N,N-dimethyl-1-octen-1-amide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N,N-dimethyl-1-octen-1-amide
• 英文别名: (E)-N,N-dimethylnon-2-enamide
• 化学式: C₁₁H₂₁NO
• 分子量: 183.294
• InChiKey: QUBRLLNXEPVZLW-MDZDMXLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  反式-1-碘-1-辛烯 、 N,N-二甲基甲酰胺 在 tris(dibenzylideneacetone)dipalladium (0) 三氯氧磷 作用下， 反应 36.0h， 生成 N,N-dimethyl-1-octen-1-amide
  参考文献：
  名称：

  Carbon Monoxide Free Aminocarbonylation of Aryl and Alkenyl Iodides Using DMF as an Amide Source

  摘要：

  [GRAPHIC]Palladium-catalyzed coupling reaction of N,N-dimethylformamide with aryl or alkenyl halides successfully proceeded in the presence of phosphoryl chloride to afford the corresponding tertiary amides in good yields.

  DOI：

  10.1021/ol026236k

文献信息

• Oxidative coupling of alkenes with amides using peroxides: selective amide C(sp³)–H versus C(sp²)–H functionalization
  作者：Xu-Heng Yang、Wen-Ting Wei、Hai-Bing Li、Ren-Jie Song、Jin-Heng Li

  DOI：10.1039/c4cc05051g

  日期：——

  described, in which mono- and difunctionalization of alkenes are selectively achieved. In this reaction with amides, the chemoselectivity toward the functionalization of the C(sp(3))-H bonds adjacent to the nitrogen atom or the functionalization of the carbonyl C(sp(2))-H bonds across alkenes relies on the reaction conditions.

  描述了使用过氧化物的未活化的末端烯烃与酰胺的新的氧化偶联，其中选择性地实现了烯烃的单官能化和双官能化。在与酰胺的反应中，对邻近氮原子的C（sp（3））-H键的官能化或整个烯烃上的羰基C（sp（2））-H键的化学选择性依赖于反应情况。
• NOVEL 1,3-BENZOXAZOL-2(3H)-ONES AND THEIR USE AS MEDICAMENTS AND COSMETICS
  申请人：DR. AUGUST WOLFF GMBH & CO. KG ARZNEIMITTEL

  公开号：US20150111935A1

  公开（公告）日：2015-04-23

  The present invention relates to a novel class of 1,3-benzoxazol-2(3H)-ones and their use as a medicament, preferably as a dermatologic agent, and as a cosmetic. These novel compounds are particularly useful in treating and/or preventing inflammation, irritation, itching, pruritus, pain, oedema and/or pro-allergic or allergic conditions in a patient. Usually they are topically applied to the skin or mucosa in the form of a pharmaceutical or cosmetic composition comprising the compound and a pharmaceutically and/or cosmetically acceptable carrier.

  本发明涉及一种新型的1,3-苯并噁唑-2(3H)-酮类化合物及其作为药物的用途，尤其是作为皮肤科药剂和化妆品的用途。这些新型化合物在治疗和/或预防患者的炎症、刺激、瘙痒、瘙痒、疼痛、水肿和/或过敏症状方面特别有用。通常它们以药用或化妆品组合物的形式局部应用于皮肤或黏膜，包括该化合物和一种药学和/或化妆学可接受的载体。
• US9199948B2
  申请人：——

  公开号：US9199948B2

  公开（公告）日：2015-12-01
• Carbon Monoxide Free Aminocarbonylation of Aryl and Alkenyl Iodides Using DMF as an Amide Source
  作者：Kazushi Hosoi、Kyoko Nozaki、Tamejiro Hiyama

  DOI：10.1021/ol026236k

  日期：2002.8.1

  [GRAPHIC]Palladium-catalyzed coupling reaction of N,N-dimethylformamide with aryl or alkenyl halides successfully proceeded in the presence of phosphoryl chloride to afford the corresponding tertiary amides in good yields.