Room Temperature, Palladium-Mediated <i>P</i>–Arylation of Secondary Phosphine Oxides
作者:Aaron J. Bloomfield、Seth B. Herzon
DOI:10.1021/ol301831k
日期:2012.9.7
iodides are efficiently coupled with secondary phosphine oxides using 1 mol % of a catalyst formed in situ from tris(dibenzylideneacetone)dipalladium and Xantphos (1). Scalemic (S)-methylphenylphosphine oxide [(S)-2e] is shown to undergo arylation without detectable stereoerosion. The application of this method to the synthesis of novel P-chiralphosphines and PCP ligands is demonstrated.
Electron-Transfer Nucleophilic Substitution Reactions on Neopentyl- and Phenyl-Substituted Alkyl Chlorides. Effect of the Bridge Length on the Intramolecular Electron-Transfer Catalysis
作者:José S. Duca、Mariana H. Gallego、Adriana B. Pierini、Roberto A. Rossi
DOI:10.1021/jo980657r
日期:1999.4.1
substitution reaction of the chlorides RMe(2)CCH(2)Cl (R = Me, 4; Ph, 5a; PhCH(2), 5b) and their relative reactivities toward diphenyl phosphide ions were studied under irradiation in liquid ammonia. The relative reactivities determined were k(5a)()/k(4)() congruent with 9 and k(5b)()/k(4)() congruent with 0.85. These reactions are proposed to occur through the S(RN)1 mechanism. The higher reactivity of 5a
Atropisomers and Methods of Altering Enantiomeric Excess
申请人:Florida State University Research Foundation, Inc.
公开号:US20180179120A1
公开(公告)日:2018-06-28
Provided herein are methods of altering enantiomeric excess. The methods may include irradiating an atropisomer that includes at least one chiral substituent to alter the enantiomeric excess of the atropisomer. The at least one chiral substituent may be removed following irradiation.
Copper-Catalyzed Cross-Coupling of Alkyl and Phosphorus Radicals for C(sp<sup>3</sup>)–P Bond Formation
作者:Cheng-Kun Li、Ze-Kun Tao、Adedamola Shoberu、Wei Zhang、Jian-Ping Zou
DOI:10.1021/acs.orglett.2c02454
日期:2022.8.19
A CuI-catalyzed cross-coupling of alkyl- and phosphorus-centered radicals for C(sp3)–P bondformation is introduced. Diacyl peroxides, generated in situ from aliphatic acids and H2O2, serve as a source for alkyl radicals and also an initiator for the generation of phosphorus radicals from H–P(O) compounds.
介绍了一种 Cu I催化的以烷基和磷为中心的自由基的交叉偶联,以形成 C(sp 3 )-P 键。由脂肪酸和 H 2 O 2原位生成的二酰基过氧化物可作为烷基自由基的来源,也是从 H-P(O) 化合物生成磷自由基的引发剂。