anthracen-9(10H)-one oxime | 92560-84-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: anthracen-9(10H)-one oxime
• 英文别名: anthrone oxime；anthron-oxime；9(10H)-Anthracenone, oxime；N-(10H-anthracen-9-ylidene)hydroxylamine
• CAS: 92560-84-4
• 化学式: C₁₄H₁₁NO
• 分子量: 209.247
• InChiKey: DHSLOIFKVQGCQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  32.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  anthracen-9(10H)-one oxime 在 五氯化磷 作用下， 反应 2.5h， 生成 6-chloromorphanthridine
  参考文献：
  名称：

  Sinha, Ashok Kumar; Nizamuddin, S., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1984, vol. 23, # 2, p. 165

  摘要：

  DOI：
• 作为产物：
  描述：

  9,10-二氢蒽 在 正丁基锂 、 亚硝酸特丁酯 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 0.5h， 以47%的产率得到anthracen-9(10H)-one oxime
  参考文献：
  名称：

  Formation of Xanthone Oxime and Related Compounds Using a Combination of tert-Butyl Nitrite and Potassium Hexamethyldisilazide

  摘要：

  Synthesis of xanthone oxime and related compounds via nitrosation of the dibenzylic position using a combination of tert-butyl nitrite and potassium hexamethyldisilazide is described. The reaction conditions are effective for the synthesis of xanthone oxime as well as thioxanthone, acridone, and anthrone oximes, which have been difficult to synthesize from the corresponding ketones by conventional dehydrative condensation with hydroxylamine.

  DOI：

  10.3987/com-13-s(s)110

文献信息

• OXIDATIVE DEPROTECTION OF OXIMES USING PYRIDINIUM FLUOROCHROMATE AND HYDROGEN PEROXIDE
  作者：Nemai C. Ganguly、Arun K. Sukai、Sripada De、Prithwiraj De

  DOI：10.1081/scc-100104075

  日期：2001.1

  A simple convenient procedure of oxidative deoximation has been developed using pyridinium fluorochromate (PFC), in combination with 30% hydrogen peroxide. The method has been found to be effective for a wide range of aliphatic and aromatic oximes, and may be used for selective cleavage of aldoximes in the presence of ketoximes.

  使用氟铬酸吡啶 (PFC) 与 30% 过氧化氢结合开发了一种简单方便的氧化脱肟程序。已发现该方法对多种脂肪族和芳香族肟有效，并可用于在酮肟存在下选择性裂解醛肟。
• REGENERATION OF CARBONYL COMPOUNDS BY OXIDATIVE CLEAVAGE OF CARBON-NITROGEN DOUBLE BONDS WITH MOLECULAR OXYGEN IN THE PRESENCE OF COPPER(I) CHLORIDE/KIESELGHUR AS CATALYST
  作者：Mohammed M. Hashemi、Yousef A. Beni

  DOI：10.1081/scc-100000213

  日期：2001.1

  Kieselghur-supported copper(I) chloride was found to be an efficient and convenient catalyst for the oxidative cleavage of oximes, phenylhydrazones, and p-nitrophenylhydrazones to the corresponding carbonyl compounds with molecular oxygen.

  发现 Kieselghur 负载的氯化铜 (I) 是一种有效且方便的催化剂，可用于将肟、苯腙和对硝基苯腙氧化裂解为具有分子氧的相应羰基化合物。
• SINHA, ASHOK, KUMAR;NIZAMUDDIN, S., INDIAN XJ. CHEM., 1984, 23, N 2, 165
  作者：SINHA, ASHOK, KUMAR、NIZAMUDDIN, S.

  DOI：——

  日期：——
• STABILIZED THERMOPLASTIC COMPOSITIONS
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP1137703A1

  公开（公告）日：2001-10-04
• SPIRO-CONTAINING COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS
  申请人：Michellys Pierre-Yves

  公开号：US20090124597A1

  公开（公告）日：2009-05-14

  Described herein are compounds that have a spiro structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of steroid hormone nuclear receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent diseases or conditions associated with the activity of steroid hormone nuclear receptors.