8-chloro-9,10-dioxo-9,10-dihydro-anthracene-1-carboxylic acid | 38366-33-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 8-chloro-9,10-dioxo-9,10-dihydro-anthracene-1-carboxylic acid
• 英文别名: 8-Chlor-9,10-dioxo-9,10-dihydro-anthracen-1-carbonsaeure；8-Chloro-9,10-dioxo-9,10-dihydroanthracene-1-carboxylic acid；8-chloro-9,10-dioxoanthracene-1-carboxylic acid
• CAS: 38366-33-5
• 化学式: C₁₅H₇ClO₄
• 分子量: 286.671
• InChiKey: KUDPRNGXHWPTPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  8-chloro-9,10-dioxo-9,10-dihydro-anthracene-1-carboxylic acid 在 copper(I) oxide 作用下， 生成 1-氯蒽醌
  参考文献：
  名称：

  Maki; Nagai, Kogyo Kagaku zasshi / Journal of the Society of Chemical Industry, Spl. 38 <1935> 487, 492

  摘要：

  DOI：
• 作为产物：
  描述：

  1-氯蒽醌 在 chromium(VI) oxide 、 硫酸 、 苯胺硫酸盐 、 溶剂黄146 作用下， 生成 8-chloro-9,10-dioxo-9,10-dihydro-anthracene-1-carboxylic acid
  参考文献：
  名称：

  Maki; Kikuchi, Chemische Berichte, 1938, vol. 71, p. 2031

  摘要：

  DOI：

文献信息

• Optically Active Triptycenes. IV. Synthesis of Optically Active 2- or 5-Substituted 7-Carboxytriptycenes
  作者：Yoshiteru Sakata、Fumio Ogura、Masazumi Nakagawa

  DOI：10.1246/bcsj.46.611

  日期：1973.2

  Starting from anthraquinone-1-carboxylic acid (I), 2-methoxy- and 5-methoxy-7-carboxytriptycenes (VIIa and VIIb) have been synthesized. Optical resolution of the triptycenecarboxylic acids with brucine afforded (+)-VIIa and (+)-VIIb. The absolute configuration of (+)-VIIa was determined to be 1R,6R by the chemical correlation with (+)-2,5-dimethoxy-7-methoxycarbonyltriptycene. From a comparison of

  以蒽醌-1-羧酸 (I) 为原料，已经合成了 2-甲氧基-和 5-甲氧基-7-羧基三烯 (VIIa 和 VIIb)。用丁香碱对三苯甲酸进行光学拆分，得到 (+)-VIIa 和 (+)-VIIb。(+)-VIIa 的绝对构型通过与 (+)-2,5-二甲氧基-7-甲氧基羰基三苯甲基的化学相关性确定为 1R,6R。从 (+)-5-甲氧基-7-羧基三烯 (VIIb) 的 CD 光谱与 (+)-2-乙酰氧基-5-甲氧基-7-甲氧基羰基三烯 (XIIIb) 的 CD 光谱的比较来看，1R,6R 绝对构型为分配给 (+)-VIIb。(+)-2-Hydroxy-5-phenylazo-7-carboxytriptycene (XIIa) 衍生自 (+)-VIIa。(+)-2-氯-和(+)-5-氯-7-羧基三苯乙烯(XVIIIa和XVIIIb)已经由5-氯-和8-氯-1-羧基蒽醌(XIVa和XIVb)制备。
• 115. The constitution of the chlorination products of benzanthrone
  作者：R. S. Cahn、W. O. Jones、J. L. Simonsen

  DOI：10.1039/jr9330000444

  日期：——
• Dissociation constants of 8-substituted 9,10-ethanoanthracene-1-carboxylic acids and related compounds. Evidence for the field model for the polar effect
  作者：Ronald Golden、Leon M. Stock

  DOI：10.1021/ja00764a032

  日期：1972.5
• Maki; Nagai, The journal of the Society of Chemical Industry, Japan. Supplemental binding., 1935, vol. 38, p. 487,492
  作者：Maki、Nagai

  DOI：——

  日期：——
• Intracranial subdural hematoma after unintended durotomy during spine surgery
  作者：Chueng-He Lu、Shung-Tai Ho、Shang-Shung Kong、Chen-Hwan Cherng、Chih-Shung Wong

  DOI：10.1007/bf03020428

  日期：2002.1

  Purpose: To report a case of intracranial subdural hematoma occurring after a spinal ducal tear that was made unintentionally during the course of a posterior laminectomy and spinal fusion at the L-5-S-1 level. The possible physiopathological mechanisms are discussed.Clinical features: On the fourth postoperative day, a 59-yr-old woman displayed persistent headache following unintended durotomy during spine implant revision. Perioperative blood loss was 2840 mL and intravascular replacement was about 3000 mL. She was hydrated with iv fluids and treated with non-steroidal anti-inflammatory drugs. The symptoms improved but persisted. With the aggravation of the headache complicated with unconsciousness and the appearance of focal neurological signs on the eighth day, a computed tomography was obtained and revealed a right subdural hematoma. Following surgical drainage, the patient made an uneventful recovery.Conclusion: This case reminds us that subdural hematoma formation can complicate durotomy during spine surgery. Neurological deterioration in the postoperative period should prompt clinicians to rule out the diagnosis and intervene rapidly as appropriate.