benzhydryl 4-acetylbenzoate | 266679-85-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzhydryl 4-acetylbenzoate
• CAS: 266679-85-0
• 化学式: C₂₂H₁₈O₃
• 分子量: 330.383
• InChiKey: ICTICDNXPUDCIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  benzhydryl 4-acetylbenzoate 在 4-二甲氨基吡啶 、 sodium hydroxide 、 盐酸羟胺 、 potassium carbonate 、 三乙胺 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 苯甲醚 、 丙酮 为溶剂， 反应 52.67h， 生成 4-{1-[(E)-1-Benzylcarbamoyl-3,3-diethyl-4-oxo-azetidin-2-yloxyimino]-ethyl}-benzoic acid
  参考文献：
  名称：

  Synthesis, inhibitory activity towards human leukocyte elastase and molecular modelling studies of 1-carbamoyl-4-methyleneaminoxyazetidinones

  摘要：

  Some monocyclic beta-lactam derivatives of type 3 (MAOAs) in which the leaving group (LG) on the C(4) is a methyleneaminoxy moiety, were synthesised and tested in vitro and in vivo for their inhibitory activity towards human leukocyte elastase (HLE). Some compounds showed an appreciable in vitro inhibitory activity against this enzyme. Effects on the anti-HLE activity due to the nature of the substituents R and R-1 present on their LG were observed and rationalised by means of molecular modelling techniques. The results of in vivo pharmacological tests indicated that MAOAs, while showing an inhibitory activity on the haemorrhage induced by HLE, did not exhibit any effects due to the R and R-1 substituents. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

  DOI：

  10.1016/s0223-5234(00)00111-2
• 作为产物：
  描述：

  二苯甲醇 在 18-冠醚-6 、 三氟化硼乙醚 、 potassium hydroxide 作用下， 以 1,2-二氯乙烷 、 甲苯 为溶剂， 反应 11.0h， 生成 benzhydryl 4-acetylbenzoate
  参考文献：
  名称：

  用三氟化硼·二乙醚催化从2-二苯基甲氧基吡啶容易地合成二苯基甲酯

  摘要：

  描述了一种由2-二苯基甲氧基吡啶直接制备二苯基甲基（DPM）酯的实用方法。该反应在室温下在催化量的三氟化硼-二乙基醚化物的存在下容易地进行。使用该反应方案，可以将各种羧酸高产率地转化为DPM酯。该方法对于保护羧酸和DPM酯的合成非常有效，并且为各种羧酸的简便酯化提供了一种有希望的方法。

  DOI：

  10.1016/j.tetlet.2018.04.002

文献信息

• Facile synthesis of diphenylmethyl esters from 2-diphenylmethoxypyridine using catalytic boron trifluoride·diethyl etherate
  作者：Minh Thanh La、Hee-Kwon Kim

  DOI：10.1016/j.tetlet.2018.04.002

  日期：2018.5

  A practical method for the direct preparation of diphenylmethyl (DPM) esters from 2-diphenylmethoxypyridine is described. The reaction was readily performed in the presence of a catalytic amount of boron trifluoride-diethyl etherate at room temperature. Using this reaction protocol, various carboxylic acids were converted to DPM esters with high yields. This method is highly effective for the protection

  描述了一种由2-二苯基甲氧基吡啶直接制备二苯基甲基（DPM）酯的实用方法。该反应在室温下在催化量的三氟化硼-二乙基醚化物的存在下容易地进行。使用该反应方案，可以将各种羧酸高产率地转化为DPM酯。该方法对于保护羧酸和DPM酯的合成非常有效，并且为各种羧酸的简便酯化提供了一种有希望的方法。
• Synthesis, inhibitory activity towards human leukocyte elastase and molecular modelling studies of 1-carbamoyl-4-methyleneaminoxyazetidinones
  作者：B Macchia

  DOI：10.1016/s0223-5234(00)00111-2

  日期：2000.1

  Some monocyclic beta-lactam derivatives of type 3 (MAOAs) in which the leaving group (LG) on the C(4) is a methyleneaminoxy moiety, were synthesised and tested in vitro and in vivo for their inhibitory activity towards human leukocyte elastase (HLE). Some compounds showed an appreciable in vitro inhibitory activity against this enzyme. Effects on the anti-HLE activity due to the nature of the substituents R and R-1 present on their LG were observed and rationalised by means of molecular modelling techniques. The results of in vivo pharmacological tests indicated that MAOAs, while showing an inhibitory activity on the haemorrhage induced by HLE, did not exhibit any effects due to the R and R-1 substituents. (C) 2000 Editions scientifiques et medicales Elsevier SAS.