2-Tetradecyloxy-phenol | 130442-08-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-Tetradecyloxy-phenol
• 英文别名: 2-tetradecyloxyphenol；2-Tetradecoxyphenol
• CAS: 130442-08-9
• 化学式: C₂₀H₃₄O₂
• 分子量: 306.489
• InChiKey: WOQNPOAPKYFGMB-UHFFFAOYSA-N

物化性质

• 沸点：
  412.5±18.0 °C(Predicted)
• 密度：
  0.938±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  22
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Tetradecyloxy-phenol 在 sodium acetate 、 三乙胺 作用下， 以 四氢呋喃 、 四氯化碳 为溶剂， 反应 7.5h， 生成 3-(Bromomethyl)phenyl 2-(tetradecyloxy) phenyl phosphate
  参考文献：
  名称：

  Analogs of platelet activating factor. 6. Mono- and bis-aryl phosphate antagonists of platelet activating factor

  摘要：

  A series of aryl phosphoglyceride (3, 19-6 1) and bis-aryl phosphate (67-135) antagonists of platelet activating factor (PAF) were prepared. A group of four bifunctional phosphorus reagents (5a-c and 7) were developed that allowed the preparation of these aryl phosphates in which the position of aromatic substitution can be varied. These compounds were examined for their ability to inhibit PAF-induced platelet aggregation of rabbit platelets. Selected compounds were also evaluated for their ability to displace [H-3]PAF from its receptor on rabbit platelets. These in vitro data were compared to similar data obtained for a number of known PAF antagonists. The compounds were evaluated in vivo, in both the mouse and rabbit, for their ability to prevent death induced by a lethal challenge of PAF. The relationships between the biological activity and the nature, lipophilicity, and position of substituents of the aromatic rings were studied. Compound 105 (CL 184005) has been selected to undergo further development as a potential therapeutic agent for the treatment of septic shock in man.

  DOI：

  10.1021/jm00087a023
• 作为产物：
  描述：

  溴代十四烷 、 邻苯二酚 在 盐酸 、 sodium iodide 作用下， 以 四氢呋喃 、 正己烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-Tetradecyloxy-phenol
  参考文献：
  名称：

  Bis-arylphosphate ester antagonists of platelet activating factor

  摘要：

  这项发明是一种新型化合物，化学式为：##STR1##，它们是血小板活化因子的拮抗剂。

  公开号：

  US04983592A1

文献信息

• [EN] A PROCESS FOR THE PREPARATION OF UV ABSORBERS<br/>[FR] PROCÉDÉ DE PRÉPARATION D'ABSORBEURS UV
  申请人：BASF SE

  公开号：WO2020144094A1

  公开（公告）日：2020-07-16

  The presently claimed invention relates to a novel, highly efficient and general process for the preparation of UV absorbers.

  目前所声称的发明涉及一种新颖、高效和通用的紫外线吸收剂制备过程。
• [EN] A PROCESS FOR THE PREPARATION OF TRIAZINE INTERMEDIATES AND A PROCESS FOR THE PREPARATION OF UV ABSORBERS THEREOF<br/>[FR] PROCÉDÉ DE PRÉPARATION D'INTERMÉDIAIRES DE TRIAZINE ET PROCÉDÉ DE PRÉPARATION D'ABSORBEURS UV ASSOCIÉS
  申请人：BASF SE

  公开号：WO2020144093A1

  公开（公告）日：2020-07-16

  The presently claimed invention relates to a novel, highly efficient and general process for the preparation of the triazine intermediates and their use in the preparation of UV absorbers.

  目前所声称的发明涉及一种新颖、高效和通用的三嗪中间体制备过程及其在制备紫外线吸收剂中的应用。
• Novel bis-arylphosphate ester antagonists of platelet activating factor
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0374513A2

  公开（公告）日：1990-06-27

  The invention is novel compounds of the formula: which are antagonists of platelet activating factor.

  本发明是式中的新型化合物： 是血小板活化因子的拮抗剂。
• Polycarbonate resin and optical article used the same
  申请人：Mitsubishi Gas Chemical Company, Inc.

  公开号：EP1138714A2

  公开（公告）日：2001-10-04

  A polycarbonate resin obtained by reaction of (A) a bisphenol compound having a fluorene structure, (B) a bisphenol compound having a polysiloxane structure, (C) other specific bisphenol compound and a carbonic acid ester-forming compound, wherein an amount of (A) bisphenol compound is 30 to 80 % by weight to total amount of (A) bisphenol compound and (B) bisphenol compound,and an amount of (C) bisphenol compound is 1 to 80 % by weight to total amount of (A) bisphenol compound, (B) bisphenol. compound and (C) bisphenol compound,and an intrinsic viscosity of said polycarbonate resin is 0.2 to 1.0 dl/g.

  一种聚碳酸酯树脂，由(A)具有芴结构的双酚化合物、(B)具有聚硅氧烷结构的双酚化合物、(C)其他特定双酚化合物和碳酸酯形成化合物反应而得、其中(A)双酚化合物的用量占(A)双酚化合物和(B)双酚化合物总量的重量比为 30%至 80%，(C)双酚化合物的用量占(A)双酚化合物、(B)双酚化合物和(C)双酚化合物总量的重量比为 1%至 80%。所述聚碳酸酯树脂的固有粘度为 0.2 至 1.0 分升/克。
• MATERIAL FOR CONTACT LENS
  申请人：Menicon Co., Ltd.

  公开号：EP2455797A1

  公开（公告）日：2012-05-23

  According to the present invention, a contact lens material being excellent in oxygen permeability and transparency, being capable of undergoing injection molding, having no water content and having flexibility is provided. The present invention also relates to a contact lens gel material having excellent oxygen permeability and transparency. Particularly, the present invention relates to a contact lens material comprising a polycarbonate resin derived from a compound represented by a general formula (A), a compound represented by a general formula (B) and a compound forming a carbonic acid ester.

  根据本发明，提供了一种透氧性和透明度极佳、可注塑成型、不含水分且具有柔韧性的隐形眼镜材料。本发明还涉及一种具有优异透氧性和透明度的隐形眼镜凝胶材料。特别是，本发明涉及一种隐形眼镜材料，它包含一种聚碳酸酯树脂，由通式（A）代表的化合物、通式（B）代表的化合物和形成碳酸酯的化合物衍生而成。