2-tert-Butyl-4-chloro-5-(5-phenyl-[1,3,4]oxadiazol-2-ylmethoxy)-2H-pyridazin-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-tert-Butyl-4-chloro-5-(5-phenyl-[1,3,4]oxadiazol-2-ylmethoxy)-2H-pyridazin-3-one
• 英文别名: 2-Tert-butyl-4-chloro-5-[(5-phenyl-1,3,4-oxadiazol-2-yl)methoxy]pyridazin-3-one
• 化学式: C₁₇H₁₇ClN₄O₃
• 分子量: 360.8
• InChiKey: WIUBAWPIVCLZHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  80.8
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N'-(2-氯乙酰基)苯甲酰肼 在 四丁基溴化铵 、 potassium carbonate 、 三氯氧磷 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.5h， 生成 2-tert-Butyl-4-chloro-5-(5-phenyl-[1,3,4]oxadiazol-2-ylmethoxy)-2H-pyridazin-3-one
  参考文献：
  名称：

  Synthesis and Antifeedant Activity of New Oxadiazolyl 3(2H)-Pyridazinones

  摘要：

  A total of 20 new compounds containing the oxadiazolyl 3(2H)-pyridazinone moiety were synthesized. The structures of all the compounds were confirmed by H-1 NMR, IR, MS, and elemental analysis. Their insect antifeedant activities against Asiatic corn borer Ostrinia furnacalis (Guenee) were examined and compared with commercial azadirachtin. The compounds exhibited significant levels of activity. The feeding deterrency values of IIIa,j were 57% and 51% at 500 mg/kg concentration, respectively.

  DOI：

  10.1021/jf0208029

文献信息

• Synthesis and Antifeedant Activity of New Oxadiazolyl 3(2<i>H</i>)-Pyridazinones
  作者：Song Cao、Xuhong Qian、Gonghua Song、Bing Chai、Zhisheng Jiang

  DOI：10.1021/jf0208029

  日期：2003.1.1

  A total of 20 new compounds containing the oxadiazolyl 3(2H)-pyridazinone moiety were synthesized. The structures of all the compounds were confirmed by H-1 NMR, IR, MS, and elemental analysis. Their insect antifeedant activities against Asiatic corn borer Ostrinia furnacalis (Guenee) were examined and compared with commercial azadirachtin. The compounds exhibited significant levels of activity. The feeding deterrency values of IIIa,j were 57% and 51% at 500 mg/kg concentration, respectively.