(E)-(4-chlorostyryl)(4-methoxybenzyl)sulfane | 908344-13-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (E)-(4-chlorostyryl)(4-methoxybenzyl)sulfane
• 英文别名: 1-chloro-4-[(E)-2-[(4-methoxyphenyl)methylsulfanyl]ethenyl]benzene
• CAS: 908344-13-8
• 化学式: C₁₆H₁₅ClOS
• 分子量: 290.813
• InChiKey: LMRFNSAHILVXIA-ZHACJKMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  34.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对氯苯丙炔酸 、 4-甲氧基苄硫醇 在 copper(l) iodide 、 caesium carbonate 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 24.0h， 生成 (Z)-(4-chlorostyryl)(4-methoxybenzyl)sulfane 、 (E)-(4-chlorostyryl)(4-methoxybenzyl)sulfane
  参考文献：
  名称：

  Synthesis of Vinyl Sulfides by Copper-Catalyzed Decarboxylative C−S Cross-Coupling

  摘要：

  A novel method for the synthesis of vinyl sulfides by the decarboxylative cross-coupling of arylpropiolic acids with thiols using copper(I) salts as catalysts has been developed. In the presence of Cul and Cs2CO3, a variety of thiols reacted with arylpropiolic acids to afford the corresponding vinyl sulfides in good to excellent yields with high stereoselectivity for Z-isomers.

  DOI：

  10.1021/ol101729k

文献信息

• Unsaturated Sulfides, Sulfones, Sulfoxides and Sulfonamides Synthesis
  申请人：Reddy M.V. Ramana

  公开号：US20090124828A1

  公开（公告）日：2009-05-14

  α,β-Unsaturated sulfides, sulfones, sulfoxides and sulfonamides according to Formula I: wherein Ar 1 , Ar 2 , X, n, * and R are as defined herein, are prepared by dehydration of β-hydroxy sulfides, sulfones, sulfoxides or sulfonamides.

  根据公式I，制备α，β-不饱和硫化物，磺酰酸，亚磺酸和磺酰胺，其中Ar1，Ar2，X，n，*和R的定义如下，通过β-羟基硫化物，磺酰酸，亚磺酸或磺酰胺的脱水反应制备。
• UNSATURATED SULFIDES, SULFONES, SULFOXIDES AND SULFONAMIDES SYNTHESIS
  申请人：Temple University - Of The Commonwealth System of Higher Education

  公开号：EP1896401B1

  公开（公告）日：2013-04-10
• US8143453B2
  申请人：——

  公开号：US8143453B2

  公开（公告）日：2012-03-27
• Synthesis of Vinyl Sulfides by Copper-Catalyzed Decarboxylative C−S Cross-Coupling
  作者：Sadananda Ranjit、Zhongyu Duan、Pengfei Zhang、Xiaogang Liu

  DOI：10.1021/ol101729k

  日期：2010.9.17

  A novel method for the synthesis of vinyl sulfides by the decarboxylative cross-coupling of arylpropiolic acids with thiols using copper(I) salts as catalysts has been developed. In the presence of Cul and Cs2CO3, a variety of thiols reacted with arylpropiolic acids to afford the corresponding vinyl sulfides in good to excellent yields with high stereoselectivity for Z-isomers.