N-(6-bromohexyl)acrylamide | 869563-87-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(6-bromohexyl)acrylamide
• 英文别名: 6-bromohexyl-acrylamide；N-(6-bromohexyl)prop-2-enamide
• CAS: 869563-87-1
• 化学式: C₉H₁₆BrNO
• 分子量: 234.136
• InChiKey: PSKHPUWUPHDGIZ-UHFFFAOYSA-N

物化性质

• 沸点：
  356.5±34.0 °C(Predicted)
• 密度：
  1.223±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-(6-bromohexyl)acrylamide 在 lithium tetrachloropalladate(II) hydrate 、 sodium methylate 、 sodium hydroxide 作用下， 以 甲醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 45.5h， 生成 5-(((5-acetamido-3,5-dideoxy-d-glycero-α-d-galacto-2-nonulopyranosonate)-2-S-hexyl)-carbamoyl-vinyl)-2'-deoxyuridine-5'-O-triphosphate triethylamine salt
  参考文献：
  名称：

  Synthesis of neuraminidase-resistant sialoside-modified three-way junction DNA and its binding ability to various influenza viruses

  摘要：

  Natural sialic acid-modified compounds are capable of targeting influenza virus hemagglutinin (HA). However, these compounds have limited inhibitory effect because natural O-glycoside bond in these compounds are prone to be cleaved by neuraminidase (NA) on the surface of viruses. In this study, we synthesized NA resistant sialoside that included unnatural S-glycoside bonds and modified this sialoside on a three-way junction (3WJ) DNA to display complementary distribution to its binding sites on a HA trimer. This S-glycoside-containing sialoside-modified 3WJ DNA showed certain NA-resistance and maintained high binding affinity. Importantly, our observations showed that substituting natural O-glycoside with unnatural S-glycoside did not affect the binding affinity of the sialoside-modified 3WJ DNA for viruses. Thus, this study is an important step forward in the development of NA-resistant sialoside derivatives for more effective detection and inhibition of infection by a broad spectrum of viruses.

  DOI：

  10.1016/j.carres.2019.01.008
• 作为产物：
  描述：

  6-氨基-1-己醇 在 sodium hydroxide 、 甲基磺酰氯 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 7.83h， 生成 N-(6-bromohexyl)acrylamide
  参考文献：
  名称：

  聚合物平台之间的分子转运蛋白：通过结合使用固相和水溶性聚合物载体，可以高效合成化学酶糖肽。

  摘要：

  DOI：

  10.1002/anie.200463065

文献信息

• A highly photosensitive imaging element based on a photosensitive resin
  申请人：AGFA-GEVAERT naamloze vennootschap

  公开号：EP0476187A1

  公开（公告）日：1992-03-25

  According to the present invention a highly photosensitive imaging element is provided, comprising on a support a photosensitive coating comprising a homopolymer or copolymer of a monomer having a styryl type nitrogen-containing heterocyclic ring and wherein the corresponding monomer units have been quaternized from 0 to 100%, characterized in that said photosensitive imaging element was given an overall exposure using an energy dose smaller than the energy dose required for inducing gelation of the photosensitive resin and/or was given a thermal treatment. The present invention further provides a method for making said imaging element. Finally the present invention provides a high photosensitive resin composition based on a homopolymer or copolymer of a monomer of the styryl type nitrogen-containing heterocyclic ring.

  根据本发明，提供了一种高光敏成像元件，该元件在支架上包含一层光敏涂层，该涂层由具有苯乙烯基型含氮杂环的单体的均聚物或共聚物组成，其中相应的单体单元已被季铵化0至100%，其特征在于，所述光敏成像元件经过整体曝光，使用的能量剂量小于诱导光敏树脂凝胶化所需的能量剂量，并且/或者经过热处理。本发明进一步提供了制造所述成像元件的方法。最后，本发明提供了一种基于苯乙烯类含氮杂环单体的均聚物或共聚物的高光敏树脂组合物。
• High-Throughput Protein Glycomics: Combined Use of Chemoselective Glycoblotting and MALDI-TOF/TOF Mass Spectrometry
  作者：Shin-Ichiro Nishimura、Kenichi Niikura、Masaki Kurogochi、Takahiko Matsushita、Masataka Fumoto、Hiroshi Hinou、Ryousuke Kamitani、Hiroaki Nakagawa、Kisaburo Deguchi、Nobuaki Miura、Kenji Monde、Hirosato Kondo

  DOI：10.1002/anie.200461685

  日期：2005.1
• Functional capsule membranes. 27. A new type of phase-transfer catalysts (PTC). Reaction of substrates in the inner organic phase with the outer aqueous anions catalyzed by PTC grafted on the capsule membrane
  作者：Yoshio Okahata、Katsuhiko Ariga

  DOI：10.1021/jo00376a003

  日期：1986.12
• AMPHIPHILIC POLYMER AND PROCESSES OF FORMING THE SAME
  申请人：Janczewski Dominik

  公开号：US20100298504A1

  公开（公告）日：2010-11-25

  Disclosed are an amphiphilic polymer, its synthesis and uses thereof. The polymer has a hydrocarbon backbone with —COOH side groups. It further has first aliphatic moieties with a main chain of about 3 to about 20 carbon atoms and 0 to about 3 heteroatoms, and second aliphatic moieties that have a main chain of about 3 to about 80 carbon atoms and about 2 to about 40 heteroatoms. The second aliphatic moieties have a copolymerisable group. In the synthesis a maleic anhydride polymer of formula (I) where n is an integer from about 10 to about 10000 and R1 is H or methyl, is reacted with a monofunctional compound with an alkyl chain of about 3 to about 20 carbon atoms and 0 to about 2 heteroatoms, and with an at least bifunctional compound with an alkyl chain of about 3 to about 80 carbon atoms and 0 to about 40 heteroatoms. The functional group of the monofunctional compound and one functional group of the at least bifunctional compound can form a linkage with an anhydride. Another functional group of the at least bifunctional compound, which is not allowed to react with the maleic anhydride polymer, is copolymerisable.
• [EN] AMPHIPHILIC POLYMER AND PROCESSES OF FORMING THE SAME<br/>[FR] POLYMÈRE AMPHIPHILE ET SES PROCÉDÉS DE FABRICATION
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2009038544A1

  公开（公告）日：2009-03-26

  Disclosed are an amphiphilic polymer, its synthesis and uses thereof. The polymer has a hydrocarbon backbone with -COOH side groups. It further has first aliphatic moieties with a main chain of about 3 to about 20 carbon atoms and 0 to about 3 heteroatoms, and second aliphatic moieties that have a main chain of about 3 to about 80 carbon atoms and about 2 to about 40 heteroatoms. The second aliphatic moieties have a copolymerisable group. In the synthesis a maleic anhydride polymer of formula (I) where n is an integer from about 10 to about 10000 and R1 is H or methyl, is reacted with a monofunctional compound with an alkyl chain of about 3 to about 20 carbon atoms and 0 to about 2 heteroatoms, and with an at least bifunctional compound with an alkyl chain of about 3 to about 80 carbon atoms and 0 to about 40 heteroatoms. The functional group of the monofunctional compound and one functional group of the at least bifunctional compound can form a linkage with an anhydride. Another functional group of the at least bifunctional compound, which is not allowed to react with the maleic anhydride polymer, is copolymerisable.