4,6(1H,5H)-嘧啶二酮(7CI,9CI) | 25286-58-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 4,6(1H,5H)-嘧啶二酮(7CI,9CI)
• 英文名称: 1H-pyrimidine-4,6-dione
• 英文别名: 1H-Pyrimidin-4,6-dion；4,6-dihydroxypyrimidine；1,4,5,6-Tetrahydro-4,6-dioxopyrimidin；4,6-Dioxo-pyrimidin；4,6(1H,5H)-Pyrimidinedione；1H-pyrimidine-4,6-dione
• CAS: 25286-58-2
• 化学式: C₄H₄N₂O₂
• mdl: MFCD00955571
• 分子量: 112.088
• InChiKey: HFAYWAUCHUMJMH-UHFFFAOYSA-N

物化性质

• 密度：
  1.55±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  58.5
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933599090

反应信息

• 作为反应物：
  描述：

  4,6(1H,5H)-嘧啶二酮(7CI,9CI) 在 N,N-二甲基苯胺 、 三氯氧磷 作用下， 生成 4,6-二氯嘧啶
  参考文献：
  名称：

  Kenner et al., Journal of the Chemical Society, 1943, p. 574

  摘要：

  DOI：
• 作为产物：
  描述：

  丙二酸二乙酯 、 甲脒 在 乙醇 、 sodium ethanolate 作用下， 生成 4,6(1H,5H)-嘧啶二酮(7CI,9CI)
  参考文献：
  名称：

  Kenner et al., Journal of the Chemical Society, 1943, p. 388

  摘要：

  DOI：

文献信息

• Inhibitory effect of metalloporphyrins in conjunction with cholesterol on hepatic phospholipase A2 activityin vivo in rats
  作者：Ramesh Chandra、Manisha Tiwari、Ritu Aneja、Sujata K. Dass、Archana Sharma

  DOI：10.1007/bf02883744

  日期：2000.7

  We investigated the effect of cholesterol and the metalloporphyrins cobalt mesoporphyrin (CoMP) and chromium protoporphyrin (CrPP) on phospholipase A(2) (PLA(2)) activity and the consequent hepatic mitochondrial stability as well as on lipid concentrations. Our studies revealed that on administration of cholesterol, CrPP, CoMP as well as simultaneous adminstration of cholesterol and CrPP, there was an inhibition of PLA(2) activity. These moieties may therefore, be agents for preventing destabilisation of the mitochondrial membrane and the consequent pathological conditions which may arise due to membrane lysis. Our results revealed that cholesterol administration increased phospholipid concentration, albeit by modest amounts. Although the independent administration of metalloporphyrins led only to minor elevations in phospholipid concentration, the simultaneous administration of cholesterol and CrPP generated a steep elevation in the concentration of total phospholipid. Since cholesterol inhibits PLA(2) activity it has the potential of being therapeutic agent for preventing the pathological conditions which may arise due to membrane lysis.
• Kenner et al., Journal of the Chemical Society, 1943, p. 574
  作者：Kenner et al.

  DOI：——

  日期：——
• Boon et al., Journal of the Chemical Society, 1951, p. 96,99
  作者：Boon et al.

  DOI：——

  日期：——
• Hull, Journal of the Chemical Society, 1951, p. 2214
  作者：Hull

  DOI：——

  日期：——
• Chesterfield et al., Journal of the Chemical Society, 1955, p. 3478,3481
  作者：Chesterfield et al.

  DOI：——

  日期：——