述了从氧杂环丙酮衍生的化合物，其对应于一般式（I），包含它们的组合物，制备它们的方法以及它们在制药或化妆品组合物中的用途。
• MELANOCORTIN RECEPTOR MODULATORS, PROCESS FOR PREPARING THEM AND USE THERE IN HUMAN MEDICINE AND COSMETICS
  申请人：Bouix-Peter Claire

  公开号：US20110275657A1

  公开（公告）日：2011-11-10

  Melanocortin receptor modulators, processes for preparing them and use thereof in human medicine and cosmetics are described. Melanocortin receptor modulators corresponding to formula (I): compositions containing them, processes for their preparation and their use in pharmaceutical or cosmetic compositions are also described.

  本文描述了黑色素皮质素受体调节剂的制备过程以及它们在人类医学和化妆品中的应用。描述了对应于式（I）的黑色素皮质素受体调节剂，以及包含它们的组合物、其制备过程以及它们在制药或化妆品组合物中的应用。
• MELANOCORTIN RECEPTOR ANTAGONIST COMPOUNDS, PROCESS FOR PREPARING THEM AND USE THEREOF IN HUMAN MEDICINE AND COSMETICS
  申请人：Bouix-Peter Claire

  公开号：US20110281913A1

  公开（公告）日：2011-11-17

  Melanocortin receptor antagonist compounds, processes for preparing them and uses thereof in human medicine and cosmetics are described. Melanocortin receptor antagonist compounds corresponding to the general formula (I): compositions containing them, and processes for their preparation and their use in pharmaceutical or cosmetic compositions are also described.

  本文描述了黑素皮质素受体拮抗剂化合物的制备过程及其在人类医学和化妆品中的用途。该文中的黑素皮质素受体拮抗剂化合物符合一般式(I)：还描述了含有它们的组成物，以及制备它们和在药物或化妆品组合物中使用它们的过程。
• PEPTIDE-COMPOUND CYCLIZATION METHOD
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：US20150080549A1

  公开（公告）日：2015-03-19

  An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

  本发明的目的是提供一种发现对于难以处理的靶点有效的药物的方法，这些药物通常很难被发现。本发明涉及新型的环化肽化合物的方法，以及包含这些化合物的新型肽库，以实现上述目的。