4-(tert-butyldimethylsilyloxymethyl)-2,6-dichloropyridine | 221095-71-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(tert-butyldimethylsilyloxymethyl)-2,6-dichloropyridine
• 英文别名: 2,6-dichloro-4-(tert-butyldimethylsilanyloxymethyl)pyridine；2,6-dichloro-4-((1,1-dimethylethyl)dimethylsilyl)oxymethylpyridine；4-(tert-butyl-dimethyl-silanyloxymethyl)-2,6-dichloro-pyridine；tert-butyl-[(2,6-dichloropyridin-4-yl)methoxy]-dimethylsilane
• CAS: 221095-71-2
• 化学式: C₁₂H₁₉Cl₂NOSi
• 分子量: 292.28
• InChiKey: XOQGQQKOLJWVDQ-UHFFFAOYSA-N

物化性质

• 沸点：
  328.1±37.0 °C(Predicted)
• 密度：
  1.106±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.91
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(tert-butyldimethylsilyloxymethyl)-2,6-dichloropyridine 在 sodium tetrahydroborate 、 tris(dibenzylideneacetone)dipalladium (0) 、 三叔丁基膦 、 caesium carbonate 、 nickel dichloride 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  逆转发现范式：荧光化学传感器组合发现的新方法

  摘要：

  我们在这里报告了一种发现荧光化学传感器的新方法，其中一种新的信号机制允许核心荧光团用于新结合事件的组合搜索，从而扭转了主导的发现范式。

  DOI：

  10.1021/ja043682p
• 作为产物：
  描述：

  柠嗪酸 在 咪唑 、 4-二甲氨基吡啶 、 lithium hydroxide 、 dimethyl sulfide borane 、 三氯氧磷 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 32.5h， 生成 4-(tert-butyldimethylsilyloxymethyl)-2,6-dichloropyridine
  参考文献：
  名称：

  逆转发现范式：荧光化学传感器组合发现的新方法

  摘要：

  我们在这里报告了一种发现荧光化学传感器的新方法，其中一种新的信号机制允许核心荧光团用于新结合事件的组合搜索，从而扭转了主导的发现范式。

  DOI：

  10.1021/ja043682p

文献信息

• MODULATORS FOR AMYLOID BETA
  申请人：Baumann Karlheinz

  公开号：US20090215759A1

  公开（公告）日：2009-08-27

  The invention relates to compounds of formula wherein the substituents are as described in claim 1 . Compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.

  该发明涉及以下式的化合物 其中取代基如权利要求中所述 。式I的化合物是淀粉样蛋白β的调节剂，因此它们可能对治疗或预防与大脑中β-淀粉样蛋白沉积相关的疾病有用，特别是阿尔茨海默病，以及其他疾病，如脑淀粉样血管病变，遗传性脑出血伴淀粉样变性，荷兰型（HCHWA-D），多梗死性痴呆，拳击性痴呆和唐氏综合征。
• Tyrosine kinase inhibitors
  申请人：——

  公开号：US20030100567A1

  公开（公告）日：2003-05-29

  The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.

  本发明涉及抑制、调节和/或调节酪氨酸激酶信号传导的化合物，包含这些化合物的组合物，以及使用它们治疗酪氨酸激酶依赖性疾病和情况的方法，例如在哺乳动物中的血管生成、癌症、肿瘤生长、动脉粥样硬化、年龄相关性黄斑变性、糖尿病性视网膜病变、炎症性疾病等。
• Multi-functionalized 2,2′:6′,2′′-Terpyridines
  作者：Marcel Heller、Ulrich S. Schubert

  DOI：10.1055/s-2002-25357

  日期：——

  In this contribution, Stille-type cross-coupling procedure is shown to be an easy and universal way to prepare a variety of functionalized terpyridines. They may be functionalized in one step with different substituents at the outer pyridine rings and at the 4′-position of the centered ring, leading to multi-functionalized compounds. The initially obtained methylester and ethylester groups may be simply converted into bromomethyl and hydroxymethyl groups, which allow further functionalization reactions.

  在这篇论文中，Stille 型交叉偶联程序被证明是制备各种官能化特吡啶的一种简单而通用的方法。它们可以通过在吡啶外环和中心环的 4′-位上添加不同的取代基一步完成官能化，从而得到多官能化合物。最初得到的甲酯和乙酯基团可以简单地转化为溴甲基和羟甲基基团，从而进行进一步的官能化反应。
• 2,6-dichloro-4-pyridinemethanol derivatives and agricultural chemicals
  申请人：Dainippon Ink and Chemical, Inc.

  公开号：US06281231B1

  公开（公告）日：2001-08-28

  The object is to provide a novel compound, with which there is little possibility of phytotoxicity for crop plants, and which is greatly effective in controlling various plant diseases caused by viruses pathogenic to plants, by bacteria, and by molds, and to provide agricultural chemicals, particularly agents for controlling plant diseases, containing this compound, 2,6-dichloro-4-pyridinemethanol, and/or a benzoic acid ester thereof as an active ingredient. As means for achieving the object, 2,6-dichloro-4-pyridinemethanol derivatives, 2,6-dichloro-4-pyridinemethanol, benzoic acid esters thereof, and agricultural chemicals containing these compounds as active ingredients are provided, the 2,6-dichloro-4-pyridinemethanol derivative being expressed by general formula (1): wherein W denotes an optionally substituted C1 to C8 alkyl group, a trifluoromethylpyridyl group, —COR1, —SO2R2, —PO(OR3)2, —CONHR4, —COOR4, —COCOR4, or —SiR5R6R7, in which: R1 denotes an optionally substituted C1 to C18 alkyl group, an optionally substituted C1 to C18 alkenyl group, a phenyl group which has one or more specific substituent groups, or a 5- or 6-membered heterocyclic ring residue which has any one of a nitrogen atom, an oxygen atom, or a sulfur atom as a ring component atom; R2 denotes an alkyl group or a phenyl group; R3 denotes an alkyl group; R4 denotes an alkyl group or a phenyl group; and each of R5 to R7 denotes an alkyl group.

  本发明的目的是提供一种新型化合物，该化合物对作物植物具有很小的植物毒性可能性，并且在控制由病毒、细菌和霉菌引起的各种植物疾病方面具有极大的有效性，并提供含有此化合物2,6-二氯-4-吡啶甲醇和/或其苯甲酸酯作为活性成分的农药化学品，特别是用于控制植物疾病的药剂。为了实现这一目的，提供了2,6-二氯-4-吡啶甲醇衍生物、2,6-二氯-4-吡啶甲醇、其苯甲酸酯以及含有这些化合物作为活性成分的农药化学品，其中2,6-二氯-4-吡啶甲醇衍生物由通式（1）表示：其中W表示可选取代的C1至C8烷基、三氟甲基吡啶基、—COR1、—SO2R2、—PO（OR3）2、—CONHR4、—COOR4、—COCOR4或—SiR5R6R7，其中：R1表示可选取代的C1至C18烷基、可选取代的C1至C18烯基、具有一个或多个特定取代基的苯基或具有氮原子、氧原子或硫原子中的任一种作为环组分原子的5-或6-成员杂环环残基；R2表示烷基或苯基；R3表示烷基；R4表示烷基或苯基；且R5至R7中的每一个表示烷基。
• Functionalized 2,2‘-Bipyridines and 2,2‘:6‘,2‘ ‘-Terpyridines via Stille-Type Cross-Coupling Procedures
  作者：Marcel Heller、Ulrich S. Schubert

  DOI：10.1021/jo0260600

  日期：2002.11.1

  Stille-type cross-coupling procedures are utilized in order to prepare a variety of fanctionalized 2,2'-bipyridines and 2,2':6',2"-terpyridines. Such N-heterocyclic compounds are of great interest as chelating ligands for transition-metal ions in the field of supramolecular chemistry. Various mono- and disubstitued 2,2'-bipyridines were synthesized in high yields and multigram scales using a modular design principle. The terpyridines may be functionalized in one step with different substituents at the outer pyridine rings and at the 4'-position of the centered ring, leading to multifunctionalized compounds. The initially obtained methyl ester and ethyl ester groups can be simply converted into bromomethyl and hydroxymethyl groups which allow further functionalization reactions.