2,4'-diphenylmethane-bis(methyl) carbamate | 78948-89-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4'-diphenylmethane-bis(methyl) carbamate
• 英文别名: methyl N-[2-[[4-(methoxycarbonylamino)phenyl]methyl]phenyl]carbamate
• CAS: 78948-89-7
• 化学式: C₁₇H₁₈N₂O₄
• 分子量: 314.341
• InChiKey: LMRNRCPDGBDDQN-UHFFFAOYSA-N

物化性质

• 沸点：
  392.4±35.0 °C(Predicted)
• 密度：
  1.268±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  三聚甲醛 、 N-苯基香豆甲酯 在 硫酸 作用下， 以 水 为溶剂， 生成 2,4'-diphenylmethane-bis(methyl) carbamate 、 N,N'-(亚甲基二-4,1-亚苯基)二-氨基甲酸 C,C'-二甲基酯
  参考文献：
  名称：

  Catalytic synthesis of methylene diphenyl dicarbamate from methyl phenyl carbamate and trioxane over sulfuric acid catalyst

  摘要：

  甲基二苯基二氨甲酸酯（MDC）以硫酸（H2SO4）为催化剂，由甲基苯基氨甲酸酯（MPC）和三氧甲烷合成。详细研究了反应温度、反应时间、反应物摩尔比和催化剂含量等的影响。结果表明，H2SO4具有适中反应速率的高催化活性。在MPC与三氧甲烷摩尔比为3:1、反应温度为95°C、反应时间为3.5小时和30% H2SO4的条件下，MPC的转化率达到99.0%，MDC的选择性为81.6%。此外，H2SO4催化剂重复使用五次，活性无明显下降。根据副产物的鉴定，提出了可能的反应机理。

  DOI：

  10.1007/s11458-009-0207-4

文献信息

• METHOD FOR PREPARING POLYMETHYLENE POLYPHENYL POLYAMINO FORMATE
  申请人：Institute of Process Engineering, Chinese Academy of Sciences

  公开号：EP2752405A1

  公开（公告）日：2014-07-09

  A method for preparing polymethylene polyphenyl polycarbamate is provided, which is carried out through the condensation of phenylcarbamate with a methylating reagent under the catalyzation of a phase transfer acid catalyst. The method comprises: dissolving phenylcarbamate in a water-immiscible organic solvent to form a solution A; formulating an aqueous acid catalyst solution to form a solution B; forming a reaction system comprising an organic phase and an aqueous phase by firstly adding a methylating reagent to the solution B and then mixing the solution A and the solution B or by adding the methylating reagent at the same time of mixing the solution A and the solution B or after mixing the solution A and the solution B; reacting the reaction system under stirring at a reaction temperature of 30°C to 200°C and a reaction pressure of 0.05MPa to 5MPa; and separating a polymethylene polyphenyl polycarbamate product mixture by allowing the organic phase and the aqueous phase to stand still and stratify. The method can realize the high selectivity and yield of the product and is easy to separate the product.

  本发明提供了一种制备聚亚甲基聚苯基聚氨基甲酸酯的方法，该方法是在相转移酸催化剂的催化下，通过苯基氨基甲酸酯与甲基化试剂的缩合来实现的。该方法包括将苯基氨基甲酸酯溶解在不溶于水的有机溶剂中，形成溶液 A； 配制酸催化剂水溶液，形成溶液 B；先在溶液 B 中加入甲基化试剂，然后混合溶液 A 和溶液 B，或在混合溶液 A 和溶液 B 的同时加入甲基化试剂，或在混合溶液 A 和溶液 B 之后加入甲基化试剂，形成包括有机相和水相的反应体系；在搅拌下，在反应温度为 30°C 至 200°C 和反应压力为 0.05MPa 至 5MPa；通过使有机相和水相静止并分层，分离出聚亚甲基聚苯基聚氨基甲酸酯产品混合物。该方法可实现产品的高选择性和高产率，且易于分离产品。
• METHOD FOR PREPARING POLYMETHYLENE POLYPHENYL POLYCARBAMATE
  申请人：Li Huiquan

  公开号：US20140316100A1

  公开（公告）日：2014-10-23

  A method for preparing polymethylene polyphenyl polycarbamate is provided, which is carried out through the condensation of phenylcarbamate with a methylating reagent under the catalyzation of a phase transfer acid catalyst. The method comprises: dissolving phenylcarbamate in a water-immiscible organic solvent to form a solution A; formulating an aqueous acid catalyst solution to fibrin a solution B; forming a reaction system comprising an organic phase and an aqueous phase by firstly adding a methylating reagent to the solution B and then mixing the solution A and the solution B or by adding the methylating reagent at the same time of mixing the solution A and the solution B or after mixing the solution A and the solution B; reacting the reaction system under stirring at a reaction temperature of 30° C. to 200° C. and a reaction pressure of 0.05 MPa to 5 MPa; and separating a polymethylene polyphenyl polycarbamate product mixture by allowing the organic phase and the aqueous phase to stand still and stratify. The method can realize the high selectivity and yield of the product and is easy to separate the product.
• POLYISOCYANATE MONOMER COMPOSITION FOR OPTICAL MEMBERS, AND OPTICAL MEMBER AND PRODUCTION METHOD THEREFOR
  申请人：HOYA LENS THAILAND Ltd.

  公开号：US20170137560A1

  公开（公告）日：2017-05-18

  Provided are a polyisocyanate monomer composition for optical members, from which an optical members with which turbidity and clouding are difficult to occur during the production thereof, and which is excellent in transparency, can be obtained, and an optical member and production methods therefor. A polyisocyanate monomer composition for optical members, including 4,4′-diphenylmethane diisocyanate and at least one kind selected from 2,4′-diphenylmethane diisocyanate and 2,2′-diphenylmethane diisocyanate; an optical member formed of a polymer having a structure represented by the following formula (1), and at least one kind of structure represented by the following formula (2) or (3); and a method for producing an optical member, including a step of polymerizing a monomer composition including a polyisocyanate compound including 4,4′-diphenylmethane diisocyanate and at least one kind selected from 2,4′-diphenylmethane diisocyanate and 2,2′-diphenylmethane diisocyanate, and at least one kind selected from a polythiol compound and a polyol compound.
• US9062161B2
  申请人：——

  公开号：US9062161B2

  公开（公告）日：2015-06-23
• Catalytic synthesis of methylene diphenyl dicarbamate from methyl phenyl carbamate and trioxane over sulfuric acid catalyst
  作者：Tao Li、Huiquan Li、Guotong Qin、Haitao Liu、Yixia Pei

  DOI：10.1007/s11458-009-0207-4

  日期：2010.3

  Methylene diphenyl dicarbamate (MDC) was synthesized from methyl phenyl carbamate (MPC) and trioxane using sulfuric acid (H2SO4) as catalyst. The effects of reaction temperature, reaction time, molar ratio of reactants and the content of catalyst have been studied in details. The results showed that H2SO4 exhibited high catalytic activity with the merits of moderate reaction velocity. Under the conditions of n(MPC)/n(trioxane) = 3:1, reaction temperature of 95°C, reaction time of 3.5 h and 30% H2SO4, the conversion of MPC reached 99.0% with the selectivity of MDC 81.6%. Moreover, the H2SO4 catalyst was reused five times without obviously activity decrease. Based on the identification of byproducts, a possible reaction mechanism was proposed.

  甲基二苯基二氨甲酸酯（MDC）以硫酸（H2SO4）为催化剂，由甲基苯基氨甲酸酯（MPC）和三氧甲烷合成。详细研究了反应温度、反应时间、反应物摩尔比和催化剂含量等的影响。结果表明，H2SO4具有适中反应速率的高催化活性。在MPC与三氧甲烷摩尔比为3:1、反应温度为95°C、反应时间为3.5小时和30% H2SO4的条件下，MPC的转化率达到99.0%，MDC的选择性为81.6%。此外，H2SO4催化剂重复使用五次，活性无明显下降。根据副产物的鉴定，提出了可能的反应机理。