tert-butyl (5-bromo-2-nitrophenyl)carbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl (5-bromo-2-nitrophenyl)carbamate
• 英文别名: tert-butyl N-(5-bromo-2-nitrophenyl)carbamate
• 化学式: C₁₁H₁₃BrN₂O₄
• 分子量: 317.139
• InChiKey: ICMYLCQZXHYLHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  84.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl (5-bromo-2-nitrophenyl)carbamate 在 盐酸 、 iron(III) chloride 、 四(三苯基膦)钯 、 sodium carbonate 、 一水合肼 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 12.0h， 生成 4-(thiophen-2-yl)benzene-1,2-diamine
  参考文献：
  名称：

  Synthesis and Antimicrobial Activity of Novel Substituted 4-[3-(1H-Benzimidazol-2-yl)-4-hydroxybenzyl]-2-(1H-benzimidazol-2-yl)phenol Derivatives

  摘要：

  A series of novel substituted bis-benzimidazole derivatives were synthesized by reaction of 5,5'-methylenebis(2-hydroxybenzaldehyde) with various substituted o-phenylenediamines in glacial acetic acid. The structure of the newly synthesized compounds was elucidated by H-1 and C-13 NMR, FT-IR, and MS spectra, and their antimicrobial activity against gram positive and gram negative bacteria and antifungal activity were evaluated. The thienyl-substituted derivative showed significant activity against Bacillus licheniformis, Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumonia (bacteria), and Fusarium solani (fungi). The activities of the fluoro-substituted substituted derivative against some bacterial strains and of the thienyl-substituted derivative against fungi were found to be similar to those of standard drugs.

  DOI：

  10.1134/s1070363217120477
• 作为产物：
  描述：

  二碳酸二叔丁酯 、 5-溴-2-硝基苯胺 在 一水合肼 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以52%的产率得到tert-butyl (5-bromo-2-nitrophenyl)carbamate
  参考文献：
  名称：

  Inhibitors of histone deacetylase

  摘要：

  本发明涉及以下式(I)的化合物： 或其药学上可接受的盐、水合物、溶剂合物或前药，其中U、J、V、X、R2a、R2b、R2c、R5和t如本文所述。本发明一般涉及组织脱乙酰酶抑制剂及其制备和使用方法。这些化合物对促进认知功能、增强学习和记忆形成有用。此外，这些化合物对治疗、缓解和/或预防各种疾病条件有用，例如神经系统疾病、记忆和认知功能障碍/损伤、消退学习障碍、真菌疾病和感染、炎症性疾病、血液病和人类及动物的肿瘤性疾病。

  公开号：

  US09365498B2

文献信息

• Visible-Light-Mediated Nitration of Protected Anilines
  作者：Simon J. S. Düsel、Burkhard König

  DOI：10.1021/acs.joc.7b03260

  日期：2018.3.2

  The photocatalytic nitration of protected anilines proceeds with riboflavin tetraacetate as an organic photoredox catalyst. Sodium nitrite serves as the NO2 source in this visible-light-driven room temperature reaction. Various nitroanilines are obtained in moderate to good yields without the addition of acid or stoichiometric oxidation agents. The catalytic cycle is closed by aerial oxygen as the

  受保护的苯胺的光催化硝化反应以核黄素四乙酸盐作为有机光氧化还原催化剂进行。在此可见光驱动的室温反应中，亚硝酸钠用作NO 2源。在不添加酸或化学计量的氧化剂的情况下，以中等至良好的产率获得了各种硝基苯胺。催化循环被作为末端氧化剂的空气氧封闭。
• Inhibitors of Histone Deacetylase
  申请人：Moradei Oscar

  公开号：US20080132503A1

  公开（公告）日：2008-06-05

  The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

  本发明涉及抑制组蛋白去乙酰化酶。本发明提供了抑制组蛋白去乙酰化酶酶活性的化合物和方法。本发明还提供了治疗细胞增殖性疾病和病症的组合物和方法。
• INHIBITORS OF HISTONE DEACETYLASE
  申请人：The Broad Institute, Inc.

  公开号：US20160251351A1

  公开（公告）日：2016-09-01

  The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R 1a , R 2b , R 2c , R 5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.

  本发明涉及化合物式(I)或其药学上可接受的盐、水合物、溶剂合物或前药，其中U、J、V、X、R1a、R2b、R2c、R5和t如本文所述。本发明通常涉及组织脱乙酰化酶抑制剂及其制备和使用方法。这些化合物有助于促进认知功能，增强学习和记忆形成。此外，这些化合物在治疗、缓解和/或预防各种疾病方面也很有用，包括例如神经系统疾病、记忆和认知功能障碍、消退学习障碍、真菌疾病和感染、炎症性疾病、血液疾病和动物的肿瘤性疾病。
• COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF
  申请人：Revolution Medicines, Inc.

  公开号：US20200197391A1

  公开（公告）日：2020-06-25

  The disclosure features macrocyclic compounds, alone and in combination with other therapeutic agents, as well as pharmaceutical compositions and protein complexes thereof, capable of modulating biological processes including RAS and RAS-RAF inhibition, and their uses in the treatment of cancers.
• US9365498B2
  申请人：——

  公开号：US9365498B2

  公开（公告）日：2016-06-14