4-[(4-戊基苯基)乙炔基]苯甲腈 | 56982-41-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-[(4-戊基苯基)乙炔基]苯甲腈
• 英文名称: 4-((4-pentylphenyl)ethynyl)benzonitrile
• 英文别名: 4-[(4-Pentylphenyl)ethynyl]benzonitrile；4-[2-(4-pentylphenyl)ethynyl]benzonitrile
• CAS: 56982-41-3
• 化学式: C₂₀H₁₉N
• 分子量: 273.378
• InChiKey: FXQIMFIGGHKPGL-UHFFFAOYSA-N

物化性质

• 沸点：
  427.6±38.0 °C(Predicted)
• 密度：
  1.06±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-溴苯腈 、 4-戊基苯乙炔 在 9-噻吨酮 、 N-叔丁基异丙醇胺 、 nickel(II) acetate tetrahydrate 、 zinc trifluoromethanesulfonate 、 4,4'-二叔丁基-2,2'-二吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以87%的产率得到4-[(4-戊基苯基)乙炔基]苯甲腈
  参考文献：
  名称：

  通过可见光敏化镍催化的Sonogashira C（sp）-C（sp2）耦合。

  摘要：

  通过能量转移模式已经开发出一种有效的方法，用于可见光引发的镍催化的Sonogashira C（sp）–C（sp 2）耦合。噻吨酮-9-一作为光敏剂可以以高产率显着促进炔烃与各种（杂）芳基卤化物的芳基化。交叉偶联反应经历了将芳基卤化物逐步氧化添加到镍（0）上，将所得的芳基–镍（II）卤化物与乙酰化锌（II）过渡金属化为芳基–镍（II）乙酰化物，能量从噻吨酮9-1的激发态变成芳基– Ni（II）乙炔化物，并还原消除为芳基炔烃。

  DOI：

  10.1021/acs.joc.0c01177

文献信息

• Dispersion Liquid Comprising Liquid Crystal-Compatible Particles, Paste Obtained Therefrom, and Mehtod for Preparing the Same
  申请人：Nishino Shigeyoshi

  公开号：US20100224826A1

  公开（公告）日：2010-09-09

  A task of the present invention is to provide a method for preparing a dispersion liquid comprising liquid crystal-compatible particles and a paste thereof, which is commercially advantageous in that a dispersion liquid comprising liquid crystal-compatible particles and a uniform liquid crystal-compatible particle paste can be obtained using a method which can easily achieve mass-production. The task of the present invention is achieved by a method for preparing a dispersion liquid comprising liquid crystal-compatible particles wherein the method comprises mixing together at least one type of liquid crystal molecules, a secondary alcohol represented by the following general formula (1): wherein R 1 and R 2 are the same or different and independently represent a hydrocarbon group optionally having a substituent, or R 1 and R 2 may be bonded together to form a ring, and an organic solvent, and adding to the resultant mixture a solution containing at least one type of metal ions while heating the mixture under reflux to effect a reaction.
• US9175220B2
  申请人：——

  公开号：US9175220B2

  公开（公告）日：2015-11-03
• Nickel-Catalyzed Sonogashira C(sp)–C(sp²) Coupling through Visible-Light Sensitization
  作者：Da-Liang Zhu、Ruijie Xu、Qi Wu、Hai-Yan Li、Jian-Ping Lang、Hong-Xi Li

  DOI：10.1021/acs.joc.0c01177

  日期：2020.7.17

  efficient method for visible-light-initiated, nickel-catalyzed Sonogashira C(sp)–C(sp2) coupling has been developed via an energy-transfer mode. Thioxanthen-9-one as a photosensitizer could significantly accelerate the arylation of alkynes with a wide range of (hetero)aryl halides in high yields. The cross-coupling reaction undergoes the stepwise oxidative addition of an arylhalide to nickel(0), transmetalation

  通过能量转移模式已经开发出一种有效的方法，用于可见光引发的镍催化的Sonogashira C（sp）–C（sp 2）耦合。噻吨酮-9-一作为光敏剂可以以高产率显着促进炔烃与各种（杂）芳基卤化物的芳基化。交叉偶联反应经历了将芳基卤化物逐步氧化添加到镍（0）上，将所得的芳基–镍（II）卤化物与乙酰化锌（II）过渡金属化为芳基–镍（II）乙酰化物，能量从噻吨酮9-1的激发态变成芳基– Ni（II）乙炔化物，并还原消除为芳基炔烃。