2-allyl-2-ethoxycarbonyl-pent-4-enoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-allyl-2-ethoxycarbonyl-pent-4-enoic acid
• 英文别名: 2-Ethoxycarbonyl-2-prop-2-enylpent-4-enoic acid
• 化学式: C₁₁H₁₆O₄
• 分子量: 212.246
• InChiKey: IJYIHGCBBZEQMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-allyl-2-ethoxycarbonyl-pent-4-enoic acid 在 sodium tetrahydroborate 作用下， 生成 (1R,2R,3R,5R)-3-Allyl-2-hydroxy-bicyclo[3.1.0]hexane-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  Reactions with .alpha.-diazo ketones. III. Stereochemical course of cyclization of some olefin-substituted .alpha.-diazo ketones

  摘要：

  DOI：

  10.1021/jo00929a028
• 作为产物：
  描述：

  二烯丙基丙二酸二乙酯 在 potassium hydroxide 作用下， 以 乙醇 为溶剂， 反应 6.0h， 以23%的产率得到2-allyl-2-ethoxycarbonyl-pent-4-enoic acid
  参考文献：
  名称：

  以甲酸为氢源的选择性和官能团耐受的钌催化烯烃复分解/转移加氢串联序列

  摘要：

  描述了利用甲酸作为氢供体的钌催化的烯烃的转移氢化。市售的亚烷基钌络合物的应用打开了在串联催化条件下烯烃复分解/转移氢化序列中有吸引力的C（sp3）-C（sp3）键形成的途径。所开发方法的高化学选择性为在温和的反应条件下还原各种官能化的烯烃提供了出色的合成工具。所开发的方法学用于药物戊氧基维林和苯环戊烷的正式合成。

  DOI：

  10.1021/acs.joc.7b02468

文献信息

• [EN] RUTHENIUM-BASED METATHESIS CATALYSTS AND PRECURSORS FOR THEIR PREPARATION<br/>[FR] CATALYSEURS DE MÉTATHÈSE À BASE DE RUTHÉNIUM ET PRÉCURSEURS POUR LEUR PRÉPARATION
  申请人：UMICORE AG & CO KG

  公开号：WO2013135776A1

  公开（公告）日：2013-09-19

  The invention is directed to ruthenium-based metathesis catalysts of the Hoveyda-Grubbs type. The new N-chelating diarylamino-based ruthenium catalysts described herein are stable in solid state and in solution and reveal rapid initiation behavior. Further, the corresponding N-substituted styrene precursor compounds are disclosed. The catalysts are prepared in a cross-metathesis reaction starting from N-substituted styrene precursors. The new Hoveyda-Grubbs type catalysts are suitable to catalyze ring- closing metathesis (RCM), cross metathesis (CM) and ring-opening metathesis polymerization (ROMP). Low catalyst loadings are sufficient to convert a wide range of substrates via metathesis reactions.

  该发明涉及霍维达-格鲁布斯类型的基于钌的重要烯烃交换催化剂。本文描述的新型N-螯合二芳胺基钌催化剂在固态和溶液中稳定，并显示出快速启动行为。此外，还披露了相应的N-取代苯乙烯前体化合物。这些催化剂是通过从N-取代苯乙烯前体出发的交叉烯烃交换反应制备的。新型的霍维达-格鲁布斯类型催化剂适用于催化环闭合烯烃交换（RCM）、交叉烯烃交换（CM）和环开启烯烃聚合（ROMP）。低催化剂负载量足以通过烯烃交换反应转化各种底物。
• Aminolactonization of Unactivated Alkenes Catalyzed by Aryl Iodine
  作者：Lu-Wen Zhang、Xiao-Jun Deng、Dong-Xu Zhang、Qin-Qin Tian、Wei He

  DOI：10.1021/acs.joc.1c00074

  日期：2021.4.2

  protocol of the aryl iodine-catalyzed aminolactonization of unactivated alkenes under oxidation conditions was first reported to efficiently construct diverse amino lactones in a short time using HNTs2 as the compatible nitrogen source. In addition, we investigated the influence of the reaction rate based on the structure of the iodoarene precatalyst, which revealed the selective adjustment effect on aminolactonization

  首次报道了在氧化条件下芳基碘催化未活化烯烃的氨基内酯化的一步协议，可使用HNTs 2作为相容氮源在短时间内有效构建各种氨基内酯。此外，我们基于碘芳烃预催化剂的结构研究了反应速率的影响，揭示了对氨基内酯化和氧内酯化的选择性调节作用。最后，初步实验验证了手性碘芳烃预催化剂催化不对称氨基内酯化的可行性。
• NOVEL FLUOROPOLYMER, RESIST COMPOSITIONS CONTAINING THE SAME, AND NOVEL FLUOROMONOMERS
  申请人：Daikin Industries, Ltd.

  公开号：EP1449860A1

  公开（公告）日：2004-08-25

  There is provided a fluorine-containing copolymer having an aliphatic monocyclic structure in the polymer trunk chain which has a number average molecular weight of from 500 to 1,000,000 and is represented by the formula (Ma):         - (M1) - (M2a) - (N) -     (Ma) in which the structural unit M1 is a structural unit derived from an ethylenic monomer having 2 or 3 carbon atoms and at least one fluorine atom, the structural unit M2a is at least one structural unit which introduces an aliphatic monocyclic structure in the polymer trunk chain and is represented by the formula (a): wherein R1 is at least one hydrocarbon group selected from the group consisting of a divalent hydrocarbon group having 1 to 8 carbon atoms and constituting a ring which may be further substituted with a hydrocarbon group or a fluorine-containing alkyl group and a divalent hydrocarbon group having ether bond which has the sum of carbon atoms and oxygen atoms of 2 to 8, constitutes a ring and may be further substituted with a hydrocarbon group or a fluorine-containing alkyl group; R2 is an alkylene group which has 1 to 3 carbon atoms and constitutes a ring; R3 and R4 are the same or different and each is a divalent alkylene group which has 1 or 2 carbon atoms and constitutes a ring; n1, n2 and n3 are the same or different and each is 0 or 1, the structural unit N is a structural unit derived from a monomer copolymerizable with the monomers to introduce the structural units M1 and M2a, and the structural units M1, M2a and N are contained in amounts of from 1 to 99 % by mole, from 1 to 99 % by mole and from 0 to 98 % by mole, respectively. The fluorine-containing polymer possesses excellent dry etching resistance and transparency in a vacuum ultraviolet region.

  有一种含氟共聚物，其聚合物主链具有脂肪族单环结构，其平均分子量为 500 至 1,000,000 之间，由式（Ma）表示： - (M1) - (M2a) - (N) - (Ma) 其中 结构单元 M1 是由具有 2 个或 3 个碳原子和至少一个氟原子的乙烯基单体衍生的结构单元， 结构单元 M2a 是在聚合物主链中引入脂肪族单环结构的至少一个结构单元，由式（a）表示： 其中 R1 是至少一个烃基，该烃基选自以下组别：具有 1 至 8 个碳原子的二价烃基，该烃基构成环，可进一步被烃基或含氟烷基取代；具有醚键的二价烃基，该烃基的碳原子和氧原子之和为 2 至 8，构成环，可进一步被烃基或含氟烷基取代；R2 是具有 1 至 3 个碳原子并构成环的亚烷基； R3 和 R4 相同或不同，且各自是具有 1 或 2 个碳原子并构成环的二价亚烷基； n1、n2 和 n3 相同或不同，且各自为 0 或 1， 结构单元 N 是衍生自可与单体共聚以引入结构单元 M1 和 M2a 的单体的结构单元，且 结构单元 M1、M2a 和 N 的含量分别为 1-99%（摩尔）、1-99%（摩尔）和 0-98%（摩尔）。这种含氟聚合物具有优异的耐干蚀刻性和在真空紫外线区域的透明度。
• Novel fluorine-containing polymer, resist composition prepared from same and novel fluorine-containing monomer
  申请人：DAIKIN INDUSTRIES, LTD.

  公开号：US20040191680A1

  公开（公告）日：2004-09-30

  There is provided a fluorine-containing copolymer having an aliphatic monocyclic structure in the polymer trunk chain which has a number average molecular weight of from 500 to 1,000,000 and is represented by the formula (Ma): —(M1)—(M2a)—(N)—(Ma)—  (Ma) in which the structural unit M1 is a structural unit derived from an ethylenic monomer having 2 or 3 carbon atoms and at least one fluorine atom, the structural unit M2a is at least one structural unit which introduces an aliphatic monocyclic structure in the polymer trunk chain and is represented by the formula (a): 1 wherein R 1 is at least one hydrocarbon group selected from the group consisting of a divalent hydrocarbon group having 1 to 8 carbon atoms and constituting a ring which may be further substituted with a hydrocarbon group or a fluorine-containing alkyl group and a divalent hydrocarbon group having ether bond which has the sum of carbon atoms and oxygen atoms of 2 to 8, constitutes a ring and may be further substituted with a hydrocarbon group or a fluorine-containing alkyl group; R 2 is an alkylene group which has 1 to 3 carbon atoms and constitutes a ring; R 3 and R 4 are the same or different and each is a divalent alkylene group which has 1 or 2 carbon atoms and constitutes a ring; n1, n2 and n3 are the same or different and each is 0 or 1, the structural unit N is a structural unit derived from a monomer copolymerizable with the monomers to introduce the structural units M1 and M2a, and the structural units M1, M2a and N are contained in amounts of from 1 to 99% by mole, from 1 to 99% by mole and from 0 to 98% by mole, respectively. The fluorine-containing polymer possesses excellent dry etching resistance and transparency in a vacuum ultraviolet region.

  提供了一种含氟共聚物，其聚合物主链中具有脂肪族单环结构，其平均分子量为 500 至 1,000,000 之间，并由式(Ma)表示： -(M1)-(M2a)-(N)-(Ma)- (Ma) 其中 结构单元 M1 是由具有 2 个或 3 个碳原子和至少一个氟原子的乙烯基单体衍生的结构单元，结构单元 M2a 是在聚合物主链中引入脂肪族单环结构的至少一个结构单元，由式（a）表示： 1 其中 R 1 是至少一个烃基，选自由以下组成的组：一个二价烃基，具有 1 至 8 个碳原子，构成一个环，可进一步被一个烃基或一个含氟烷基取代；一个二价烃基，具有醚键，碳原子和氧原子之和为 2 至 8，构成一个环，可进一步被一个烃基或一个含氟烷基取代。 2 是具有 1 至 3 个碳原子并构成环的亚烷基；R 3 和 R 4 结构单元 N 是可与单体共聚以引入结构单元 M1 和 M2a 的单体衍生的结构单元，且 结构单元 M1、M2a 和 N 的含量分别为 1-99%（摩尔）、1-99%（摩尔）和 0-98%（摩尔）。含氟聚合物具有优异的耐干蚀刻性和在真空紫外线区域的透明度。
• IMIDAZOLIDINE-BASED METAL CARBENE METATHESIS CATALYSTS
  申请人：CALIFORNIA INSTITUTE OF TECHNOLOGY

  公开号：EP1180108A2

  公开（公告）日：2002-02-20