N,N'-双-(3-(3,5-二叔丁基-4-羟基苯基)丙酰基)己二胺 | 23128-74-7

• 物质功能分类: 催化剂及助剂 - 抗氧剂
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N,N'-双-(3-(3,5-二叔丁基-4-羟基苯基)丙酰基)己二胺
• 中文别名: 抗氧化剂1098；抗氧剂1098；N,N'-六亚甲基双(3,5-二叔丁基-4-羟基苯丙酰胺)；N,N"-双-(3-(3,5-二叔丁基-4-羟基苯基)丙酰基)己二胺；抗氧剂198
• 英文名称: N,N'-bis[β-(3,5-di-tert-butyl-4-hydroxyphenyl)propionyl]hexamethylenediamine
• 英文别名: N,N'-bis-(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionyl)hexamethylenediamine；N,N'-hexamethylene bis(3,5-di-tert-butyl-4-hydroxyhydrocinnamamide)；N,N-hexamethylene bis(3,5-di-t-butyl-4-hydroxyhydrocinnamamide)；Irganox 1098；N,N'-bis(3,5-di-tert-butyl-4-hydroxyphenylpropionyl)hexamethylenediamide；N,N'-bis-(3,5-di-tert.-butyl-4-hydroxyphenylpropionyl)-hexamethylenediamine；Benzenepropanamide, N,N'-1,6-hexanediylbis(3,5-bis(1,1-dimethylethyl)-4-hydroxy-；3-(3,5-ditert-butyl-4-hydroxyphenyl)-N-[6-[3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoylamino]hexyl]propanamide
• CAS: 23128-74-7
• 化学式: C₄₀H₆₄N₂O₄
• mdl: MFCD00134697
• 分子量: 636.959
• InChiKey: OKOBUGCCXMIKDM-UHFFFAOYSA-N

物化性质

• 熔点：
  156-161°C
• 沸点：
  740.1±60.0 °C(Predicted)
• 密度：
  1.021±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）
• LogP：
  9.6 at 25℃
• 物理描述：
  DryPowder; OtherSolid; PelletsLargeCrystals

计算性质

• 辛醇/水分配系数(LogP)：
  10
• 重原子数：
  46
• 可旋转键数：
  17
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  98.7
• 氢给体数：
  4
• 氢受体数：
  4

安全信息

• 海关编码：
  2924299090
• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302

SDS

Material Safety Data Sheet

---

Section 1. Identification of the substance
Product Name: 3,3’-Bis(3,5-di-tert-butyl-4-hydroxyphenyl)-n,n’-hexamethylenedipropionamide
Synonyms:

---

Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

---

Section 3. Composition/information on ingredients.
Ingredient name: 3,3’-Bis(3,5-di-tert-butyl-4-hydroxyphenyl)-n,n’-hexamethylenedipropionamide
CAS number: 23128-74-7

---

Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

---

Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

---

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

---

Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

---

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

---

Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C40H64N2O4
Molecular weight: 637.0

---

Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

---

Section 11. Toxicological information
No data.

---

Section 12. Ecological information
No data.

---

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

---

Section 14. Transportation information
Non-harzardous for air and ground transportation.

---

Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

简介

抗氧剂1098呈白色至类白色粉末状，与材料的相容性好，挥发性低，在老化前后对材料颜色影响小。

物理特性

• 外观：白色结晶粉末
• 透光率：
  • 425nm ≥97%
  • 500nm ≥98%
• 挥发分：≤0.5%
• 灰 分：≤0.1%
• 熔 点：155°C-161°C
• 溶解性：澄清溶液
• 含 量：≥98%

应用

抗氧剂1098是一种不变色、不污染、耐热氧化和耐萃取的高性能通用抗氧剂。它广泛应用于聚酰胺、聚烯烃、聚苯乙烯、ABS树脂、缩醛类树脂、聚氨酯以及橡胶等聚合物中，也可与含磷的辅助抗氧剂配合使用，以提高抗氧化性。

添加量

添加量：0.05%-1.0%，具体添加量需根据客户应用测试确定。

储存

应按一般化学品要求储存在干燥凉爽环境中，建议储存时间为12个月。主要用于聚酰胺、聚烯烃、聚苯乙烯、ABS树脂、缩醛类树脂、聚氨酯以及橡胶等聚合物中。

反应信息

• 作为反应物：
  描述：

  1-(2'-羟乙基)-2,2,6,6-四甲基-4-哌啶醇 、 2,6-二叔丁基-4-甲基苯酚 、 N,N'-双-(3-(3,5-二叔丁基-4-羟基苯基)丙酰基)己二胺 在 氮 、 tetrabutoxytitanium 、 甲醇 、 甲基丙烯酸甲酯 、 crude product 、 SiO2 、 methanol diethyl ether 、 氨 作用下， 以 甲基丙烯酸甲酯 为溶剂， 反应 40.0h， 以to give pure 1-(2-methacryloyloxyethyl)-4-methacryloyloxy-2,2,6,6-tetramethylpiperidine in the form of a colourless oil的产率得到1-(2-methacryloyloxyethyl)-4-methacryloyloxy-2,2,6,6-tetramethylpiperidine
  参考文献：
  名称：

  Unsaturated derivatives of 2,2,6,6-tetramethylpiperidine

  摘要：

  式I的化合物 ##STR1## 其中R为氢、甲基或氰基，而R'为氢、C.sub.1-C.sub.8烷基或苯基，适用于与乙烯基不饱和单体共聚，形成交联共聚物，这些共聚物对光稳定。

  公开号：

  US04942238A1
• 作为产物：
  描述：

  3-(3,5-二叔丁基-4-羟基苯基)丙酸甲酯 在 silica gel 、 sodium hydroxide 作用下， 以 甲醇 、 5,5-dimethyl-1,3-cyclohexadiene 、 水 为溶剂， 反应 12.0h， 生成 N,N'-双-(3-(3,5-二叔丁基-4-羟基苯基)丙酰基)己二胺
  参考文献：
  名称：

  一种抗氧剂的制备方法

  摘要：

  本发明提供了一种抗氧剂的制备方法，该方法包括：将式（III）所示的化合物和式（Ⅳ）所示的化合物在有机溶剂存在下进行脱水反应，其特征在于，在脱水反应的过程中，使反应生成的水和部分有机溶剂从反应体系中分离出，并进行分水处理，然后将经过分水处理的含水有机溶剂与第一脱水剂接触，将接触后得到的有机溶剂返回到反应体系中；其中，n为1或2，x为1或2，y为0‑6的整数，R1和R2不同时为氢原子或碳原子数为1‑6的直链或支链烷基；R3和R4不同时为氢原子或碳原子数为1‑6的直链或支链烷基。采用本发明提供的方法制备抗氧剂，能够有效提高反应体系的脱水效果，从而提高反应效率以及产品收率。

  公开号：

  CN104211616B

文献信息

• [EN] STERICALLY HINDERED AMINE STABILIZERS<br/>[FR] STABILISANTS D'AMINES À ENCOMBREMENT STÉRIQUE
  申请人：BASF SE

  公开号：WO2010142572A1

  公开（公告）日：2010-12-16

  The instant invention pertains to hindered amine compounds having at least two nitrogen atoms with different basicity. One part is substituted on the N-atom by alkoxy moieties and the other part is substituted on the N-atom by a hydroxy-alkyl moiety. These materials are particularly effective in stabilizing polymers, especially thermoplastic polyolefins, against the deleterious effects of oxidative, thermal and actinic radiation. The compounds are also particularly effective in stabilizing acid catalyzed and ambient cured coatings systems.

  这项瞬时发明涉及具有至少两个氮原子且碱度不同的受阻胺化合物。其中一部分在N原子上被烷氧基团取代，另一部分在N原子上被一个羟基-烷基基团取代。这些材料在稳定聚合物方面特别有效，尤其是热塑性聚烯烃，可以抵御氧化、热和光辐射的有害影响。这些化合物在稳定酸催化和环境固化的涂层系统方面也特别有效。
• 4-Formyl amino-n-methylpiperidine derivatives, the use thereof as stabilisers and organic material stabilised therewith
  申请人：——

  公开号：US20030083406A1

  公开（公告）日：2003-05-01

  The present invention relates to 4-formylamino-N-methylpiperidine derivatives of the formula (I) 1 where the variables are as defined in the Description, to a process for preparing these piperidine derivatives, to the use of these piperidine derivatives of the invention, or prepared according to the invention, for stabilizing organic material, in particular for stabilizing plastics or coating materials, and also to the use of these piperidine derivatives of the invention, or prepared according to the invention, as light stabilizers or stabilizers for wood surfaces. The present invention further relates to stabilized organic material which comprises these piperidine derivatives of the invention or prepared according to the invention.

  本发明涉及通式(I)的4-甲酰氨基-N-甲基哌啶衍生物 1 其中变量如说明书中所定义，涉及制备这些哌啶衍生物的方法，涉及这些本发明的哌啶衍生物或按照本发明制备的哌啶衍生物用于稳定有机材料，特别是用于稳定塑料或涂料材料，还涉及这些本发明的哌啶衍生物或按照本发明制备的哌啶衍生物作为光稳定剂或木材表面的稳定剂的使用。 本发明还涉及包含这些本发明的哌啶衍生物或按照本发明制备的哌啶衍生物的稳定有机材料。
• N-Allyl/benzyl substituted phenylenediamine stabilizers
  申请人：CIBA-GEIGY AG

  公开号：EP0538195A2

  公开（公告）日：1993-04-21

  Compositions are described which comprise (a) a lubricant, subject to oxidative or thermal degradation, and (b) at least one compound of formula I wherein    R⁵, R⁶, R⁷ and R⁸ are independently hydrogen, alkenyl of 3 to 18 carbon atoms, aralkyl of 7 to 15 carbon atoms, aryl of 6 to 10 carbon atoms or said aryl substituted by one to three substituents selected from the group consisting of alkyl of 1 to 20 carbon atoms, cycloalkyl of 5 to 12 carbon atoms, aralkyl of 7 to 15 carbon atoms, -CN, -NO⁶, halogen, -ORψ, -NR¼R½, -SR¾, -COOR| and -CONR⁵⁴R⁵⁵ where Rψ, R¼, R½, R¾, R|, R⁵⁴ and R⁵⁵ are independently hydrogen, alkyl of 1 to 20 carbon atoms, alkenyl of 3 to 18 carbon atoms, aryl of 6 to 10 carbon atoms, cycloalkyl of 5 to 12 carbon atoms or aralkyl of 7 to 15 carbon atoms. Some of the compounds of formula one are novel.

  描述了以下组成的组合物： (a) 一种润滑剂，容易受到氧化或热降解，和 (b) 至少一个公式 I 的化合物 其中 R⁵, R⁶, R⁷ 和 R⁸ 分别独立为氢，3至18碳原子的烯基，7至15碳原子的芳基烷基，6至10碳原子的芳基或所述芳基被1至3个选自以下组的取代基所取代：1至20碳原子的烷基，5至12碳原子的环烷基，7至15碳原子的芳基烷基，-CN, -NO⁶, 卤素，-ORψ, -NR¼R½, -SR¾, -COOR| 和 -CONR⁵⁴R⁵⁵，其中 Rψ, R¼, R½, R¾, R|, R⁵⁴ 和 R⁵⁵ 分别独立为氢，1至20碳原子的烷基，3至18碳原子的烯基，6至10碳原子的芳基，5至12碳原子的环烷基或7至15碳原子的芳基烷基。 公式 I 中的某些化合物是新颖的。
• Thioimidazolidine derivatives as light stabilizers for polymers
  申请人：——

  公开号：US20030109609A1

  公开（公告）日：2003-06-12

  A compound of the formula (I) wherein G 1 , G 2 , G 3 and G 4 are independently of one another C 1 -C 18 alkyl or C 5 -C 12 cycloalkyl or the radicals G 1 and G 2 and the radicals G 3 and G 4 form independently of one another, together with the carbon atom they are attached to, C 5 -C 12 cycloalkyl; R is hydrogen, C 1 -C 18 alkyl, oxyl, —OH, —CH 2 CN, C 3 -C 6 alkenyl, C 3 -C 8 alkynyl, C 7 -C 12 phenylalkyl unsubstituted or substituted on the phenyl radical by C 1 -C 4 alkyl and/or C 1 -C 4 alkoxy; C 1 -C 8 acyl, C 1 -C 18 alkoxy, C 1 -C 18 hydroxyalkoxy, C 2 -C 18 alkenyloxy, C 5 -C 12 cycloalkoxy, C 7 -C 12 phenylalkoxy unsubstituted or substituted on the phenyl radical by C 1 -C 4 alkyl and/or C 1 -C 4 alkoxy: C 1 -C 18 alkanoyloxy, (C 1 -C 18 alkoxy)carbonyl, glycidyl or a group —CH 2 CH(OH)(G) with G being hydrogen, methyl or phenyl; n is 1, 2, 3 or 4; and X is an organic radical of a valency equal to n; and when n is 2, 3 or 4, each of the radicals G 1 , G 2 , G 3 , G 4 and R can have the same or a different meaning in the units of the formula (II), is useful for stabilizing an organic material against degradation induced by light, heat or oxidation.

  式（I）的化合物，其中G1、G2、G3和G4彼此独立地是C1-C18烷基或C5-C12环烷基，或者基团G1和G2以及基团G3和G4彼此独立地与它们附着的碳原子一起形成C5-C12环烷基；R是氢、C1-C18烷基、氧基、—OH、—CH2CN、C3-C6烯基、C3-C8炔基、C7-C12苯基烷基，未取代或通过C1-C4烷基和/或C1-C4烷氧基取代苯基上的苯基基团；C1-C8酰基、C1-C18烷氧基、C1-C18羟基烷氧基、C2-C18烯氧基、C5-C12环烷氧基，未取代或通过C1-C4烷基和/或C1-C4烷氧基取代苯基上的C7-C12苯基氧基；C1-C18烷酰氧基、（C1-C18烷氧基）羰基、环氧乙基或一个基团—CH2CH(OH)(G)，其中G是氢、甲基或苯基；n为1、2、3或4；X是价数等于n的有机基团；当n为2、3或4时，式（II）的各单元中的G1、G2、G3、G4和R的每一个可以具有相同或不同的含义，对于抵抗光、热或氧化引起的有机材料降解具有稳定作用。
• Bisphenol Monoester compound
  申请人：Soma Ryoji

  公开号：US20090143517A1

  公开（公告）日：2009-06-04

  A bisphenol monoester compound represented by the formula (1): (in the formula (1), Rs each represent independently a hydrogen atom or a methyl group, and R′ represents an alkyl group of a carbon number of 1 to 6, or a hydrogen atom).

  由以下公式表示的双酚单酯化合物： （在公式（1）中，Rs分别独立表示氢原子或甲基基团，R′表示碳数为1至6的烷基基团，或氢原子）。