N-[1-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-glycine | 2441-81-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[1-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-glycine
• 英文别名: N-[1-(N-Benzyloxycarbonyl-glycyl)-L-prolyl]-glycin；Cbz-glycylprolylglycine；2-[[(2S)-1-[2-(phenylmethoxycarbonylamino)acetyl]pyrrolidine-2-carbonyl]amino]acetic acid
• CAS: 2441-81-8
• 化学式: C₁₇H₂₁N₃O₆
• 分子量: 363.37
• InChiKey: OHUANVDWHNPCHQ-ZDUSSCGKSA-N

物化性质

• 熔点：
  135-138 °C
• 沸点：
  720.7±60.0 °C(Predicted)
• 密度：
  1.354±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-[1-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-glycine 在 甲醇 、 钯 、 溶剂黄146 作用下， 生成 甘氨酰-L-脯氨酰-甘氨酸
  参考文献：
  名称：

  Simmonds; Fruton, Journal of Biological Chemistry, 1948, vol. 174, p. 705,713

  摘要：

  DOI：
• 作为产物：
  描述：

  Z-甘氨酸-脯氨酸 在 乙酸乙酯 、 三乙胺 、 氯甲酸异丁酯 作用下， 生成 N-[1-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-glycine
  参考文献：
  名称：

  Davis; Smith, Journal of Biological Chemistry, 1953, vol. 200, p. 373,383

  摘要：

  DOI：

文献信息

• Compositions and methods for producing clostridial collagenases
  申请人：Wegman Thomas L.

  公开号：US10119131B2

  公开（公告）日：2018-11-06

  The present invention provides a method for producing a drug product comprising a combination of highly purified collagenase I and collagenase II from Clostridium histolyticum. The method utilizes an improved medium for the cultivation of Clostridium histolyticum which includes a non-meat-derived (i.e., non-mammalian) peptone or vegetable peptone. The method includes one or more of: (1) reducing glucose content in the meat-free or vegetable-derived media; and (2) increasing the salt concentration in the meat-free or vegetable-derived media. Also provided is a drug product which includes collagenase I and collagenase II at an optimized fixed mass ratio, and which has a purity of greater than at least 95%.

  本发明提供了一种生产药物产品的方法，该产品包含来自组织溶解梭菌的高纯度胶原酶 I 和胶原酶 II 的组合。该方法利用改良的培养基来培养组织溶解梭菌，该培养基包括非肉源（即非哺乳动物）蛋白胨或植物蛋白胨。该方法包括以下一项或多项：(1) 降低无肉培养基或植物培养基中的葡萄糖含量；(2) 提高无肉培养基或植物培养基中的盐浓度。此外，还提供了一种药物产品，其中包括以优化的固定质量比的胶原酶 I 和胶原酶 II，其纯度大于至少 95%。
• 702. Polypeptides. Part IV. The self-condensation of the esters of some peptides of glycine and proline
  作者：H. N. Rydon、P. W. G. Smith

  DOI：10.1039/jr9560003642

  日期：——
• INJECTION TECHNIQUES FOR THE TREATMENT OF CELLULITE
  申请人：Endo Global Aesthetics Limited

  公开号：EP3820437A2

  公开（公告）日：2021-05-19
• COMPOSITIONS AND METHODS FOR TREATING CELLULITE
  申请人：Endo Global Aesthetics Limited

  公开号：EP3852715A1

  公开（公告）日：2021-07-28
• COMPOSITIONS AND METHODS FOR PRODUCING CLOSTRIDIAL COLLAGENASES
  申请人：WEGMAN Thomas L.

  公开号：US20120237497A1

  公开（公告）日：2012-09-20

  The present invention provides a method for producing a drug product comprising a combination of highly purified collagenase I and collagenase II from Clostridium histolyticum . The method utilizes an improved medium for the cultivation of Clostridium histolyticum which includes a non-meat-derived (i.e., non-mammalian) peptone or vegetable peptone. The method includes one or more of: (1) reducing glucose content in the meat-free or vegetable-derived media; and (2) increasing the salt concentration in the meat-free or vegetable-derived media. Also provided is a drug product which includes collagenase I and collagenase II at an optimized fixed mass ratio, and which has a purity of greater than at least 95%.