3-hexyloxyiodobenzene | 1092514-59-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-hexyloxyiodobenzene
• 英文别名: 3-hexyloxy-1-iodobenzene；1-(hexyloxy)-3-iodobenzene；1-hexoxy-3-iodobenzene
• CAS: 1092514-59-4
• 化学式: C₁₂H₁₇IO
• 分子量: 304.171
• InChiKey: RCJATOCWSKSNNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-hexyloxyiodobenzene 在 甲醇 、 copper(l) iodide 、 四(三苯基膦)钯 、 水 、 potassium carbonate 、 二乙胺 作用下， 反应 10.0h， 生成 1-ethynyl-3-(hexyloxy)benzene
  参考文献：
  名称：

  Polymerizable UV absorbers for the UV stabilization of polyesters. II. Photodegradation study of UV-stabilized PET copolymers

  摘要：

  DOI：

  10.24820/ark.5550190.p011.617
• 作为产物：
  描述：

  溴己烷 、 3-碘苯酚 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以1.29 g的产率得到3-hexyloxyiodobenzene
  参考文献：
  名称：

  过渡金属配合物的盘状液晶，53†：间烷氧基苯硫基取代的酞菁的合成和介晶

  摘要：

  我们成功合成了一系列新型八（[分子式：见文]-烷氧基苯硫基）酞菁铜（II）配合物，（[分子式：见文]-C[分子式：见文]OPhS）[分子式：见文]PcCu （[公式：见正文] = 2, 4, 6, 8, 10, 12, 14, 16: 1b~1i），通过我们开发的方法来揭示它们的介晶。通过使用偏光光学显微镜、差示扫描量热仪和温度相关的小角 X 射线衍射仪建立了相变行为和中间相结构。有趣的是，很短的链取代衍生物，（[公式：见正文]-C[公式：见正文]OPhS）[公式：见正文]PcCu（1a）和（[公式：见正文]-C[公式：见正文]OPhS)[公式：见正文]PCu (1b)，显示一个六边形有序柱状（Col[公式：见正文]中间相，见正文]-C[公式：见正文]OPhS)[公式：见正文]PcCu (1f) 从 Q 带的吸收边缘分别为 1.79 eV 和 1.70 eV。因此，苯硫基取代的衍生物产生了较窄的带隙。与苯氧基取代的衍生物相比为

  DOI：

  10.1142/s1088424617500389

文献信息

• Lipopeptide Compounds and Their Use
  申请人：Boyce Rustum S.

  公开号：US20110224129A1

  公开（公告）日：2011-09-15

  The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain lipopeptide compounds comprising a cyclic peptide bearing a lipid side chain (for convenience, collectively referred to herein as “LP compounds”), which, inter alia, are antimicrobial, particularly antibacterial. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to provide an antimicrobial function, particularly an antibacterial function, and in the treatment of diseases and conditions that are mediated by microbes, particularly bacteria, that are ameliorated by the antimicrobial function, particularly an antibacterial function, including bacterial diseases, optionally in combination with another agent, for example, another antibacterial agent.

  本发明一般涉及治疗化合物领域，更具体地涉及包括带有脂肪侧链的环肽的某些脂肽化合物（为方便起见，在本文中统称为“LP化合物”），其中，这些化合物具有抗微生物作用，特别是抗菌作用。本发明还涉及包括这些化合物的药物组合物，以及使用这些化合物和组合物，在体外和体内提供抗微生物功能，特别是抗菌功能，以及在治疗由微生物介导的疾病和病症方面的用途，特别是由抗菌功能缓解的细菌疾病，可选地与另一药剂（例如另一抗菌剂）结合使用。
• Improvement of Pharmacological Properties of Irreversible Thyroid Receptor Coactivator Binding Inhibitors
  作者：Jong Yeon Hwang、Leggy A. Arnold、Fangyi Zhu、Aaron Kosinski、Thomas J. Mangano、Vincent Setola、Bryan L. Roth、R. Kiplin Guy

  DOI：10.1021/jm9002704

  日期：2009.7.9

  We have previously reported the discover), and preliminary structure activity relationships of a series of beta-aminoketones that disrupt the binding of coactivators to TR. However, the most active compounds had moderate inhibitory potency and relatively high cytotoxicity, resulting in narrow therapeutic index. Additionally, preliminary evaluation of in vivo toxicology revealed a significant dose related cardiotoxicity. Here we describe the improvement of pharmacological properties of thyroid hormone receptor coactivator binding inhibitors. A comprehensive Survey of the effects of substitutents in key areas of the molecule was carried out based on mechanistic insight from the earlier report. This study revealed that both electron withdrawing and hydrophobic substituents on the aromatic ring led to higher potency. On the other hand, moving from an alkyl to a sulfonyl alkyl side chain led to reduced cytotoxicity, Finally, utilization of airline moieties having low pK(a)'s resulted in lowered ion channel activity without any loss of pharmacological activity.
• LIPOPEPTIDE COMPOUNDS AND THEIR USE
  申请人：Merlion Pharmaceuticals Pte Ltd.

  公开号：EP2350119A1

  公开（公告）日：2011-08-03
• OPTICALLY ANISOTROPIC COMPOUND AND RESIN COMPOSITION COMPRISING THE SAME
  申请人：Cheong Jaeho

  公开号：US20100137484A1

  公开（公告）日：2010-06-03

  Disclosed is a compound having high optical anisotropy and high compatibility with a polymer resin, which is represented by Formula 1 and necessarily has at least one meta substituent. Also, a resin composition including the compound and a polymer resin, and an optical member including the resin composition are disclosed. Since the compound represented by Formula 1 is an anisotropic compound having high compatibility with a polymer resin and high optical anisotropy, in the case of an optical member obtained by using a polymer resin composition including the compound represented by Formula 1, there is no phase separation, and it is possible to achieve a required optical characteristic with only a small amount thereof.
• ADHESIVE COMPOSITION, POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY
  申请人：Jang Ki Seok

  公开号：US20110111140A1

  公开（公告）日：2011-05-12

  The present invention relates to a pressure-sensitive adhesive composition, a polarizer, and a liquid crystal display (LCD). According to the present invention, it is possible to provide a pressure-sensitive adhesive composition, which shows excellent endurance reliability in a high-temperature or high-humidity condition, has superior workability such as a superior re-cutting or re-peeling property, and is capable of effectively suppress light leakage occurring in an LCD, and a polarizer and an LCD which include a cured product of the pressure-sensitive adhesive composition.