4-甲基-2-氧代-2H-苯并吡喃-3-甲酸 | 833-31-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 中文名称: 4-甲基-2-氧代-2H-苯并吡喃-3-甲酸
• 英文名称: 4-methyl-2-oxo-2H-chromene-3-carboxylic acid
• 英文别名: 4-methylcoumarin-3-carboxylic acid；4-methyl-2-oxo-2H-chromene-3-carboxylic acid；4-Methyl-2-oxo-2H-chromen-3-carbonsaeure；4-methyl-2-oxo-2H-1-benzopyran-3-carboxylic acid；4-Methyl-cumarin-3-carbonsaeure；4-methyl-2-oxochromene-3-carboxylic acid
• CAS: 833-31-8
• 化学式: C₁₁H₈O₄
• mdl: MFCD06208395
• 分子量: 204.182
• InChiKey: PZHSARNBSOWZHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-甲基-2-氧代-2H-苯并吡喃-3-甲酸 在 五氯化磷 、 苯 作用下， 生成 ethyl 4-methyl-2-oxo-2H-chromene-3-carboxylate
  参考文献：
  名称：

  The Synthesis of Some 3-Substituted-4-methylcoumarins¹

  摘要：

  DOI：

  10.1021/ja01104a032
• 作为产物：
  描述：

  3-氰基-4-甲基香豆素 在 吡啶 、 sodium hydroxide 作用下， 生成 4-甲基-2-氧代-2H-苯并吡喃-3-甲酸
  参考文献：
  名称：

  The Synthesis of Some 3-Substituted-4-methylcoumarins¹

  摘要：

  DOI：

  10.1021/ja01104a032

文献信息

• COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS
  申请人：Chodorowski-Kimmes Sandrine

  公开号：US20100239509A1

  公开（公告）日：2010-09-23

  The present patent application relates to a cosmetic or dermatological composition comprising, in a cosmetically or dermatologically acceptable medium, a polymer comprising: (a) a polymer backbone that may be obtained by reaction: of a polyol comprising 3 to 6 hydroxyl groups; of a monocarboxylic acid containing 6 to 32 carbon atoms; of a polycarboxylic acid comprising at least two carboxylic groups COOH, and/or of a cyclic anhydride such as a polycarboxylic acid and/or of a lactone comprising at least one carboxylic group COOH; and (b) at least one junction group linked to the said polymer backbone and capable of establishing H bonds with one or more partner junction groups, each pairing of a junction group involving at least three H (hydrogen) bonds. The patent application also concerns a cosmetic treatment process using the said composition.

  本专利申请涉及一种化妆品或皮肤科学组合物，包括在化妆品或皮肤科学上可接受的介质中，包含以下聚合物的组合物：(a) 由以下反应得到的聚合物骨架：含有3至6个羟基的多元醇；含有6至32个碳原子的一元羧酸；至少含有两个羧基COOH的多元羧酸，和/或类似多元羧酸的环酐和/或至少含有一个羧基COOH的内酯；以及(b) 至少一个连接到所述聚合物骨架的连接基团，并能够与一个或多个配对连接基团建立H键，每个连接基团的配对涉及至少三个H（氢）键。该专利申请还涉及使用所述组合物的化妆品处理过程。
• COMPOSITION COMPRISING A POLYCONDENSATE, METHOD OF TREATMENT, POLYCONDENSATE, AND METHOD OF PREPARATION
  申请人：GIUSTINIANI Pascal

  公开号：US20090028807A1

  公开（公告）日：2009-01-29

  The present application relates to a cosmetic or pharmaceutical, in particular lipstick, composition comprising a polycondensate The application also relates to a method of cosmetic treatment using the composition, the polycondensate thus defined and a method of preparing the polycondensate.

  本申请涉及一种化妆品或药用品，特别是口红，包括聚缩酸酯的组合物。该申请还涉及一种使用该组合物进行化妆处理的方法，所述聚缩酸酯的定义以及一种制备聚缩酸酯的方法。
• COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT
  申请人：Malle Gerard

  公开号：US20100272660A1

  公开（公告）日：2010-10-28

  The present application relates to a cosmetic or pharmaceutical composition comprising a polycondensate capable of being obtained by the reaction of the following monomers alone: of 10 to 30% by weight, relative to the total weight of the polycondensate, of one or more polyols comprising 3 to 6 hydroxyl groups; of 30 to 80% by weight, relative to the total weight of the polycondensate, of one or more linear, branched and/or cyclic, saturated or unsaturated, non-aromatic monocarboxylic acids comprising 6 to 32 carbon atoms; of 1 to 40% by weight, relative to the total weight of the polycondensate, of one or more polycarboxylic acids and/or cyclic anhydrides of such a polycarboxylic acid and/or lactones comprising at least one COOH group; and optionally of 0.1 to 15% by weight, relative to the total weight of the polycondensate, of one or more silicones having a hydroxyl and/or carboxyl functional group. The application also relates to a method of cosmetic treatment using the said composition, and the polycondensate thus defined.

  本申请涉及一种化妆品或药用组合物，包括由以下单体反应而得的聚缩酸酯：相对于聚缩酸酯的总重量，占10至30%的一种或多种含有3至6个羟基的多元醇；占30至80%的一种或多种线性、支链和/或环状、饱和或不饱和、非芳香族的单羧酸，含有6至32个碳原子；占聚缩酸酯总重量的1至40%的一种或多种多羧酸和/或多羧酸的环状酐和/或含有至少一个COOH基团的内酯；以及可选地占聚缩酸酯总重量的0.1至15%的一种或多种硅氧烷，具有羟基和/或羧基官能团。该申请还涉及使用所述组合物进行化妆处理的方法，以及如此定义的聚缩酸酯。
• Novel reactions of carbon suboxide. IV. Synthesis of some N-Hydroxy-2-oxo-2H-1-benzopyran-3-carboxamides
  作者：Leonardo Bonsignore、Giuseppe Loy、Mario Secci、Salvatore Cabiddu

  DOI：10.1016/s0040-4039(01)99836-3

  日期：1983.1

  Some N-hydroxy-2-oxo-2H-1-benzopyran-3-carboxamides have been prepared by reaction of carbon suboxide with 2-hydroxyaryloximes.

  一些N-羟基-2-氧代-2H-1-苯并吡喃-3-甲酰胺是通过使次氧化碳与2-羟基芳基肟反应制得的。
• A green chemical synthesis of coumarin-3-carboxylic and cinnamic acids using crop-derived products and waste waters as solvents
  作者：Serena Fiorito、Vito Alessandro Taddeo、Salvatore Genovese、Francesco Epifano

  DOI：10.1016/j.tetlet.2016.09.023

  日期：2016.10

  solvents is described. Coumarin-3-carboxylic and cinnamic acids have been synthesized in excellent yields by ultrasound irradiation from differently substituted 2-hydroxybenzaldehydes, 2-hydroxyacetophenones, and benzaldehydes, and Meldrum’s acid as starting substrates. The findings described herein enforce the concept of the usefulness of products and byproducts derived from agriculture and food industry

  近年来，诸如可食用的水果和蔬菜中的果汁以及来自农业和工业加工的废水之类的作物衍生产品已被有效利用，以有效促进多种“经典”和创新的合成有机反应。这种绿色化学方法可以避免使用有毒，污染和有害的材料，同时可以提高农作物产品和工业副产品的商业价值。香豆素-3-羧酸和肉桂酸代表具有有趣和有希望的药理活性的天然和半合成化合物。在这封信中，一种新的，经过改进的方法，用于进行Knoevenagel缩合反应，使用可食用水果和蔬菜（柠檬，葡萄柚，胡萝卜，石榴，猕猴桃，醋，番茄）的汁液生产标题化合物，描述了利口酒（柠檬酒）和废水（酪乳和橄榄加工的残渣）作为溶剂。香豆素-3-羧酸和肉桂酸是通过超声辐照由不同取代的2-羟基苯甲醛，2-羟基苯乙酮和苯甲醛以及Meldrum酸作为起始底物以优异的产率合成的。本文描述的发现加强了源自农业和食品工业的产品和副产品对完成绿色化学过程的有用性的概念。以Meldrum酸为起始底物