(+/-)-2-amino-3-benzyloxycarbonylamino-propionic acid methyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (+/-)-2-amino-3-benzyloxycarbonylamino-propionic acid methyl ester
• 英文别名: (+/-)-2-Amino-3-benzyloxycarbonylamino-propionsaeure-methylester；2-Amino-3-Cbz-amino-propionic acid methyl ester；methyl 2-amino-3-(phenylmethoxycarbonylamino)propanoate
• 化学式: C₁₂H₁₆N₂O₄
• 分子量: 252.27
• InChiKey: NXZYGUGYCBEXAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  90.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (+/-)-2-amino-3-benzyloxycarbonylamino-propionic acid methyl ester 在 2-乙氧基-1-乙氧碳酰基-1,2-二氢喹啉 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  The total synthesis of the antibiotic malonomicin (k16)

  摘要：

  DOI：

  10.1016/s0040-4020(01)93609-9

文献信息

• ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES AS MMP AND TNF INHIBITORS
  申请人：PFIZER INC.

  公开号：EP0821671A1

  公开（公告）日：1998-02-04
• US5861510A
  申请人：——

  公开号：US5861510A

  公开（公告）日：1999-01-19
• US6509337B1
  申请人：——

  公开号：US6509337B1

  公开（公告）日：2003-01-21
• [EN] ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES AS MMP AND TNF INHIBITORS<br/>[FR] DERIVES D'ACIDE HYDROXAMIQUE ARYLSUFONYLE EN TANT QU'INHIBITEURS DE MMP ET DE TNF
  申请人：PFIZER INC.

  公开号：WO1996033172A1

  公开（公告）日：1996-10-24

  (EN) A compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, restenosis, periodontal disease, epidermolysis bullosa, scleritis and other diseases characterized by matrix metalloproteinase activity, as well as AIDS, sepsis, septic shock and other diseases involving the production of TNF.(FR) La présente invention décrit un composé de formule (I) dans laquelle R1, R2, R3, R4, R5, R6, R7, R8, R9 et Ar sont tels que définis dans la description, utilisé dans le traitement de troubles choisis parmi l'arthrite, le cancer, l'ulcération des tissus, la resténose, la parodontopathie, l'épidermolyse bulleuse, la sclérite et d'autres maladies caractérisées par une activité de métalloprotéase matricielle, ainsi que le SIDA, la septicémie, le choc septique et d'autres maladies comprenant la production de TNF.
• [EN] PYRIDINONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF<br/>[FR] DÉRIVÉS DE PYRIDINONE ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：BAYER IP GMBH

  公开号：WO2012175514A1

  公开（公告）日：2012-12-27

  The present application relates to imidazopyridinone derivatives of the formula (I) as gonadotropin-releasing hormone (GnRH) receptor antagonists. Further aspects of the invention are a process for their preparation and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially sex-hormone-related conditions in both men and women. For example, such conditions include endometriosis, uterine fibroids, polycystic ovarian disease, hirsutism, precocious puberty, gonadal steroid-dependent neoplasia such as cancers of the prostate, breast and ovary, gonadotrope pituitary adenomas, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hypertrophy, contraception and infertility (e.g., assisted reproductive therapy such as in vitro fertilization).