2-<2-(2-ethoxyethoxy)ethoxy>-1-fluorobenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-<2-(2-ethoxyethoxy)ethoxy>-1-fluorobenzene
• 英文别名: 1-[2-(2-Ethoxyethoxy)ethoxy]-2-fluorobenzene
• 化学式: C₁₂H₁₇FO₃
• 分子量: 228.264
• InChiKey: XWVFMPHJQXFKCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氯乙氧基-2-乙氧基二乙醇 、 2-氟苯酚 在 resin-bound-Se-B(OEt)3(-)*Na(+) 、 N-甲基吗啉 、 diisopropyl (E)-azodicarboxylate 、 三苯基膦 、 偶氮二异丁腈 、 (Me₃Si)SiH 作用下， 以 乙醇 、 甲苯 为溶剂， 反应 32.0h， 生成 2-<2-(2-ethoxyethoxy)ethoxy>-1-fluorobenzene
  参考文献：
  名称：

  Green Traceless Cleavage from Resin-Bound Selenium and Tellurium and Analysis by 2D²⁹Si/¹H HR-MAS NMR Spectroscopy

  摘要：

  一种用于从树脂结合的硒和碲中无痕迹切割的新型协议被描述。先前作为通过均裂反应从这些树脂中切割的试剂而使用的毒性较高的三丁基锡氢化物已被替换为毒性较低的三(三甲基硅基)硅烷和三(三甲基硅基)锗烷。此外，通过使用高分辨率魔角旋转(HR-MAS)二维29Si/1H核磁共振光谱法对剩余的树脂结合的亚硒硅烷和锗烷残基进行了表征。

  DOI：

  10.1055/s-2005-865311

文献信息

• Traceless Solid Phase Synthesis with Polystyrene-Bound Tellurium and in Comparison with Polystyrene-Bound Selenium
  作者：Thomas Ruhland、Jakob Torang、Henrik Pedersen、Jens Christian Madsen、Kia Svane Bang

  DOI：10.1055/s-2004-831202

  日期：——

  A novel traceless linking strategy by use of polystyrene-bound tellurium is described. The application of the tellurium linker is demonstrated by the solid phase synthesis of a small library of single alkyl aryl ethers containing two points of diversity. Polystyrene-bound tellurium and polystyrene-bound selenium are compared by their cleavage performance under radical conditions (homolysis) at different

  描述了一种使用聚苯乙烯结合碲的新型无痕连接策略。碲接头的应用通过固相合成一个包含两个多样性点的单个烷基芳基醚的小型文库来证明。聚苯乙烯结合的碲和聚苯乙烯结合的硒通过它们在不同温度下的自由基条件（均裂）下的裂解性能进行比较。此外，通过使用高分辨率魔角旋转 (HR-MAS) 核磁共振光谱分析了聚苯乙烯结合的基材。
• Solid support based on selenium useful in solid phase synthesis
  申请人：H. Lundbeck A/S

  公开号：US20040171072A1

  公开（公告）日：2004-09-02

  This invention relates to novel solid support based on selenium and a method for the preparation thereof. The solid support is useful in solid phase synthesis of organic compounds including combinatorial libraries of compounds.

  本发明涉及基于硒的新型固体支持物及其制备方法。该固体支持物可用于有机化合物（包括化合物组合库）的固相合成。
• Selenium-Linking Strategy for Traceless Solid-Phase Synthesis:  Direct Loading, Aliphatic C−H Bond Formation upon Cleavage and Reaction Monitoring by Gradient MAS NMR Spectroscopy
  作者：Thomas Ruhland、Kim Andersen、Henrik Pedersen

  DOI：10.1021/jo9806310

  日期：1998.12.1

  The development of a novel traceless linking strategy for the solid-phase synthesis of small nonpeptide compounds by the use of resin-bound selenium is described. Compounds were attached by direct loading without the requirement of an auxiliary spacer. We demonstrate the synthesis of a small [2 x 3]-sized library of single alkyl aryl ethers with two points of diversity by the Mitsunobu reaction. The selenium-alkyl bond that attaches the alkyl aryl ethers to the resin was smoothly cleaved under radical conditions by homolysis with tributylstannane and catalytic amount of AIBN to generate an aliphatic C-H bond in the liberated ethers. The selenium atom remains immobilized during the entire synthesis, and in the cleavage step, tributylstannyl phenyl selenide is scavenged on the resin. Reaction monitoring was facilitated by the use of gradient high-resolution magic angle spinning 2D-NMR. This new linking method can be applied to solid-phase synthesis of many classes of organic compounds under a broad variation of reaction conditions.
• A SOLID SUPPORT BASED ON SELENIUM USEFUL IN SOLID PHASE SYNTHESIS
  申请人：H. LUNDBECK A/S

  公开号：EP1086153A1

  公开（公告）日：2001-03-28
• [EN] A SOLID SUPPORT BASED ON SELENIUM USEFUL IN SOLID PHASE SYNTHESIS<br/>[FR] SUPPORT SOLIDE BASE SUR DU SELENIUM, UTILE DANS LA SYNTHESE EN PHASE SOLIDE
  申请人：H. LUNDBECK A/S

  公开号：WO1999050317A1

  公开（公告）日：1999-10-07

  (EN) This invention relates to novel solid support based on selenium and a method for the preparation thereof. The solid support is useful in solid phase synthesis of organic compounds including combinatorial libraries of compounds.(FR) L'invention concerne un nouveau support solide basé sur du sélénium et son procédé de préparation. Ledit support solide est utile dans la synthèse en phase solide de composés organiques, dont des banques combinatoires de composés.