3-[4-(3-Formyl-phenoxy)-phenyl]-propionic acid | 203510-52-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[4-(3-Formyl-phenoxy)-phenyl]-propionic acid
• CAS: 203510-52-5
• 化学式: C₁₆H₁₄O₄
• 分子量: 270.285
• InChiKey: DRURJEKEZROFTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.31
• 重原子数：
  20.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  63.6
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  3-[4-(3-Formyl-phenoxy)-phenyl]-propionic acid 在 溴棕三甲铵 作用下， 以 水 、 甲苯 为溶剂， 反应 17.17h， 生成 (1R,3R)-3-(2,2-Dibromo-vinyl)-2,2-dimethyl-cyclopropanecarboxylic acid (S)-{3-[4-(2-carboxy-ethyl)-phenoxy]-phenyl}-cyano-methyl ester
  参考文献：
  名称：

  Hapten Synthesis for a Monoclonal Antibody Based ELISA for Deltamethrin

  摘要：

  An enzyme-linked immunosorbent assay (ELISA) was developed for the insecticide deltamethrin. Two haptens were synthesized: the first one was a derivative of the whole molecule with a spacer arm bound to the aromatic ring; the second one was a derivative of deltamethric acid. Twelve monoclonal antibodies were obtained. A competitive ELISA using monoclonal antibody Del 01 yielded the most sensitive assay. The IC50 value for deltamethrin was estimated to be 0.5 mu g mL(-1) with a detection Limit of 0.08 mu g mL(-1). Monoclonal antibody Del 01 seems to be deltamethrin specific since <1% cross-reactivity with other pyrethroid analogues was observed.

  DOI：

  10.1021/jf9703922
• 作为产物：
  描述：

  3-(4-甲氧基苯基)丙酸 在 吡啶 、 盐酸 、 氢氧化钾 、 硫酸 、 氢溴酸 、 sodium methylate 、 copper(l) chloride 作用下， 以 甲醇 、 丙酮 为溶剂， 反应 23.0h， 生成 3-[4-(3-Formyl-phenoxy)-phenyl]-propionic acid
  参考文献：
  名称：

  Hapten Synthesis for a Monoclonal Antibody Based ELISA for Deltamethrin

  摘要：

  An enzyme-linked immunosorbent assay (ELISA) was developed for the insecticide deltamethrin. Two haptens were synthesized: the first one was a derivative of the whole molecule with a spacer arm bound to the aromatic ring; the second one was a derivative of deltamethric acid. Twelve monoclonal antibodies were obtained. A competitive ELISA using monoclonal antibody Del 01 yielded the most sensitive assay. The IC50 value for deltamethrin was estimated to be 0.5 mu g mL(-1) with a detection Limit of 0.08 mu g mL(-1). Monoclonal antibody Del 01 seems to be deltamethrin specific since <1% cross-reactivity with other pyrethroid analogues was observed.

  DOI：

  10.1021/jf9703922