3-Methoxy-4,5-diphenylmethylenedioxybenzyl alcohol | 883841-91-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Methoxy-4,5-diphenylmethylenedioxybenzyl alcohol
• 英文别名: (7-methoxy-2,2-diphenyl-1,3-benzodioxol-5-yl)methanol
• CAS: 883841-91-6
• 化学式: C₂₁H₁₈O₄
• 分子量: 334.372
• InChiKey: ZAHVIOGTDHJOQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-Methoxy-4,5-diphenylmethylenedioxybenzyl alcohol 在 吡啶 、 4-二甲氨基吡啶 、 sodium azide 、 水 、 甲基磺酰氯 、 木榴油 、 三苯基膦 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-(3,4-Dihydroxy-5-methoxybenzylcarbamoyl)-8-hydroxyquinoline-7-carboxylic acid
  参考文献：
  名称：

  Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity

  摘要：

  A novel series of HIV-1 integrase inhibitors was synthesized and tested in both in vitro and ex vivo assays. These inhibitors are featured by the presence of a quinoline subunit and an ancillary aromatic ring linked by functionalized spacers such as amide, hydrazide, urea and 1-hydroxyprop-l-en-3-one moiety. Amide derivatives are the most promising ones and could serve as leads for further developments. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.03.005
• 作为产物：
  描述：

  二氯二苯甲烷 在 lithium aluminium tetrahydride 作用下， 生成 3-Methoxy-4,5-diphenylmethylenedioxybenzyl alcohol
  参考文献：
  名称：

  Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity

  摘要：

  A novel series of HIV-1 integrase inhibitors was synthesized and tested in both in vitro and ex vivo assays. These inhibitors are featured by the presence of a quinoline subunit and an ancillary aromatic ring linked by functionalized spacers such as amide, hydrazide, urea and 1-hydroxyprop-l-en-3-one moiety. Amide derivatives are the most promising ones and could serve as leads for further developments. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.03.005

文献信息

• Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity
  作者：Christophe Bénard、Fatima Zouhiri、Marie Normand-Bayle、Michèle Danet、Didier Desmaële、Hervé Leh、Jean-François Mouscadet、Gladys Mbemba、Claire-Marie Thomas、Sabine Bonnenfant、Marc Le Bret、Jean d'Angelo

  DOI：10.1016/j.bmcl.2004.03.005

  日期：2004.5

  A novel series of HIV-1 integrase inhibitors was synthesized and tested in both in vitro and ex vivo assays. These inhibitors are featured by the presence of a quinoline subunit and an ancillary aromatic ring linked by functionalized spacers such as amide, hydrazide, urea and 1-hydroxyprop-l-en-3-one moiety. Amide derivatives are the most promising ones and could serve as leads for further developments. (C) 2004 Elsevier Ltd. All rights reserved.