tert-butyl N-[2-(methylideneamino)ethyl]carbamate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl N-[2-(methylideneamino)ethyl]carbamate
• 化学式: C₈H₁₆N₂O₂
• 分子量: 172.227
• InChiKey: NEEPZWQUHAZHEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[2-(methylideneamino)ethyl]carbamate 、 次氮基三乙酸 、 tris(2-isocyanoethyl)amine 以 甲醇 为溶剂， 反应 0.5h， 生成 tert-butyl N-[2-[16,21-bis[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]-3,6,14,17,20,23-hexaoxo-1,4,7,10,13,16,21,24-octazabicyclo[8.8.8]hexacosan-4-yl]ethyl]carbamate
  参考文献：
  名称：

  Supramolecular Compounds from Multiple Ugi Multicomponent Macrocyclizations:  Peptoid-based Cryptands, Cages, and Cryptophanes

  摘要：

  The first 3-fold multicomponent macrocyclizations of trifunctional building blocks were developed to produce, in one pot, cryptands, cages, and cryptophanes with peptoid tethers carrying additional recognition motifs. The straightforward, efficient, and diversity-oriented fashion by which these complex macromulticycles are obtained is suitable for building combinatorial libraries of synthetic receptors with potential applicability in catalysis and supramolecular and coordination chemistry. The strategy also easily allows creation of asymmetric macromulticyclic cavities, with up to 20 new bonds formed in one pot.

  DOI：

  10.1021/ja060720r
• 作为产物：
  描述：

  聚合甲醛 、 N-叔丁氧羰基-1,2-乙二胺 以 甲醇 为溶剂， 反应 1.0h， 生成 tert-butyl N-[2-(methylideneamino)ethyl]carbamate
  参考文献：
  名称：

  Supramolecular Compounds from Multiple Ugi Multicomponent Macrocyclizations:  Peptoid-based Cryptands, Cages, and Cryptophanes

  摘要：

  The first 3-fold multicomponent macrocyclizations of trifunctional building blocks were developed to produce, in one pot, cryptands, cages, and cryptophanes with peptoid tethers carrying additional recognition motifs. The straightforward, efficient, and diversity-oriented fashion by which these complex macromulticycles are obtained is suitable for building combinatorial libraries of synthetic receptors with potential applicability in catalysis and supramolecular and coordination chemistry. The strategy also easily allows creation of asymmetric macromulticyclic cavities, with up to 20 new bonds formed in one pot.

  DOI：

  10.1021/ja060720r

文献信息

• Imidazolyl derivatives
  申请人：Thurieau Alain Christophe

  公开号：US20070299073A1

  公开（公告）日：2007-12-27

  The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonist or antagonists of somatostatin receptors.

  本发明涉及式（I）的咪唑基衍生物，其中取代基在说明书中定义，它们可用作生长抑素受体的激动剂或拮抗剂。
• FATTY ACID ACETYLATED SALICYLATES AND THEIR USES
  申请人：Catabasis Pharmaceuticals, Inc.

  公开号：US20140221323A1

  公开（公告）日：2014-08-07

  The invention relates to Fatty Acid Acetylated Salicylate Derivatives; compositions comprising an effective amount of a Fatty Acid Acetylated Salicylate Derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a Fatty Acid Acetylated Salicylate Derivative.

  本发明涉及脂肪酸乙酰化水杨酸衍生物，包括含有效量的脂肪酸乙酰化水杨酸衍生物的组合物，以及治疗或预防炎症性疾病的方法，包括给予有效量的脂肪酸乙酰化水杨酸衍生物。
• SUBSTITUTED TRIAZOLE BORONIC ACID COMPOUNDS
  申请人：HOFFMANN-LA ROCHE INC.

  公开号：US20150329565A1

  公开（公告）日：2015-11-19

  The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are LMP7 inhibitors and may be useful in treating associated inflammatory diseases and disorders such as, for example, rheumatoid arthritis, lupus and irritable bowel disease.

  本发明涉及化合物式(I)及其药学上可接受的盐。此外，本发明还涉及制造和使用化合物I的方法，以及含有这些化合物的药物组合物。化合物I是LMP7抑制剂，可用于治疗相关的炎症性疾病和疾病，例如类风湿性关节炎、狼疮和肠易激综合征。
• US7566734B2
  申请人：——

  公开号：US7566734B2

  公开（公告）日：2009-07-28
• US7638546B1
  申请人：——

  公开号：US7638546B1

  公开（公告）日：2009-12-29