(5R,7R)-1-phenyltetradecane-5,7-diol | 1447958-75-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (5R,7R)-1-phenyltetradecane-5,7-diol
• CAS: 1447958-75-9
• 化学式: C₂₀H₃₄O₂
• 分子量: 306.489
• InChiKey: PFCHEZDXUOLKQA-WOJBJXKFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  22
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (5R,7R)-1-phenyltetradecane-5,7-diol 、 2,2-二甲氧基丙烷 在 camphor-10-sulfonic acid 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以76%的产率得到(4R,6R)-4-heptyl-2,2-dimethyl-6-(4-phenylbutyl)-1,3-dioxane
  参考文献：
  名称：

  TiCl4 mediated preparation of (E)-non-conjugated homoallylic alcohols with α-substituted allylsilanes

  摘要：

  The allylation of various aldehydes with alpha-substituted allylsilanes in the presence of TiCl4 has been investigated. It has been shown that these reagents readily allow for good yields and high to excellent diastereoselectivities (up to >20:1) for a series of aldehydes, thereby providing a means of preparing non-conjugated (E)-homoallylic alcohols in a single step. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.06.047
• 作为产物：
  描述：

  3-Phenyl-2-trimethylsilylpropanal 在 正丁基锂 、 氢气 、 palladium(II) hydroxide 作用下， 以 四氢呋喃 、 乙醇 、 正己烷 、 二氯甲烷 为溶剂， 反应 9.75h， 生成 (5R,7R)-1-phenyltetradecane-5,7-diol
  参考文献：
  名称：

  TiCl4 mediated preparation of (E)-non-conjugated homoallylic alcohols with α-substituted allylsilanes

  摘要：

  The allylation of various aldehydes with alpha-substituted allylsilanes in the presence of TiCl4 has been investigated. It has been shown that these reagents readily allow for good yields and high to excellent diastereoselectivities (up to >20:1) for a series of aldehydes, thereby providing a means of preparing non-conjugated (E)-homoallylic alcohols in a single step. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.06.047

文献信息

• TiCl4 mediated preparation of (E)-non-conjugated homoallylic alcohols with α-substituted allylsilanes
  作者：Aymara M.M. Albury、Michael P. Jennings

  DOI：10.1016/j.tetlet.2013.06.047

  日期：2013.8

  The allylation of various aldehydes with alpha-substituted allylsilanes in the presence of TiCl4 has been investigated. It has been shown that these reagents readily allow for good yields and high to excellent diastereoselectivities (up to >20:1) for a series of aldehydes, thereby providing a means of preparing non-conjugated (E)-homoallylic alcohols in a single step. (C) 2013 Elsevier Ltd. All rights reserved.