申请人:Pfizer Inc.
公开号:US06342521B1
公开(公告)日:2002-01-29
A compound of the formula
wherein R1, R2 and Q is as defined above, are useful in the treatment of a arthritis (including osteoarthritis and rheumatoid arthritis), cancer (such as solid tumor cancer including colon cancer, breast cancer, lung cancer and prostrate cancer and hematopoietic malignancies including leukemias and lymphomas), and other disorders. In addition, the compounds of the present invention may be used in combination therapy with standard non-steroidal anti-inflammatory drugs (NSAID'S) and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinum, etoposide, taxol, taxotere and other alkaloids, such as vincristine, in the treatment of cancer.
该式中R1、R2和Q所定义的化合物,在治疗关节炎(包括骨关节炎和类风湿关节炎)、癌症(如实体肿瘤癌症,包括结肠癌、乳腺癌、肺癌和前列腺癌,以及血液系统恶性肿瘤,包括白血病和淋巴瘤)和其他疾病方面具有用处。此外,本发明的化合物可与标准非甾体抗炎药(NSAID'S)和镇痛药联合使用,也可与阿霉素、多柔红霉素、顺铂、依托泊苷、紫杉醇、多西紫杉醇和其他生物碱等细胞毒药物联合使用,用于癌症治疗。