Bis-<4-phenoxy-butyl>-amin | 19176-63-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Bis-<4-phenoxy-butyl>-amin
• 英文别名: bis-(4-phenoxy-butyl)-amine；δ.δ'-Diphenoxy-dibutylamin；Bis-(δ-phenoxy-butyl)-amin；4-Phenoxy-N-(4-phenoxybutyl)-1-butanamine；4-phenoxy-N-(4-phenoxybutyl)butan-1-amine
• CAS: 19176-63-7
• 化学式: C₂₀H₂₇NO₂
• 分子量: 313.44
• InChiKey: HZCPIFSZNGPFHO-UHFFFAOYSA-N

物化性质

• 沸点：
  241 °C(Press: 2 Torr)
• 密度：
  1.023±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  23
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Bis-<4-phenoxy-butyl>-amin 在 氢溴酸 作用下， 生成 bis-(4-bromo-butyl)-amine
  参考文献：
  名称：

  Cloning and Characterization of the Promoter Region of the Human CD83 Gene

  摘要：

  Human CD83 (hCD83) is a glycoprotein expressed predominantly on the surface of dendritic cells (DC). To get insight into the regulation of hCD83 expression, we cloned a 3037 by fragment upstream of the translation initiation codon. Deletion mutants were constructed revealing highest promoter activity in the -261 fragment containing four SP1 binding sites and one NF-kappaB element. Electrophoretic mobility shift assays demonstrated the specific interaction of NF-kappaB factors with the NF-kappaB element as well as specific binding of SP1 and SP3 to the SP1 binding site. The hCD83 promoter was inducible by TNF-alpha. This inducibility was strictly dependent on the intact NF-kappaB element.

  DOI：

  10.1078/0171-2985-00128
• 作为产物：
  描述：

  4-(苯氧基)丁腈 在 镍 、 环己醇 作用下， 110.0~130.0 ℃ 、2.03 MPa 条件下， 生成 Bis-<4-phenoxy-butyl>-amin
  参考文献：
  名称：

  Cloning and Characterization of the Promoter Region of the Human CD83 Gene

  摘要：

  Human CD83 (hCD83) is a glycoprotein expressed predominantly on the surface of dendritic cells (DC). To get insight into the regulation of hCD83 expression, we cloned a 3037 by fragment upstream of the translation initiation codon. Deletion mutants were constructed revealing highest promoter activity in the -261 fragment containing four SP1 binding sites and one NF-kappaB element. Electrophoretic mobility shift assays demonstrated the specific interaction of NF-kappaB factors with the NF-kappaB element as well as specific binding of SP1 and SP3 to the SP1 binding site. The hCD83 promoter was inducible by TNF-alpha. This inducibility was strictly dependent on the intact NF-kappaB element.

  DOI：

  10.1078/0171-2985-00128

文献信息

• Gaiffe,A.; Launay,C., Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1968, vol. 266, p. 471 - 472
  作者：Gaiffe,A.、Launay,C.

  DOI：——

  日期：——
• PROCESS FOR PRODUCING POLYDIENES
  申请人：QIN Zengquan

  公开号：US20120196995A1

  公开（公告）日：2012-08-02

  A process for preparing a polydiene, the process comprising the step of: polymerizing conjugated diene monomer in the presence of a (hydrocarbyloxyhydrocarbyl)amine, where said step of polymerizing employs a lanthanide-based catalyst system.
• US9000107B2
  申请人：——

  公开号：US9000107B2

  公开（公告）日：2015-04-07
• Cloning and Characterization of the Promoter Region of the Human CD83 Gene
  作者：S BERCHTOLD

  DOI：10.1078/0171-2985-00128

  日期：——

  Human CD83 (hCD83) is a glycoprotein expressed predominantly on the surface of dendritic cells (DC). To get insight into the regulation of hCD83 expression, we cloned a 3037 by fragment upstream of the translation initiation codon. Deletion mutants were constructed revealing highest promoter activity in the -261 fragment containing four SP1 binding sites and one NF-kappaB element. Electrophoretic mobility shift assays demonstrated the specific interaction of NF-kappaB factors with the NF-kappaB element as well as specific binding of SP1 and SP3 to the SP1 binding site. The hCD83 promoter was inducible by TNF-alpha. This inducibility was strictly dependent on the intact NF-kappaB element.